Bekaplermin
| Klinički podaci | |
|---|---|
| Robne marke | Regranex, Regranex (OMJ Pharmaceuticals) |
| AHFS/Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 165101-51-9 |
| ATC kod | D03AX06 , A01AD08 |
| DrugBank | DB00102 |
| ChEMBL[1] | CHEMBL1201556 
|
| Hemijski podaci | |
| Formula | ? |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | topikalno |
Bekaplermin (Regranex) cikatrizant je koji je dostupa u obliku topikalnog gela. On se koristi za tretiranje dijabetičkih čireva stopala.[2] Bekaplermin se proizvodi primenom rekombinantne DNK tehnologije na kvascu Saccharomyces cerevisiae. Bekaplermin je homodimer čiji polipeptidni lanci su vezani disulfidnim vezama[3][4]
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Nagai MK, Embil JM (February 2002). „Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers”. Expert Opin Biol Ther 2 (2): 211–8. DOI:10.1517/14712598.2.2.211. PMID 11849120.
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
