PRIM1

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Primaza, DNK, polipeptid 1
Identifikatori
Simboli	PRIM1; PRIM1A, p49
Vanjski ID	OMIM: 176635 MGI: 97757 HomoloGene: 730 GeneCards: PRIM1 Gene
EC broj	2.7.7.-
Ontologija gena Molekulska funkcija • DNK vezivanje • aktivnosti DNK primaze • vezivanje metalnih jona Ćelijska komponenta • nukleoplazma • replizom Biološki proces • G1/S prelaz mitotičkog ćelijskog ciklusa • S faza mitotičkog ćelijskog ciklusa • mitotički ćelijski ciklus
Ortolozi
Vrsta	Čovek	Miš
Entrez	5557	19075
Ensembl	ENSG00000198056	ENSMUST00000135580
UniProt	P49642	P33609
Ref. Sekv. (iRNK)	NM_000946	NM_008921.1
Ref. Sekv. (protein)	NP_000937	NP_032947.1
Lokacija (UCSC)	Chr 12: 56.73 - 56.75 Mb	Chr 10: 128.02 - 128.03 Mb
PubMed pretraga	[1]	[2]

Podjedinica 1 DNK primaze je enzim koji je kod ljudi kodiran PRIM1 genom.^[1][2]

Reference

1. Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). „Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12”. Genomics 28 (2): 350–3. DOI:10.1006/geno.1995.1155. PMID 8530050. 
2. „Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa”. 

Literatura

• Stadlbauer F, Brueckner A, Rehfuess C, et al. (1994). „DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.”. Eur. J. Biochem. 222 (3): 781–93. DOI:10.1111/j.1432-1033.1994.tb18925.x. PMID 8026492. 
• Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Coll JM, Hickey RJ, Cronkey EA, et al. (1998). „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome”. Oncol. Res. 9 (11–12): 629–39. PMID 9563011. 
• Schneider A, Smith RW, Kautz AR, et al. (1998). „Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit”. J. Biol. Chem. 273 (34): 21608–15. DOI:10.1074/jbc.273.34.21608. PMID 9705292. 
• Arezi B, Kirk BW, Copeland WC, Kuchta RD (1999). „Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit”. Biochemistry 38 (39): 12899–907. DOI:10.1021/bi9908991. PMID 10504261. 
• Smith RW, Nasheuer HP (2002). „Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180”. FEBS Lett. 527 (1–3): 143–6. DOI:10.1016/S0014-5793(02)03197-6. PMID 12220650. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rush J, Moritz A, Lee KA, et al. (2005). „Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nat. Biotechnol. 23 (1): 94–101. DOI:10.1038/nbt1046. PMID 15592455.