Matriptaza

Matriptaza
Identifikatori
EC broj	3.4.21.109
CAS broj	241475-96-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Matriptaza (EC 3.4.21.109, serinska proteaza 14, membranski-tip serinske proteaza 1, MT-SP1, prostamin, serinska proteaza TADG-15, diferencijalno izraženi protein gena 15 asociran sa tumorom, ST14, proteaza raka dojke 80 kDa, epitin, serinska endopeptidaza SNC19) je enzim.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

Presecanje raznih sintetičkih supstrata sa Arg ili Lys u P1 poziciji i sa preferencijom za aminokiseline sa malim bočnim lancima (Ala i Gly) u P2 poziciji

Ova tripsin-slična integralno-membranska serinska peptidaza učestvuje u razvoju i metastazi raka dojke.

Reference

1. Lee, S.L., Dickson, R.B. and Lin, C.Y. (2000). „Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease”. J. Biol. Chem. 275: 36720-36725. PMID 10962009. 
2. Lin, C.Y., Anders, J., Johnson, M., Sang, Q.A. and Dickson, R.B. (1999). „Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity”. J. Biol. Chem. 274: 18231-18236. PMID 10373424. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH Matriptase