Tirozinska proteinska kinaza Lyn

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LYN proto-onkogen, Src familija tirozinskih kinaza
PDB prikaz baziran na 1wa7.
Dostupne strukture
1W1F, 1WA7, 3A4O
Identifikatori
Simboli	LYN; JTK8; p53Lyn; p56Lyn
Vanjski ID	OMIM: 165120 MGI: 96892 HomoloGene: 55649 GeneCards: LYN Gene
EC broj	2.7.10.2
Ontologija gena Molekulska funkcija • aktivnost proteinske tirozinske kinaze • aktivnost nemembranske proteinske tirozinske kinaze • integrinsko vezivanje Ćelijska komponenta • nukleus • citoplazma • mitohondrijski intermembranski prostor Biološki proces • B ćelijska homeostaza • regulacija citokinske produkcije • regulacija proteinske fosforilacije
Ortolozi
Vrsta	Čovek	Miš
Entrez	4067	17096
Ensembl	ENSG00000254087	ENSMUSG00000042228
UniProt	P07948	P25911
Ref. Sekv. (iRNK)	NM_001111097	NM_001111096
Ref. Sekv. (protein)	NP_001104567	NP_001104566
Lokacija (UCSC)	Chr 8: 56.79 - 56.92 Mb	Chr 4: 3.68 - 3.81 Mb
PubMed pretraga	[1]	[2]

Tirozinska proteinska kinaza Lyn je protein koji je kod ljudi kodiran LYN genom.^[1]

Lin je član Src familije proteinskih tirozinskih kinaza, koja je uglavnom izražena u hematopoietskim ćelijama,^[2] u nervnom tkivu^[3] jetri, i adipoznom tkivu.^[4] U raznim hematopoietskim ćelijama, Lyn je ključni enzim koji učestvuje u regulaciji ćelijske aktivacije. U tim ćelijama, male količina LYN'a su asocirane sa receptorskim proteinima na ćelijskoj površini, uključujući B ćelijski antigenski receptor (BCR),^[5][6] CD40,^[7] ili CD19.^[8]

Interakcije

LYN formira interakcije sa:

• BCAR1,^[9][10]
• CD117,^[11][12]
• CD22,^[13][14]
• Cdk1,^[15][16]
• DOK1,^[11][17]
• EPOR^[18]
• GPVI,^[19]
• INPP5D,^[20]
• IRS1,^[21]
• LCP2,^[22]
• MUC1,^[23]
• NEDD9,^[9]
• PLCG2,^[24][25]
• PPP1R15A,^[26]
• PTPRC,^[27]
• Syk,^[28]
• TRPV4,^[29] and
• UNC119.^[30]

