Kaspaza-10

Kaspaza-10
Identifikatori
EC broj	3.4.22.63
CAS broj	189088-85-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Kaspaza-10 (EC 3.4.22.63, FLICE2, Mch4, CASP-10, ICE-slična apoptotička proteaza 4, apoptotička proteaza Mch-4) je enzim.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence Leu-Gln-Thr-Asp-Gly

Kaspaza-10 je inicijatorna kaspaza, koji što su i kaspaza-2 (EC 3.4.22.55), kaspaza-8 (EC 3.4.22.61) i kaspaza-9 (EC 3.4.22.62).

Reference

1. Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820. 
2. Fischer, U., Stroh, C. and Schulze-Osthoff, K. (2006). „Unique and overlapping substrate specificities of caspase-8 and caspase-10”. Oncogene 25: 152-159. PMID 16186808. 
3. Shikama, Y., Yamada, M. and Miyashita, T. (2003). „Caspase-8 and caspase-10 activate NF-κB through RIP, NIK and IKKα kinases”. Eur. J. Immunol. 33: 1998-2006. PMID 12884866. 
4. Boatright, K.M., Deis, C., Denault, J.B., Sutherlin, D.P. and Salvesen, G.S. (2004). „Activation of caspases-8 and -10 by FLIP_L”. Biochem. J. 382: 651-657. PMID 15209560. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH Caspase-10