Tiopurin S-metiltransferaza
| Tiopurin S-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.1.1.67 | ||||||||
| CAS broj | 67339-09-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Tiopurin S-metiltransferaza (EC 2.1.1.67, merkaptopurinska metiltransferaza, tiopurinska metiltransferaza, 6-tiopurinska transmetilaza, TPMT) je enzim sa sistematskim imenom S-adenozil-L-metionin:tiopurin S-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + tiopurin S-adenozil-L-homocistein + tiopurin S-metilther
Ovaj enzim takođe u izvesnoj meri deluje na tiopirimidine i aromatične tiole. On nije identičan sa EC 2.1.1.9, tiol S-metiltransferazom.
- ↑ Remy, C.N. (1963). „Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues”. J. Biol. Chem. 238: 1078-1084. PMID 13981612.
- ↑ Woodson, L.C., Ames, M.M., Selassie, C.D, Hansch, C. and Weinshilbaum, R.M. (1983). „Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives”. Mol. Pharmacol. 24: 471-478. PMID 6633508.
- ↑ Woodson, L.C. and Weinshilbaum, R.M. (1983). „Human kidney thiopurine methyltransferase. Purification and biochemical properties”. Biochem. Pharmacol. 32: 819-826. PMID 6838629.
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