CCL22

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Hemokin (C-C motiv) ligand 22
Identifikatori
SimboliCCL22; MDC; A-152E5.1; ABCD-1; DC/B-CK; MGC34554; SCYA22; STCP-1
Vanjski IDOMIM: 602957 MGI: 1306779 HomoloGene: 7529 GeneCards: CCL22 Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez636720299
EnsemblENSG00000102962ENSMUSG00000031779
UniProtO00626Q546S6
RefSeq (mRNA)NM_002990NM_009137
RefSeq (protein)NP_002981NP_033163
Lokacija (UCSC)Chr 16:
55.95 - 55.96 Mb		Chr 8:
97.63 - 97.64 Mb
PubMed pretraga[1][2]

CCL22, hemokin (C-C motiv) ligand 22, je protein koji je kod ljudi kodiran CCL22 genom.[1][2][3][4]

Ovaj protein izlučuju dendritske ćelije i makrofage. On dejstvuje na svoje ciljne ćelije target putem interakcija sa hemokinski receptorima na ćelijskoj površini kao što je CCR4.[5] CCL22 gen je lociran na ljudskom hromozomu 16 u klasteru sa drugim hemokinima: CX3CL1 i CCL17.[6][7]

Reference

[uredi | uredi kod]
  1. ↑ Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (Jun 1997). „Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells”. J Exp Med 185 (9): 1595–604. PMC 2196293. PMID 9151897. 
  2. ↑ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (Oct 1998). „Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13”. Cytogenet Cell Genet 81 (1): 10–1. PMID 9691168. 
  3. ↑ „Entrez Gene: CCL22 chemokine (C-C motif) ligand 22”. 
  4. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  5. ↑ Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S (2001). „Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo”. Eur. J. Immunol. 31 (3): 812–22. DOI:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L. PMID 11241286. 
  6. ↑ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). „Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q”. Genomics 60 (3): 295–308. DOI:10.1006/geno.1999.5927. PMID 10493829. 
  7. ↑ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). „Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13”. Cytogenet. Cell Genet. 81 (1): 10–1. DOI:10.1159/000015000. PMID 9691168. 

Literatura

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  • Chang M, McNinch J, Elias C, et al. (1997). „Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes.”. J. Biol. Chem. 272 (40): 25229–37. DOI:10.1074/jbc.272.40.25229. PMID 9312138. 
  • Pal R, Garzino-Demo A, Markham PD, et al. (1997). „Inhibition of HIV-1 infection by the beta-chemokine MDC.”. Science 278 (5338): 695–8. DOI:10.1126/science.278.5338.695. PMID 9381181. 
  • Imai T, Chantry D, Raport CJ, et al. (1998). „Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.”. J. Biol. Chem. 273 (3): 1764–8. DOI:10.1074/jbc.273.3.1764. PMID 9430724. 
  • Struyf S, Proost P, Sozzani S, et al. (1998). „Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor.”. J. Immunol. 161 (6): 2672–5. PMID 9743322. 
  • Meucci O, Fatatis A, Simen AA, et al. (1998). „Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.”. Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14500–5. DOI:10.1073/pnas.95.24.14500. PMC 24402. PMID 9826729. 
  • Proost P, Struyf S, Schols D, et al. (1999). „Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.”. J. Biol. Chem. 274 (7): 3988–93. DOI:10.1074/jbc.274.7.3988. PMID 9933589. 
  • Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). „Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.”. Genomics 60 (3): 295–308. DOI:10.1006/geno.1999.5927. PMID 10493829. 
  • Annunziato F, Romagnani P, Cosmi L, et al. (2000). „Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection.”. J. Immunol. 165 (1): 238–46. PMID 10861057. 
  • Vulcano M, Albanesi C, Stoppacciaro A, et al. (2001). „Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.”. Eur. J. Immunol. 31 (3): 812–22. DOI:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L. PMID 11241286. 
  • Berin MC, Dwinell MB, Eckmann L, Kagnoff MF (2001). „Production of MDC/CCL22 by human intestinal epithelial cells.”. Am. J. Physiol. Gastrointest. Liver Physiol. 280 (6): G1217–26. PMID 11352815. 
  • Lambeir AM, Proost P, Durinx C, et al. (2001). „Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.”. J. Biol. Chem. 276 (32): 29839–45. DOI:10.1074/jbc.M103106200. PMID 11390394. 
  • Wakahara S, Fujii Y, Nakao T, et al. (2002). „Gene expression profiles for Fc epsilon RI, cytokines and chemokines upon Fc epsilon RI activation in human cultured mast cells derived from peripheral blood.”. Cytokine 16 (4): 143–52. DOI:10.1006/cyto.2001.0958. PMID 11792124. 
  • Ghia P, Strola G, Granziero L, et al. (2002). „Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22.”. Eur. J. Immunol. 32 (5): 1403–13. DOI:10.1002/1521-4141(200205)32:5<1403::AID-IMMU1403>3.0.CO;2-Y. PMID 11981828. 
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