GNAI3

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Guanin nukleotid-vezujući protein (G protein), alfa inhibirajući polipeptid 3
PDB prikaz baziran na 1agr.
Dostupne strukture
1agr, 1as0, 1as2, 1as3, 1bh2, 1bof, 1cip, 1gdd, 1gfi, 1gg2, 1gia, 1gil, 1git, 1gp2, 1kjy, 1svk, 1svs, 1y3a, 2g83, 2gtp, 2hlb, 2ihb, 2ik8, 2ode
Identifikatori
Simboli	GNAI3; 87U6; FLJ26559
Vanjski ID	OMIM: 139370 MGI: 95773 HomoloGene: 55975 GeneCards: GNAI3 Gene
Ontologija gena Molekularna funkcija • vezivanje nukleotida • aktivnost GTPaze • aktivnost prenosnika signala • vezivanje proteina • GTP vezivanje Celularna komponenta • citoplazma • Goldžjev aparat Biološki proces • transport • prenos signala • signalni put G-protein spregnutog receptora • negativna regulacija aktivnosti adenilat ciklaze
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2773	14679
Ensembl	ENSG00000065135	ENSMUSG00000000001
UniProt	P08754	Q3TJH1
RefSeq (mRNA)	NM_006496	NM_010306
RefSeq (protein)	NP_006487	NP_034436
Lokacija (UCSC)	Chr 1: 109.89 - 109.94 Mb	Chr 3: 108.24 - 108.27 Mb
PubMed pretraga	[1]	[2]

GNAI3, Guanin nukleotid-vezujući protein G(i), alfa-3 podjedinica, je protein koji je kod ljudi kodiran GNAI3 genom.Didsbury JR, Snyderman R (Aug 1987). „Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families”. FEBS Lett 219 (1): 259–63. DOI:10.1016/0014-5793(87)81228-0. PMID 3109953. </ref>^[1]

Interakcije

Za GNAI3 je bilo pokazano da ostvaruje interakcije sa RGS14,^[2] RIC8A,^[3] RGS18,^[4][5] S1PR1,^[6] RGS12,^[2] RGS16,^[7][8] RGS19,^[9][10][11] RGS10^[12] i RGS5.^[7][13]

Reference

1. „Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3”. 
2. Kimple, R J; De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P (August 2001). „RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. J. Biol. Chem. (United States) 276 (31): 29275–81. DOI:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333. 
3. Tall, Gregory G; Krumins Andrejs M, Gilman Alfred G (March 2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. (United States) 278 (10): 8356–62. DOI:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430. 
4. Yowe, D; Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie T M, Gutierrez-Ramos C, Hodge M R (October 2001). „RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes”. Biochem. J. (England) 359 (Pt 1): 109–18. DOI:10.1042/0264-6021:3590109. ISSN 0264-6021. PMC 1222126. PMID 11563974. 
5. Gagnon, Alison W; Murray David L, Leadley Robert J (July 2002). „Cloning and characterization of a novel regulator of G protein signalling in human platelets”. Cell. Signal. (England) 14 (7): 595–606. DOI:10.1016/S0898-6568(02)00012-8. ISSN 0898-6568. PMID 11955952. 
6. Lee, M J; Evans M, Hla T (May 1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. J. Biol. Chem. (UNITED STATES) 271 (19): 11272–9. DOI:10.1074/jbc.271.19.11272. ISSN 0021-9258. PMID 8626678. 
7. Chen, C; Zheng B, Han J, Lin S C (March 1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. DOI:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700. 
8. Beadling, C; Druey K M, Richter G, Kehrl J H, Smith K A (March 1999). „Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes”. J. Immunol. (UNITED STATES) 162 (5): 2677–82. ISSN 0022-1767. PMID 10072511. 
9. De Vries, L; Elenko E, Hubler L, Jones T L, Farquhar M G (December 1996). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15203–8. DOI:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. 
10. Woulfe, D S; Stadel J M (June 1999). „Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP”. J. Biol. Chem. (UNITED STATES) 274 (25): 17718–24. DOI:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213. 
11. De Vries, L; Mousli M, Wurmser A, Farquhar M G (December 1995). „GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (25): 11916–20. DOI:10.1073/pnas.92.25.11916. ISSN 0027-8424. PMC 40514. PMID 8524874. 
12. Hunt, T W; Fields T A, Casey P J, Peralta E G (September 1996). „RGS10 is a selective activator of G alpha i GTPase activity”. Nature (ENGLAND) 383 (6596): 175–7. DOI:10.1038/383175a0. ISSN 0028-0836. PMID 8774883. 
13. Zhou, J; Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (February 2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. (England) 68 (13): 1457–69. DOI:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162. 

Literatura

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• Codina J, Olate J, Abramowitz J, et al. (1988). „Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels.”. J. Biol. Chem. 263 (14): 6746–50. PMID 2452165. 
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• De Vries L, Mousli M, Wurmser A, Farquhar MG (1996). „GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.”. Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11916–20. DOI:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874. 
• Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. DOI:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586. 
• Lee MJ, Evans M, Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.”. J. Biol. Chem. 271 (19): 11272–9. DOI:10.1074/jbc.271.19.11272. PMID 8626678. 
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• Hunt TW, Fields TA, Casey PJ, Peralta EG (1996). „RGS10 is a selective activator of G alpha i GTPase activity.”. Nature 383 (6596): 175–7. DOI:10.1038/383175a0. PMID 8774883. 

Povezano

• Gi alfa podjedinica