Imigluceraza
| Klinički podaci | |
|---|---|
| AHFS/Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 143003-46-7 |
| ATC kod | A16AB02 |
| DrugBank | DB00053 |
| ChEMBL[1] | CHEMBL1201632 
|
| Hemijski podaci | |
| Formula | C2532H3854N672O711S16 |
| Mol. masa | 55597.4 |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 3,6-10,4 min |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | Intravenozno |
Imigluceraza je lek koji se koristi za tretiranje Gaučeve bolest.[2][3] Imigluceraza je ljudska beta-glukocerebrozidaza ili beta-D-glukozil-N-acilsfingozin glukohidrolaza (EC 3.2.1.45). Ona je 497 aminokiselina dug protein sa N-vezanim ugljenim hidratima. Algluceraza se priprema modifikovanjem oligosaharidnih lanaca ljudske beta-glukocerebrozidaze. Time se menjaju šećerni ostaci na neredukujućim krajevima oligosaharidnih lanaca glikoproteina tako da postaju predominantno završeni manoznim ostacima.[4][5][6]
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Weinreb NJ (August 2008). „Imiglucerase and its use for the treatment of Gaucher's disease”. Expert Opin Pharmacother 9 (11): 1987–2000. DOI:10.1517/14656566.9.11.1987. PMID 18627336.
- ↑ Starzyk K, Richards S, Yee J, Smith SE, Kingma W (February 2007). „The long-term international safety experience of imiglucerase therapy for Gaucher disease”. Mol. Genet. Metab. 90 (2): 157–63. DOI:10.1016/j.ymgme.2006.09.003. PMID 17079176.
- ↑ Pastores GM, Hughes DA: Gaucher Disease PMID 20301446
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
