Megestrol
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| (IUPAC) ime
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| (1S,2R,10R,11S,14R,15S)-14-acetil-14-hidroksi-2,15-dimetiltetraciklo[8.7.0.0^{2,7}.0^{11,15}]heptadeka-6,8-dien-5-on
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| Klinički podaci
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| Robne marke
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Magestin, Megace, Megeron, Niagestin
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| AHFS/Drugs.com
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Monografija
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| Identifikatori
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| CAS broj
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3562-63-8
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| ATC kod
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G03AC05 , G03DB04
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| DrugBank
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DB00351
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| KEGG[1]
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C07120  Y
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| ChEMBL[2]
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CHEMBL6722 Y
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| Hemijski podaci
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| Formula
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C21H28O3
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| Mol. masa
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328.4452
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C21H28O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4-5,12,16-18,24H,6-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
Key: JBVNBBXAMBZTMQ-CEGNMAFCSA-N Y |
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| Fizički podaci
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| Tačka topljenja
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218.0-220.0 °C (-146 °F)
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| Farmakokinetički podaci
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| Poluvreme eliminacije
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34 sata
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| Izlučivanje
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Urinom
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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|
| Način primene
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Oralno; Oralno;
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Megestrol (17-hidroksi-6-metilpregna-3,6-dien-3,20-dion) je progestinski hormon koji se koristi u obliku acetatnog estra. On je potentniji od progesterona kao progestageni i ovulacioni inhibitor. Takođe je korišćen u palijativno lečenje raka dojke.[3][4][5]
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Berenstein EG, Ortiz Z: Megestrol acetate for the treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004310. PMID 15846706
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.
