Altizid
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| Nazivi | |
|---|---|
| IUPAC naziv
(3R)-3-[(Alilsulfanil)metil]-6-hloro-3,4-dihidro-2H-1,2,4-benzotiadiazin-7-sulfonamid 1,1-dioksid
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Drugi nazivi
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| Identifikacija | |
3D model (Jmol)
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| ChemSpider | |
| ECHA InfoCard | 100.024.541 |
| KEGG[1] | |
| UNII | |
| |
| Svojstva | |
| C11H14ClN3O4S3 | |
| Molarna masa | 383,895 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
| Reference infokutije | |
Altizid je tiazidni diuretik. Zajedno sa spironolaktonom, on je u prodaji pod nazivima Aldaktakin i Aldaktazin od strane kompanije Pfizer, kao i pod nizom drugih imena od strane drugih kompanija.[4]
Sinteza
[уреди | уреди извор]
Osobine
[уреди | уреди извор]Altizid je organsko jedinjenje, koje sadrži 11 atoma ugljenika i ima molekulsku masu od 383,895 Da.
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 6 |
| Broj donora vodonika | 3 |
| Broj rotacionih veza | 5 |
| Particioni koeficijent[5] (ALogP) | 1,2 |
| Rastvorljivost[6] (logS, log(mol/L)) | -3,8 |
| Polarna površina[7] (PSA, Å2) | 160,4 |
Reference
[уреди | уреди извор]- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ „Altizide”. drugs.com.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (I изд.). Oxford University Press. ISBN 978-0-19-850346-0.
- Smith, Michael B.; March, Jerry (2007). Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th изд.). New York: Wiley-Interscience. ISBN 0-471-72091-7.
- Katritzky A.R.; Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry (Second изд.). Academic Press. ISBN 0080429882.
