Superagonist
U farmakologiji, superagonist je tip agonista čiji maksimalni respons nadmašuje respons endogenog agonista datag receptora, i stoga je njegova efikasnost veća od 100%.[1][2] Na primer goserelin je superagonist receptora gonadotropin oslobađajućeg hormona.
- ↑ Carlier PR, Chow ES, Barlow RL, Bloomquist JR (August 2002). „Discovery of non-zwitterionic GABAA receptor full agonists and a superagonist”. Bioorg. Med. Chem. Lett. 12 (15): 1985–8. DOI:10.1016/S0960-894X(02)00299-8. PMID 12113824.
- ↑ Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE (September 2002). „Heterozygous α2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists”. Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12471–6. DOI:10.1073/pnas.122368499. PMC 129469. PMID 12205290.