B3GAT3

B3GAT3
Available structures PDB Pretraga ortologa: PDBe RCSB List of PDB id codes 1FGG, 1KWS, 3CU0
Identifikatori
Alijasi	B3GAT3
Spoljašnji ID	OMIM: 606374 MGI: 1919977 HomoloGene: 56554 GeneCards: B3GAT3
Genska lokacija (miš) Hr. Chromosome 19 (mouse)[1] Band 19|19 A Start 8,897,738 bp[1] Kraj 8,904,600 bp[1]
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • transferase activity • protein phosphatase activator activity • glucuronosyltransferase activity • metal ion binding • GO:0001948, GO:0016582 везивање за протеине плазме • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Cellular component • саставни део мембране • Голџијев апарат • мембрана • cis-Golgi network • extracellular exosome • Golgi membrane Biological process • positive regulation of intracellular protein transport • glycosaminoglycan metabolic process • heparan sulfate proteoglycan biosynthetic process • GO:0048554 positive regulation of catalytic activity • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • glycosaminoglycan biosynthetic process • chondroitin sulfate proteoglycan biosynthetic process • dermatan sulfate proteoglycan biosynthetic process • chondroitin sulfate metabolic process • Метаболизам угљених хидрата • regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	26229	72727
Ensembl	ENSG00000149541	ENSMUSG00000071649
UniProt	O94766	P58158
RefSeq (mRNA)	NM_001288721 NM_001288722 NM_001288723 NM_012200	NM_024256
RefSeq (protein)	NP_001275650 NP_001275651 NP_001275652 NP_036332	NP_077218
Location (UCSC)	n/a	Chr 19: 8.9 – 8.9 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Galaktozilgalaktozilksilozilprotein 3-beta-glukuronoziltransferaza 3 je enzim koji je kod ljudi kodiran genom B3GAT3.^[4][5]

Protein kodiran ovim genom je član porodice gena glukuroniltransferaze, enzima koji pokazuju strogu specifičnost akceptora, prepoznajući nereducirajuće terminalne šećere i njihove anomerne veze. Ovaj genski proizvod katalizuje formiranje veze glikozaminoglikan-protein putem reakcije transfera glukuronila u završnom koraku biosinteze regiona veze proteoglikana.^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000071649 - Ensembl, May 2017
2. „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
3. „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K (април 1998). „Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans”. J Biol Chem. 273 (12): 6615—8. PMID 9506957. doi:10.1074/jbc.273.12.6615 . CS1 одржавање: Формат датума (веза)
5. „Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)”. 

Literatura

• Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature. 437 (7062): 1173—8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209. 
• Venkatesan N, Barré L, Benani A, et al. (2005). „Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: A strategy to promote cartilage repair”. Proc. Natl. Acad. Sci. U.S.A. 101 (52): 18087—92. PMC 535800 . PMID 15601778. doi:10.1073/pnas.0404504102 . 
• Gulberti S, Lattard V, Fondeur M, et al. (2005). „Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans”. J. Biol. Chem. 280 (2): 1417—25. PMID 15522873. doi:10.1074/jbc.M411552200 . 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. 
• Gulberti S, Fournel-Gigleux S, Mulliert G, et al. (2003). „The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif”. J. Biol. Chem. 278 (34): 32219—26. PMID 12794088. doi:10.1074/jbc.M207899200 . 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 . 
• Kitagawa H, Taoka M, Tone Y, Sugahara K (2001). „Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization”. Biochem. J. 358 (Pt 3): 539—46. PMC 1222090 . PMID 11535117. doi:10.1042/0264-6021:3580539. 
• Pedersen LC, Tsuchida K, Kitagawa H, et al. (2000). „Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I”. J. Biol. Chem. 275 (44): 34580—5. PMID 10946001. doi:10.1074/jbc.M007399200 . 
• Ouzzine M, Gulberti S, Netter P, et al. (2000). „Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues”. J. Biol. Chem. 275 (36): 28254—60. PMID 10842173. doi:10.1074/jbc.M002182200 . 
• Tone Y, Kitagawa H, Imiya K, et al. (1999). „Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans”. FEBS Lett. 459 (3): 415—20. PMID 10526176. S2CID 7878952. doi:10.1016/S0014-5793(99)01287-9 . 
• Herman T, Horvitz HR (1999). „Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway”. Proc. Natl. Acad. Sci. U.S.A. 96 (3): 974—9. Bibcode:1999PNAS...96..974H. PMC 15335 . PMID 9927678. doi:10.1073/pnas.96.3.974 . 

Spoljašnje veze

• Human B3GAT3 genome location and B3GAT3 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O94766 (Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)) at the PDBe-KB.