Katepsin-D

Katepsin-D
Identifikatori
EC broj	3.4.23.5
CAS broj	9025-26-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Katepsin-D (EC 3.4.23.5, Cathepsin D) je enzim.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Specifičnost je slična, mada uža, od pepsina A. Ne dolazi do razlaganja Gln⁴-His veze u B lancu insulina

Ovaj enzim se javlja intraćelijski u lizozomima.

Reference

1. Barrett, A.J. (1977). „Cathepsin D and other carboxyl proteinases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 209-248. 
2. Takahashi, T. and Tang, J. (1981). „Cathepsin D from porcine and bovine spleen”. Methods Enzymol. 80: 565-581. PMID 7341918. 
3. Faust, P.L., Kornfeld, S. and Chirgwin, J.M. (1985). „Cloning and sequence analysis of cDNA for human cathepsin D”. Proc. Natl. Acad. Sci. USA 82: 4910-4914. PMID 3927292. 
4. Conner, G.E. (1989). „Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme”. Biochem. J. 263: 601-604. PMID 2512908. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

• Barrett, A.J. (1977). „Cathepsin D and other carboxyl proteinases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 209-248. 

Spoljašnje veze

• MeSH Cathepsin+D