N6-Metiladenozin

N6-Metiladenozin
IUPAC ime
Drugi nazivi m6A
Identifikacija
CAS registarski broj 60209-41-8
PubChem[1][2] 102175
ChemSpider[3] 92307
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C11H15N5O4
Molarna masa 281.27 g mol−1



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

N6-Metiladenozin (m6A ) je često prisutan u iRNK i prisutan je u nekim virusima,[4][5] i većini eukariota uključujući sisare,[6][7][8][9] insekte,[10] biljke[11][12][13] i kvasce.[14][15] On je takoše nađen u tRNK, rRNK, i snRNK kao i u nekoliko dugo kodirajućih RNK, poput Xist.[16][17]

Reference

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  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Beemon K, Keith J (June 1977). „Localization of N6-methyladenosine in the Rous sarcoma virus genome”. J. Mol. Biol. 113 (1): 165–79. DOI:10.1016/0022-2836(77)90047-X. PMID 196091. 
  5. ↑ Aloni Y, Dhar R, Khoury G (October 1979). „Methylation of nuclear simian virus 40 RNAs”. J. Virol. 32 (1): 52–60. PMC 353526. PMID 232187. 
  6. ↑ Desrosiers R, Friderici K, Rottman F (October 1974). „Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells”. Proc. Natl. Acad. Sci. U.S.A. 71 (10): 3971–5. DOI:10.1073/pnas.71.10.3971. PMC 434308. PMID 4372599. 
  7. ↑ Adams JM, Cory S (May 1975). „Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA”. Nature 255 (5503): 28–33. DOI:10.1038/255028a0. PMID 1128665. 
  8. ↑ Wei CM, Gershowitz A, Moss B (January 1976). „5'-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA”. Biochemistry 15 (2): 397–401. DOI:10.1021/bi00647a024. PMID 174715. 
  9. ↑ Perry RP, Kelley DE, Friderici K, Rottman F (April 1975). „The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus”. Cell 4 (4): 387–94. DOI:10.1016/0092-8674(75)90159-2. PMID 1168101. 
  10. ↑ Levis R, Penman S (April 1978). „5'-terminal structures of poly(A)+ cytoplasmic messenger RNA and of poly(A)+ and poly(A)- heterogeneous nuclear RNA of cells of the dipteran Drosophila melanogaster”. J. Mol. Biol. 120 (4): 487–515. DOI:10.1016/0022-2836(78)90350-9. PMID 418182. 
  11. ↑ Nichols JL (1979). „In maize poly(A)-containing RNA”. Plant Science Letters 15 (4): 357. DOI:10.1016/0304-4211(79)90141-X. 
  12. ↑ Kennedy TD, Lane BG (June 1979). „Wheat embryo ribonucleates. XIII. Methyl-substituted nucleoside constituents and 5'-terminal dinucleotide sequences in bulk poly(AR)-rich RNA from imbibing wheat embryos”. Can. J. Biochem. 57 (6): 927–31. DOI:10.1139/o79-112. PMID 476526. 
  13. ↑ Zhong S, Li H, Bodi Z, Button J, Vespa L, Herzog M, Fray RG (May 2008). „MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor”. Plant Cell 20 (5): 1278–88. DOI:10.1105/tpc.108.058883. PMC 2438467. PMID 18505803. 
  14. ↑ Clancy MJ, Shambaugh ME, Timpte CS, Bokar JA (October 2002). „Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene”. Nucleic Acids Res. 30 (20): 4509–18. DOI:10.1093/nar/gkf573. PMC 137137. PMID 12384598. 
  15. ↑ Bodi Z, Button JD, Grierson D, Fray RG (September 2010). „Yeast targets for mRNA methylation”. Nucleic Acids Res. 38 (16): 5327–35. DOI:10.1093/nar/gkq266. PMC 2938207. PMID 20421205. 
  16. ↑ Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR (May 2012). „Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3' UTRs and near Stop Codons”. Cell 149 (7): 1635–46. DOI:10.1016/j.cell.2012.05.003. PMID 22608085. 
  17. ↑ Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G (May 2012). „Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq”. Nature 485 (7397): 201–6. DOI:10.1038/nature11112. PMID 22575960. 

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