XRCC1

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XRCC1
PDB prikaz baziran na 1cdz.
Dostupne strukture
1CDZ, 1XNA, 1XNT, 2D8M, 2W3O, 3K75, 3K77, 3LQC
Identifikatori
Simboli	XRCC1; RCC
Vanjski ID	OMIM: 194360 MGI: 99137 HomoloGene: 31368 GeneCards: XRCC1 Gene
Ontologija gena Molekularna funkcija • vezivanje za oštećenu DNK • proteinsko vezivanje Celularna komponenta • intracelularni • nukleus • nukleoplazma Biološki proces • popravka jednolančanih prekida • respons na hipoksiju • DNK popravka • popravka isecanjem baza • respons na organske supstance • respons na lek
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	7515	22594
Ensembl	ENSG00000073050	ENSMUSG00000051768
UniProt	P18887	Q60596
RefSeq (mRNA)	NM_006297.2	NM_009532.4
RefSeq (protein)	NP_006288.2	NP_033558.3
Lokacija (UCSC)	Chr 19: 44.05 - 44.08 Mb	Chr 7: 25.33 - 25.36 Mb
PubMed pretraga	[1]	[2]

XRCC1 je protein popravke DNK. On formira kompleks sa DNK ligazom III.

Ovaj protein učestvuje u popravci jednolančankih prekida DNK formiranih izlaganjem jonizujućoj radijaciji i alkilujućim agensima. Ovaj protein formira interakcije sa DNK ligazom III, polimerazom beta i poli ADP-riboznom polimerazom da bi učestvovao u putu popravke isecanjem baza. Moguće je da ima ulogu u DNK manipulacijama tokom mejoze i rekombinacije u ćelijama zametka. Retki mikrosatelitni polimorfizam ovog genu je vezan za pojavu pojedinih tipova kancera.^[1]

Interakcije

XRCC1 formira interakcije sa PARP2,^[2] DNK polimerazom beta,^[3][4][5][6] Aprataksinom,^[7][8] Oksoguaninskom glikosilaza,^[9] PCNA,^[4] APEX1,^[10] PNKP^[11][12] i PARP1.^[8][13]

Reference

1. „Entrez Gene: XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1”. 
2. Schreiber, Valérie; Amé Jean-Christophe, Dollé Pascal, Schultz Inès, Rinaldi Bruno, Fraulob Valérie, Ménissier-de Murcia Josiane, de Murcia Gilbert (June 2002). „Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1”. J. Biol. Chem. (United States) 277 (25): 23028–36. DOI:10.1074/jbc.M202390200. ISSN 0021-9258. PMID 11948190. 
3. Wang, Liming; Bhattacharyya Nandan, Chelsea Diane M, Escobar Pedro F, Banerjee Sipra (November 2004). „A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype”. Cancer Res. (United States) 64 (21): 7673–7. DOI:10.1158/0008-5472.CAN-04-2801. ISSN 0008-5472. PMID 15520167. 
4. Fan, Jinshui; Otterlei Marit, Wong Heng-Kuan, Tomkinson Alan E, Wilson David M (2004). „XRCC1 co-localizes and physically interacts with PCNA”. Nucleic Acids Res. (England) 32 (7): 2193–201. DOI:10.1093/nar/gkh556. PMC 407833. PMID 15107487. 
5. Kubota, Y; Nash R A, Klungland A, Schär P, Barnes D E, Lindahl T (December 1996). „Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein”. EMBO J. (ENGLAND) 15 (23): 6662–70. ISSN 0261-4189. PMC 452490. PMID 8978692. 
6. Bhattacharyya, N; Banerjee S (July 2001). „A novel role of XRCC1 in the functions of a DNA polymerase beta variant”. Biochemistry (United States) 40 (30): 9005–13. DOI:10.1021/bi0028789. ISSN 0006-2960. PMID 11467963. 
7. Date, Hidetoshi; Igarashi Shuichi, Sano Yasuteru, Takahashi Toshiaki, Takahashi Tetsuya, Takano Hiroki, Tsuji Shoji, Nishizawa Masatoyo, Onodera Osamu (December 2004). „The FHA domain of aprataxin interacts with the C-terminal region of XRCC1”. Biochem. Biophys. Res. Commun. (United States) 325 (4): 1279–85. DOI:10.1016/j.bbrc.2004.10.162. ISSN 0006-291X. PMID 15555565. 
8. Gueven, Nuri; Becherel Olivier J, Kijas Amanda W, Chen Philip, Howe Orla, Rudolph Jeanette H, Gatti Richard, Date Hidetoshi, Onodera Osamu, Taucher-Scholz Gisela, Lavin Martin F (May 2004). „Aprataxin, a novel protein that protects against genotoxic stress”. Hum. Mol. Genet. (England) 13 (10): 1081–93. DOI:10.1093/hmg/ddh122. ISSN 0964-6906. PMID 15044383. 
9. Marsin, Stéphanie; Vidal Antonio E, Sossou Marguerite, Ménissier-de Murcia Josiane, Le Page Florence, Boiteux Serge, de Murcia Gilbert, Radicella J Pablo (November 2003). „Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1”. J. Biol. Chem. (United States) 278 (45): 44068–74. DOI:10.1074/jbc.M306160200. ISSN 0021-9258. PMID 12933815. 
10. Vidal, A E; Boiteux S, Hickson I D, Radicella J P (November 2001). „XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions”. EMBO J. (England) 20 (22): 6530–9. DOI:10.1093/emboj/20.22.6530. ISSN 0261-4189. PMC 125722. PMID 11707423. 
11. Whitehouse, C J; Taylor R M, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko D D, Weinfeld M, Caldecott K W (January 2001). „XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair”. Cell (United States) 104 (1): 107–17. DOI:10.1016/S0092-8674(01)00195-7. ISSN 0092-8674. PMID 11163244. 
12. Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. (England) 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
13. Masson, M; Niedergang C, Schreiber V, Muller S, Menissier-de Murcia J, de Murcia G (June 1998). „XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage”. Mol. Cell. Biol. (UNITED STATES) 18 (6): 3563–71. ISSN 0270-7306. PMC 108937. PMID 9584196. 

