Central line or Central Line may refer to:
- Central Line (Cape Town), a commuter rail service in Cape Town, South Africa
- Central line (London Underground), a line northwest/west to northeast through central London, England
- Central line (Mumbai Suburban Railway), a public transit system serving Mumbai, Maharashtra, India
- Central Line (Newark), a former streetcar line in New Jersey, United States
- Central Line (Sweden), a railway line between Sundsvall and Storlien
- Central Line (Tanzania), a rail line that runs west from Dar es Salaam to Kigoma
- Central Link, a light rail service in Seattle, Washington, United States
- Central Subway, a light rail service in San Francisco, California, United States
- Chūō Line (Central Line), one of several train lines in Japan
- Jungang Line (disambiguation) (Korean Central Line railways)
- Moscow Central Circle, a commuter line encircling central Moscow, Russia