Prokolagenska N-endopeptidaza

Prokolagenska N-endopeptidaza
Identifikatori
EC broj	3.4.24.14
CAS broj	68651-94-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Prokolagenska N-endopeptidaza (EC 3.4.24.14, prokolagen N-terminalna peptidaza, prokolagenska aminopeptidaza, aminoprokolagenska peptidaza, aminoterminalna prokolagenska peptidaza, prokolagenska aminoterminalna proteaza, prokolagenska N-terminalna proteinaza, tip I/II prokolagenska N-proteinaza, tip III prokolagen) je enzim.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje N-propeptidnog lanca kolagena alfa1(I) na Pro-Gln, kao i alfa1(II) i alfa2(I) na Ala-Gln

Ovaj enzim deluje na propeptide tipa I i II kolagena.

Reference

1. Kohn, L.D., Iserky, C., Zupnik, J., Lenaers, A., Lee, G. and Lapiére, C.M. (1974). „Calf tendon procollagen peptidase: its purification and endopeptidase mode of action”. Proc. Natl. Acad. Sci. USA 71: 40-44. PMID 4204204. 
2. Hojima, Y., McKenzie, J., van der Rest, M. and Prockop, D.J. (1989). „Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides”. J. Biol. Chem. 264: 11336-11345. PMID 2500439. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH Procollagen+N-endopeptidase