COPG

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Koatomerni proteinski kompleks, podjedinica gama
PDB prikaz baziran na 1pzd.
Dostupne strukture
1pzd, 1r4x
Identifikatori
Simboli	COPG; COPG1; FLJ21068
Vanjski ID	MGI: 1858696 HomoloGene: 56745 GeneCards: COPG Gene
Ontologija gena Molekularna funkcija • aktivnost strukturnog molekula • proteinsko vezivanje Celularna komponenta • Goldžijeva membrana • citoplazmam • Goldžijev aparat • Goldžem potpomognuta vezikula • citosol • membrana • membranski pokrivač • COPI vezikularni pokrivač • citoplazmatična vezikula Biološki proces • intracelularni proteinski transport • retrogradni vezikulom posredovani transport, Goldži do ER • celularna membranska organizacija • vezikulom posredovani transport • COPI pokrivač Goldžijevog aparata
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	22820	54161
Ensembl	ENSG00000181789	ENSMUSG00000030058
UniProt	Q9Y678	n/a
RefSeq (mRNA)	NM_016128	NM_017477
RefSeq (protein)	NP_057212	NP_059505
Lokacija (UCSC)	Chr 3: 128.97 - 129 Mb	Chr 6: 87.84 - 87.86 Mb
PubMed pretraga	[1]	[2]

Koatomerna podjedinica gama je protein koji je kod ljudi kodiran COPG genom.^[1][2]

Interakcije

Za COPG je pokazano da formira interakcije sa dopaminskim receptorom D1,^[3] COPZ1^[4][5] i COPB1.^[1][6]

Reference

1. Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (February 2001). „Identification and characterization of novel isoforms of COP I subunits”. J Biochem 128 (5): 793–801. PMID 11056392. 
2. „Entrez Gene: COPG coatomer protein complex, subunit gamma”. 
3. Bermak, Jason C; Li Ming, Bullock Clayton, Weingarten Paul, Zhou Qun-Yong (February 2002). „Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus”. Eur. J. Cell Biol. (Germany) 81 (2): 77–85. DOI:10.1078/0171-9335-00222. ISSN 0171-9335. PMID 11893085. 
5. Faulstich, D; Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland F T, Tschochner H (October 1996). „Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex”. J. Cell Biol. (UNITED STATES) 135 (1): 53–61. DOI:10.1083/jcb.135.1.53. ISSN 0021-9525. PMC 2121028. PMID 8858162. 
6. Lowe, M; Kreis T E (November 1996). „In vivo assembly of coatomer, the COP-I coat precursor”. J. Biol. Chem. (UNITED STATES) 271 (48): 30725–30. DOI:10.1074/jbc.271.48.30725. ISSN 0021-9258. PMID 8940050. 

Literatura

• Lowe M, Kreis TE (1997). „In vivo assembly of coatomer, the COP-I coat precursor.”. J. Biol. Chem. 271 (48): 30725–30. DOI:10.1074/jbc.271.48.30725. PMID 8940050. 
• Pavel J, Harter C, Wieland FT (1998). „Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.”. Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. DOI:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852. 
• Fischer KD, Helms JB, Zhao L, Wieland FT (2000). „Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles.”. Methods 20 (4): 455–64. DOI:10.1006/meth.2000.0958. PMID 10720466. 
• Eugster A, Frigerio G, Dale M, Duden R (2000). „COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.”. EMBO J. 19 (15): 3905–17. DOI:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873. 
• Hu RM, Han ZG, Song HD, et al. (2000). „Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.”. Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. DOI:10.1073/pnas.160270997. PMC 16901. PMID 10931946. 
• Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). „RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.”. Mol. Biol. Cell 11 (9): 3155–68. PMC 14982. PMID 10982407. 
• Hahn Y, Lee YJ, Yun JH, et al. (2000). „Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution.”. FEBS Lett. 482 (1–2): 31–6. DOI:10.1016/S0014-5793(00)02033-0. PMID 11018518. 
• Paulsson KM, Kleijmeer MJ, Griffith J, et al. (2002). „Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum”. J. Biol. Chem. 277 (21): 18266–71. DOI:10.1074/jbc.M201388200. PMID 11884415. 
• Bermak JC, Li M, Bullock C, et al. (2002). „Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus”. Eur. J. Cell Biol. 81 (2): 77–85. DOI:10.1078/0171-9335-00222. PMID 11893085. 
• Kanzaki M, Watson RT, Hou JC, et al. (2003). „Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes”. Mol. Biol. Cell 13 (7): 2334–46. DOI:10.1091/mbc.01-10-0490. PMC 117317. PMID 12134073. 
• Xu Y, Martin S, James DE, Hong W (2003). „GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus”. Mol. Biol. Cell 13 (10): 3493–507. DOI:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Rohde HM, Cheong FY, Konrad G, et al. (2004). „The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex”. J. Biol. Chem. 278 (52): 52689–99. DOI:10.1074/jbc.M307983200. PMID 14527956. 
• Watson PJ, Frigerio G, Collins BM, et al. (2004). „Gamma-COP appendage domain - structure and function”. Traffic 5 (2): 79–88. DOI:10.1111/j.1600-0854.2004.00158.x. PMID 14690497. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Ewing RM, Chu P, Elisma F, et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931.