RGS18

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Regulator G-proteinske signalizacije 18
PDB prikay baziran na 2dlv.
Dostupne strukture
2DLV, 2JM5, 2OWI
Identifikatori
Simboli	RGS18; RGS13
Vanjski ID	OMIM: 607192 MGI: 1927498 HomoloGene: 11281 GeneCards: RGS18 Gene
Ontologija gena Molekulska funkcija • aktivnost aktivatora GTPaze Ćelijska komponenta • citoplazma • ćelijska membrana Biološki proces • signalni put G-protein spregnutog receptora • terminacija signalnog puta G-protein spregnutog receptora • pozitivna regulacija GTPazne aktivnosti
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	64407	64214
Ensembl	ENSG00000150681	ENSMUSG00000026357
UniProt	Q9NS28	Q99PG4
Ref. Sekv. (iRNK)	NM_130782	NM_022881
Ref. Sekv. (protein)	NP_570138	NP_075019
Lokacija (UCSC)	Chr 1: 192.13 - 192.15 Mb	Chr 1: 144.75 - 144.78 Mb
PubMed pretraga	[1]	[2]

Regulator G-proteinske signalizacije 18 je protein koji je kod ljudi kodiran RGS18 genom.^[1][2]

Ovaj gen kodira člana familije regulatora G-proteinske signalizacije. Taj protein sadrži konzervirani 120 aminokiselina dug motiv, koji se naziva RGS domen. RGS18 umanjuje signalnu aktivnost G-proteina putem vezivanja za aktivirane, GTP-vezane G alfa podjedinice, i tako što deluje kao aktivirajući protein GTPaze (GAP), čime povećava stopu konverzije GTP u GDP. Ova hidroliza omogućava G alfa podjedinicama da vežu G beta/gama heterodimere, čime se formiraju neaktivni G-proteinski heterotrimeri, i time se prekida signal. Alternatne transkripcione splajsne varijante ovog gena su poznate, ali nisu detaljno okarakterisane.^[2]

Interakcije

RGS18 formira interakcije sa GNAI3.^[3][4]

Reference

1. Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF (March 2001). „Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells”. J Biol Chem 276 (2): 915–23. DOI:10.1074/jbc.M005947200. PMID 11042171. 
2. „Entrez Gene: RGS18 regulator of G-protein signalling 18”. 
3. Yowe, D; Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie T M, Gutierrez-Ramos C, Hodge M R (October 2001). „RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes”. Biochem. J. (England) 359 (Pt 1): 109–18. DOI:10.1042/0264-6021:3590109. ISSN 0264-6021. PMC 1222126. PMID 11563974. 
4. Gagnon, Alison W; Murray David L; Leadley Robert J (July 2002). „Cloning and characterization of a novel regulator of G protein signalling in human platelets”. Cell. Signal. (England) 14 (7): 595–606. DOI:10.1016/S0898-6568(02)00012-8. ISSN 0898-6568. PMID 11955952. 

Literatura

• Nagata Y, Oda M, Nakata H, et al. (2001). „A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes”. Blood 97 (10): 3051–60. DOI:10.1182/blood.V97.10.3051. PMID 11342430. 
• Yowe D, Weich N, Prabhudas M, et al. (2003). „RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes”. Biochem. J. 359 (Pt 1): 109–18. DOI:10.1042/0264-6021:3590109. PMC 1222126. PMID 11563974. 
• Sierra DA, Gilbert DJ, Householder D, et al. (2002). „Evolution of the regulators of G-protein signaling multigene family in mouse and human”. Genomics 79 (2): 177–85. DOI:10.1006/geno.2002.6693. PMID 11829488. 
• Gagnon AW, Murray DL, Leadley RJ (2002). „Cloning and characterization of a novel regulator of G protein signalling in human platelets”. Cell. Signal. 14 (7): 595–606. DOI:10.1016/S0898-6568(02)00012-8. PMID 11955952. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Gevaert K, Goethals M, Martens L, et al. (2004). „Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides”. Nat. Biotechnol. 21 (5): 566–9. DOI:10.1038/nbt810. PMID 12665801. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Larminie C, Murdock P, Walhin JP, et al. (2004). „Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system”. Brain Res. Mol. Brain Res. 122 (1): 24–34. DOI:10.1016/j.molbrainres.2003.11.014. PMID 14992813. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Aldenhoven J, Chen Y, Moran C (2006). „Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels”. Cytogenet. Genome Res. 112 (3–4): 341F. DOI:10.1159/000089896. PMID 16484797. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). „The DNA sequence and biological annotation of human chromosome 1”. Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414.