Literatura

• Hung RJ, Hall J, Brennan P, Boffetta P (2006). „Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.”. Am. J. Epidemiol. 162 (10): 925–42. DOI:10.1093/aje/kwi318. PMID 16221808. 
• Thompson LH, Brookman KW, Jones Nj, et al. (1991). „Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.”. Mol. Cell. Biol. 10 (12): 6160–71. PMC 362891. PMID 2247054. 
• Thompson LH, Bachinski LL, Stallings RL, et al. (1990). „Complementation of repair gene mutations on the hemizygous chromosome 9 in CHO: a third repair gene on human chromosome 19.”. Genomics 5 (4): 670–9. DOI:10.1016/0888-7543(89)90107-9. PMID 2591959. 
• Gyapay G, Morissette J, Vignal A, et al. (1994). „The 1993-94 Généthon human genetic linkage map.”. Nat. Genet. 7 (2 Spec No): 246–339. DOI:10.1038/ng0694supp-246. PMID 7545953. 
• Wei Q, Xu X, Cheng L, et al. (1995). „Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR.”. Cancer Res. 55 (21): 5025–9. PMID 7585546. 
• Lamerdin JE, Montgomery MA, Stilwagen SA, et al. (1995). „Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions.”. Genomics 25 (2): 547–54. DOI:10.1016/0888-7543(95)80056-R. PMID 7789989. 
• Caldecott KW, McKeown CK, Tucker JD, et al. (1994). „An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.”. Mol. Cell. Biol. 14 (1): 68–76. PMC 358357. PMID 8264637. 
• Trask B, Fertitta A, Christensen M, et al. (1993). „Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.”. Genomics 15 (1): 133–45. DOI:10.1006/geno.1993.1021. PMID 8432525. 
• Kubota Y, Nash RA, Klungland A, et al. (1997). „Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.”. EMBO J. 15 (23): 6662–70. PMC 452490. PMID 8978692. 
• Nash RA, Caldecott KW, Barnes DE, Lindahl T (1997). „XRCC1 protein interacts with one of two distinct forms of DNA ligase III.”. Biochemistry 36 (17): 5207–11. DOI:10.1021/bi962281m. PMID 9136882. 
• Shen MR, Jones IM, Mohrenweiser H (1998). „Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.”. Cancer Res. 58 (4): 604–8. PMID 9485007. 
• Price EA, Bourne SL, Radbourne R, et al. (1998). „Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity.”. Somat. Cell Mol. Genet. 23 (4): 237–47. DOI:10.1007/BF02674415. PMID 9542526. 
• Masson M, Niedergang C, Schreiber V, et al. (1998). „XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage.”. Mol. Cell. Biol. 18 (6): 3563–71. PMC 108937. PMID 9584196. 
• Taylor RM, Wickstead B, Cronin S, Caldecott KW (1998). „Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1.”. Curr. Biol. 8 (15): 877–80. DOI:10.1016/S0960-9822(07)00350-8. PMID 9705932. 
• Zhou ZQ, Walter CA (1998). „Cloning and characterization of the promoter of baboon XRCC1, a gene involved in DNA strand-break repair.”. Somat. Cell Mol. Genet. 24 (1): 23–39. DOI:10.1007/BF02677493. PMID 9776979. 
• Taylor RM, Moore DJ, Whitehouse J, et al. (2000). „A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair.”. Mol. Cell. Biol. 20 (2): 735–40. DOI:10.1128/MCB.20.2.735-740.2000. PMC 85188. PMID 10611252. 
• Marintchev A, Robertson A, Dimitriadis EK, et al. (2000). „Domain specific interaction in the XRCC1-DNA polymerase beta complex.”. Nucleic Acids Res. 28 (10): 2049–59. DOI:10.1093/nar/28.10.2049. PMC 105377. PMID 10773072. 
• Duell EJ, Wiencke JK, Cheng TJ, et al. (2000). „Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.”. Carcinogenesis 21 (5): 965–71. DOI:10.1093/carcin/21.5.965. PMID 10783319. 
• Whitehouse CJ, Taylor RM, Thistlethwaite A, et al. (2001). „XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.”. Cell 104 (1): 107–17. DOI:10.1016/S0092-8674(01)00195-7. PMID 11163244. 
• Dulic A, Bates PA, Zhang X, et al. (2001). „BRCT domain interactions in the heterodimeric DNA repair protein XRCC1-DNA ligase III.”. Biochemistry 40 (20): 5906–13. DOI:10.1021/bi002701e. PMID 11352725. 

Vanjske veze

• MeSH X-ray+repair+cross+complementing+protein+1