Karboksipeptidaza D

Karboksipeptidaza D
Identifikatori
EC broj	3.4.16.6
CAS broj	153967-26-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Karboksipeptidaza D (EC 3.4.16.6, serinska karboksipeptidaza II žitarica, Saccharomyces cerevisiae KEX1 genski produkt, karboksipeptidaza Kex1, gen KEX1 serinska karboksipeptidaza, KEX1 karboksipeptidaza, KEX1 proteinaza, KEX1DELTAp, CPDW-II, serinska karboksipeptidaza, Phaseolus proteinaza) je enzim.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferenciono odvajanje C-terminalnih argininskih ili lizinskih ostataka

Ova karboksipeptidaza je optimalno aktivan na pH 4.5-6.0. Inhibira je diizopropil fluorofosfat, i senzitivna je na tiol-blokirajuće reagense.

Reference

1. Breddam, K. (1986). „Serine carboxypeptidases. A review”. Carlsberg Res. Commun. 51: 83-128. 
2. Breddam, K., Sørensen, S.B. and Svendsen, I. (1987). „Primary structure and enzymatic properties of carboxypeptidase II from wheat bran”. Carlsberg Res. Commun. 52: 297-311. 
3. Dmochowska, A., Dignard, D., Henning, D., Thomas, D.Y. and Bussey, H. (1987). „Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and α-factor precursor processing”. Cell 50: 573-584. PMID 3301004. 
4. Liao, D.-I., Breddam, K., Sweet, R.M., Bullock, T. and Remington, S.J. (1992). „Refined atomic model of wheat serine carboxypeptidase II at 2.2-Å resolution”. Biochemistry 31: 9796-9812. PMID 1390755. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Carboxypeptidase+D