Aminodezoksihorizmat sintaza
| Aminodezoksihorizmat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.85 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aminodezoksihorizmat sintaza (EC 2.6.1.85, ADC sintaza, 4-amino-4-dezoksihorizmatna sintaza, PabB, horizmat:L-glutamin amido-ligaza) je enzim sa sistematskim imenom horizmat:L-glutamin aminotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim se sastoji od dva dela, PabA i PabB. U odsustvu PabA i glutamina, PabB konvertuje amonijak i horizmat u 4-amino-4-dezoksihorizmat (u prisustvu Mg2+). PabA konvertuje glutamin u glutamat samo kad je prisutna stohiometrijka količina PabB. Ovaj enzim se spreže sa EC 4.1.3.38, aminodezoksihorizmatnom lijazom, da formira 4-aminobenzoat.
Reference
[уреди | уреди извор]- ^ Ye, Q.Z., Liu, J. and Walsh, C.T. (1990). „p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase”. Proc. Natl. Acad. Sci. USA. 87: 9391—9395. PMID 2251281.
- ^ Viswanathan, V.K., Green, J.M. and Nichols, B.P. (1995). „Kinetic characterization of 4-amino 4-deoxychorismate synthase from Escherichia coli”. J. Bacteriol. 177: 5918—5923. PMID 7592344.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Aminodeoxychorismate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
