N-Acetilaspartinska kiselina

N-Acetilaspartinska kiselina
	2-Acetamidobutandioinska kiselina
Identifikacija
CAS registarski broj	2545-40-6 , 997-55-7 S
PubChem	97508, ; 774916 R, ; 65065 S
ChemSpider	88007 , 677387 R
EINECS broj	219-827-5
KEGG	C01042
MeSH	N-acetylaspartate
ChEBI	21547
ChEMBL	CHEMBL1162493
RTECS registarski broj toksičnosti	CI9098600
Bajlštajn	1726198 S
3DMet	B00227
Jmol-3D slike	Slika 1; Slika 2
SMILES
	Cc(:[o]):[nH]C(Cc(:[o]):[oH])c(:[o]):[oH] CC(=O)NC(CC(O)=O)C(O)=O
InChI
	InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12) ; Kod: OTCCIMWXFLJLIA-UHFFFAOYSA-N
Svojstva
Molekulska formula	C6H9NO5
Molarna masa	175.14 g mol−1
Agregatno stanje	Bezbojni, transparentni kristali
Tačka ključanja	141-144 °C, 414-417 K, 286-291 °F
log P	−2.209
pKa	3.142
Baznost (pKb)	10.855
Opasnost
S-oznake	S22, S24/25
Srodna jedinjenja
Srodna alkanoinske kiseline	3-Ureidopropionska kiselina; beta-Ureidoizobutirinska kiselina; Karbamoil aspartinska kiselina; Aceglutamid; N-Acetilglutaminska kiselina; Citrulin;
Srodna jedinjenja	Bromizoval; Karbromal;
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

N-Acetilaspartic acid (N-acetilaspartat, NAA) je derivat aspartinske kiseline sa formulom C₆H₉NO₅ i molekulskom težinom 175,139.

NAA je drugi po zastupljenosti neurotransmiter u mozgu, posle glutamatne aminokiseline. On je prisutan u mozgu odraslih osoba jedino u neuronima.^[7] Sintetiše se u mitochondrijama^[8] iz aspartinske kiseline i acetil-koenzimA A.

Reference

↑ „N-acetylaspartate - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005.. Identification. Pristupljeno 8. 1. 2012.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Simmons, Frondoza et al. 1991 PMID 1754068; Moffett, Namboodiri et al. 1991
↑ Patel, T. B. and J. B. Clark (1979). "Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport." Biochem J 184(3): 539-46.

Literatura

N-Acetylaspartate: A Unique Neuronal Molecule in the Central Nervous System, eds., J.R.Moffett, S.B.Tieman, D.R.Weinberger, J.T.Coyle, and M.A.Namboodiri, pp. 7–26. New York, NY: Springer Science + Business Media, 2006.
Biochemical Support for the "Threshold" Theory of Creativity: A Magnetic Resonance Spectroscopy Study, Rex E. Jung et al., April 22, 2009, 29(16):5319-5325; DOI:10.1523/JNEUROSCI.0588-09.2009

Povezano

Aspartoacilaza

Spoljašnje veze

Portal Hemija

GeneReviews/NCBI/UW/NIH entry on Canavan disease

[1] „N-acetylaspartate - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005.. Identification. Pristupljeno 8. 1. 2012.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[6] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[7] Simmons, Frondoza et al. 1991 PMID 1754068; Moffett, Namboodiri et al. 1991

[8] Patel, T. B. and J. B. Clark (1979). "Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport." Biochem J 184(3): 539-46.

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