Mikotiol-zavisna formaldehid dehidrogenaza
| Mikotiol-zavisna formaldehid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.66 | ||||||||
| CAS broj | 192140-85-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Mikotiol-zavisna formaldehid dehidrogenaza (EC 1.2.1.66, NAD/factor-zavisna formaldehidna dehidrogenaza) je enzim sa sistematskim imenom formaldehid:NAD+ oksidoreduktaza (mikotiol-formilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- formaldehid + mikotiol + NAD+ S-formilmikotiol + NADH + 2 H+
Formirani S-formilmikotiol se hidrolizuje do mikotiola i formata.
- ↑ Misset-Smits, M., Van Ophem, P.W., Sakuda, S. and Duine, J.A. (1997). „Mycothiol, 1-O-(2′-[N-acetyl-L-cysteinylamido-2′-deoxy-α-D-glucopyranosyl)-D-myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase”]. FEBS Lett. 409: 221-222. PMID 9202149.
- ↑ Norin, A., Van Ophem, P.W., Piersma, S.R., Person, B., Duine, J.A. and Jornvall, H. (1997). „Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaryotic alcohol dehydrogenase's - primary structure, conformational modelling and functional correlations”. Eur. J. Biochem. 248: 282-289. PMID 9346279.
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