COPG2

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Koatomerni proteinski kompleks, podjedinica gama 2
Identifikatori
Simboli	COPG2; 2-COP; DKFZp761N09121; FLJ11781
Vanjski ID	OMIM: 604355 HomoloGene: 56292 GeneCards: COPG2 Gene
Ontologija gena Molekularna funkcija • aktivnost strukturnog molekula • proteinsko vezivanje Celularna komponenta • Goldžijeva membrana • citoplazma • Goldžijev aparat • membrana • membranski pokrivač • pokrivač COPI vezikule • citoplazmatična vetikula Biološki proces • intracelularni proteinski transport • retrogradni vezikulom posredovani transport, Goldži do ER • intra-Goldžijev vezikulom posredovani transport • vezikulom posredovani transport
Ortolozi
Vrsta	Čovek	Miš
Entrez	26958	54160
Ensembl	n/a	ENSMUSG00000025607
UniProt	n/a	n/a
RefSeq (mRNA)	NM_012133	NM_017478.2
RefSeq (protein)	NP_036265	NP_059506.1
Lokacija (UCSC)	n/a	Chr 6: 30.7 - 30.85 Mb
PubMed pretraga	[1]	[2]

Koatomerna podjedinica gama-2 je protein koji je kod ljudi kodiran COPG2 genom.^[1][2][3]

Interakcije

Za COPG2 je pokazano da formira interakcije sa dopaminskim receptorom D1^[4] i COPB1.^[5][6]

Izvori

1. Blagitko N, Schulz U, Schinzel AA, Ropers HH, Kalscheuer VM (Jan 2000). „gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome”. Hum Mol Genet 8 (13): 2387–96. DOI:10.1093/hmg/8.13.2387. PMID 10556286. 
2. Yamasaki K, Hayashida S, Miura K, Masuzaki H, Ishimaru T, Niikawa N, Kishino T (Nov 2000). „The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting”. Genomics 68 (3): 330–5. DOI:10.1006/geno.2000.6265. PMID 10995575. 
3. „Entrez Gene: COPG2 coatomer protein complex, subunit gamma 2”. 
4. Bermak, Jason C; Li Ming, Bullock Clayton, Weingarten Paul, Zhou Qun-Yong (February 2002). „Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus”. Eur. J. Cell Biol. (Germany) 81 (2): 77–85. DOI:10.1078/0171-9335-00222. ISSN 0171-9335. PMID 11893085. 
5. Takatsu, H; Futatsumori M, Yoshino K, Yoshida Y, Shin H W, Nakayama K (June 2001). „Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system”. Biochem. Biophys. Res. Commun. (United States) 284 (4): 1083–9. DOI:10.1006/bbrc.2001.5081. ISSN 0006-291X. PMID 11409905. 
6. Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (2000). „Identification and characterization of novel isoforms of COP I subunits.”. J Biochem 128 (5): 793–801. PMID 11056392. 

Literatura

• Pelham HR, Rothman JE (2000). „The debate about transport in the Golgi--two sides of the same coin?”. Cell 102 (6): 713–9. DOI:10.1016/S0092-8674(00)00060-X. PMID 11030615. 
• Waters MG, Serafini T, Rothman JE (1991). „'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles.”. Nature 349 (6306): 248–51. DOI:10.1038/349248a0. PMID 1898986. 
• Lowe M, Kreis TE (1997). „In vivo assembly of coatomer, the COP-I coat precursor.”. J. Biol. Chem. 271 (48): 30725–30. DOI:10.1074/jbc.271.48.30725. PMID 8940050. 
• Harter C, Wieland FT (1998). „A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer.”. Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11649–54. DOI:10.1073/pnas.95.20.11649. PMC 21695. PMID 9751720. 
• Zhao L, Helms JB, Brunner J, Wieland FT (1999). „GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23.”. J. Biol. Chem. 274 (20): 14198–203. DOI:10.1074/jbc.274.20.14198. PMID 10318838. 
• Eugster A, Frigerio G, Dale M, Duden R (2000). „COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.”. EMBO J. 19 (15): 3905–17. DOI:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873. 
• Futatsumori M, Kasai K, Takatsu H, et al. (2001). „Identification and characterization of novel isoforms of COP I subunits.”. J. Biochem. 128 (5): 793–801. PMID 11056392. 
• Takatsu H, Futatsumori M, Yoshino K, et al. (2001). „Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.”. Biochem. Biophys. Res. Commun. 284 (4): 1083–9. DOI:10.1006/bbrc.2001.5081. PMID 11409905. 
• Paulsson KM, Kleijmeer MJ, Griffith J, et al. (2002). „Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum.”. J. Biol. Chem. 277 (21): 18266–71. DOI:10.1074/jbc.M201388200. PMID 11884415. 
• Bermak JC, Li M, Bullock C, et al. (2002). „Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.”. Eur. J. Cell Biol. 81 (2): 77–85. DOI:10.1078/0171-9335-00222. PMID 11893085. 
• Bonora E, Bacchelli E, Levy ER, et al. (2002). „Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.”. Mol. Psychiatry 7 (3): 289–301. DOI:10.1038/sj.mp.4001004. PMID 11920156. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205. 
• Scanlan MJ, Gout I, Gordon CM, et al. (2003). „Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.”. Cancer Immun. 1: 4. PMID 12747765. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 
• Ewing RM, Chu P, Elisma F, et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry.”. Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931.