Povezano

• Lyn-CD22-SHP-1 put

Reference

1. Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, Yamamoto T, Toyoshima K (January 1987). „The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck”. Mol. Cell. Biol. 7 (1): 237–43. PMC 365062. PMID 3561390. 
2. Yamanashi Y, Mori S, Yoshida M, et al. (September 1989). „Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I”. Proc. Natl. Acad. Sci. U.S.A. 86 (17): 6538–42. DOI:10.1073/pnas.86.17.6538. PMC 297879. PMID 2505253. 
3. Umemori H, Wanaka A, Kato H, Takeuchi M, Tohyama M, Yamamoto T (December 1992). „Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system”. Brain Res. Mol. Brain Res. 16 (3–4): 303–10. DOI:10.1016/0169-328X(92)90239-8. PMID 1337939. 
4. Yamada E, Pessin J, Kurland I, Schwartz G, Bastie C (February 2010). „Fyn-dependent regulation of energy expediture and body weight is mediated by tyrosine phosphorylation of LKB1”. Cell Metab. 11 (2): 113–124. DOI:10.1016/j.cmet.2009.12.010. PMC 2830006. PMID 20142099. 
5. Yamamoto T, Yamanashi Y, Toyoshima K (April 1993). „Association of Src-family kinase Lyn with B-cell antigen receptor”. Immunol. Rev. 132: 187–206. DOI:10.1111/j.1600-065X.1993.tb00843.x. PMID 8349296. 
6. Campbell MA, Sefton BM (May 1992). „Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases”. Mol. Cell. Biol. 12 (5): 2315–21. PMC 364403. PMID 1569953. 
7. Ren CL, Morio T, Fu SM, Geha RS (February 1994). „Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2”. J. Exp. Med. 179 (2): 673–80. DOI:10.1084/jem.179.2.673. PMC 2191357. PMID 7507510. 
8. Campbell 1999
9. Manié SN, Beck AR, Astier A, Law SF, Canty T, Hirai H, Druker BJ, Avraham H, Haghayeghi N, Sattler M, Salgia R, Griffin JD, Golemis EA, Freedman AS (February 1997). „Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells”. J. Biol. Chem. 272 (7): 4230–6. DOI:10.1074/jbc.272.7.4230. PMID 9020138. 
10. Qiu W, Cobb RR, Scholz W (May 1998). „Inhibition of p130cas tyrosine phosphorylation by calyculin A”. J. Leukoc. Biol. 63 (5): 631–5. PMID 9581808. 
11. Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (April 2002). „Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling”. J. Biol. Chem. 277 (16): 13732–8. DOI:10.1074/jbc.M200277200. PMID 11825908. 
12. Linnekin D, DeBerry CS, Mou S (October 1997). „Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells”. J. Biol. Chem. 272 (43): 27450–5. DOI:10.1074/jbc.272.43.27450. PMID 9341198. 
13. Poe JC, Fujimoto M, Jansen PJ, Miller AS, Tedder TF (June 2000). „CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux”. J. Biol. Chem. 275 (23): 17420–7. DOI:10.1074/jbc.M001892200. PMID 10748054. 
14. Greer SF, Justement LB (May 1999). „CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1”. J. Immunol. 162 (9): 5278–86. PMID 10228003. 
15. Kharbanda S, Yuan ZM, Rubin E, Weichselbaum R, Kufe D (August 1994). „Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation”. J. Biol. Chem. 269 (32): 20739–43. PMID 8051175. 
16. Pathan NI, Geahlen RL, Harrison ML (November 1996). „The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2”. J. Biol. Chem. 271 (44): 27517–23. DOI:10.1074/jbc.271.44.27517. PMID 8910336. 
17. van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). „Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells”. Blood 96 (10): 3406–13. PMID 11071635. 
18. Chin H, Arai A, Wakao H, Kamiyama R, Miyasaka N, Miura O (May 1998). „Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway”. Blood 91 (10): 3734–45. PMID 9573010. 
19. Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP (June 2002). „Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling”. J. Biol. Chem. 277 (24): 21561–6. DOI:10.1074/jbc.M201012200. PMID 11943772. 
20. Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G, Marsh CB (October 2003). „The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity”. J. Biol. Chem. 278 (40): 38628–36. DOI:10.1074/jbc.M305021200. PMID 12882960. 
21. Müller G, Wied S, Frick W (July 2000). „Cross talk of pp125(FAK) and pp59(Lyn) non-receptor tyrosine kinases to insulin-mimetic signaling in adipocytes”. Mol. Cell. Biol. 20 (13): 4708–23. DOI:10.1128/mcb.20.13.4708-4723.2000. PMC 85892. PMID 10848597. 
22. Gross BS, Lee JR, Clements JL, Turner M, Tybulewicz VL, Findell PR, Koretzky GA, Watson SP (February 1999). „Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets”. J. Biol. Chem. 274 (9): 5963–71. DOI:10.1074/jbc.274.9.5963. PMID 10026222. 
23. Durum SK, Aiello FB (2003). „Interleukin-7 induces MUC1”. Cancer Biol. Ther. 2 (2): 194–5. DOI:10.4161/cbt.2.2.351. PMID 12750562. 
24. Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC (September 1993). „Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase”. Mol. Cell. Biol. 13 (9): 5877–87. PMC 360336. PMID 8395016. 
25. Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ (August 2000). „Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex”. Immunity 13 (2): 243–53. DOI:10.1016/s1074-7613(00)00024-8. PMID 10981967. 
26. Grishin AV, Azhipa O, Semenov I, Corey SJ (August 2001). „Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis”. Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10172–7. DOI:10.1073/pnas.191130798. PMC 56934. PMID 11517336. 
27. Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB (June 1994). „Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45”. J. Biol. Chem. 269 (25): 17238–44. PMID 7516335. 
28. Sidorenko SP, Law CL, Chandran KA, Clark EA (January 1995). „Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoprotein”. Proc. Natl. Acad. Sci. U.S.A. 92 (2): 359–63. DOI:10.1073/pnas.92.2.359. PMC 42739. PMID 7831290. 
29. Xu H, Zhao H, Tian W, Yoshida K, Roullet JB, Cohen DM (March 2003). „Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress”. J. Biol. Chem. 278 (13): 11520–7. DOI:10.1074/jbc.M211061200. PMID 12538589. 
30. Cen O, Gorska MM, Stafford SJ, Sur S, Alam R (March 2003). „Identification of UNC119 as a novel activator of SRC-type tyrosine kinases”. J. Biol. Chem. 278 (10): 8837–45. DOI:10.1074/jbc.M208261200. PMID 12496276. 

Literatura

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• Hibbs ML, Dunn AR (1997). „Lyn, a src-like tyrosine kinase”. Int. J. Biochem. Cell Biol. 29 (3): 397–400. DOI:10.1016/S1357-2725(96)00104-5. PMID 9202419. 
• Blasioli J, Goodnow CC (2002). „Signal Transduction Pathways in Autoimmunity. Lyn/CD22/SHP-1 and Their Importance in Autoimmunity”. Curr. Dir. Autoimmun.. Current Directions in Autoimmunity 5: 151–60. DOI:10.1159/000060551. ISBN 3-8055-7308-1. PMID 11826756. 
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