CHST6

CHST6
Identifikatori
Alijasi	CHST6
Spoljašnji ID	OMIM: 605294 MGI: 1931825 HomoloGene: 56927 GeneCards: CHST6
Genska lokacija (miš) Hr. Chromosome 8 (mouse)[1] Band 8|8 E1 Start 112,615,768 bp[1] Kraj 112,637,079 bp[1]
Genska ontologija Molecular function • sulfotransferase activity • transferase activity • N-acetylglucosamine 6-O-sulfotransferase activity Cellular component • Голџијев апарат • Golgi membrane • мембрана • саставни део мембране • trans-Golgi network Biological process • sulfur compound metabolic process • keratan sulfate biosynthetic process • N-acetylglucosamine metabolic process • Метаболизам угљених хидрата Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	4166	56773
Ensembl	ENSG00000183196	ENSMUSG00000031952
UniProt	Q9GZX3	Q9QUP4
RefSeq (mRNA)	NM_021615	NM_019950
RefSeq (protein)	NP_067628	NP_064334
Location (UCSC)	n/a	Chr 8: 112.62 – 112.64 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Ugljeno hidratna sulfotransferaza 6 (eng. Carbohydrate sulfotransferase 6) je enzim koji je kod ljudi kodiran istoimenim genom CHST6^[4][5][6] , nalazi se na kratkom kraku 16 hromozoma.^[7] Dužina polipeptidnog lanca je 395 aminokiselina, a molekulska težina 44.099.^[8]

Reference

1. GRCm38: Ensembl release 89: ENSMUSG00000031952 - Ensembl, May 2017
2. „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
3. „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. Vance JM, Jonasson F, Lennon F, Sarrica J, Damji KF, Stauffer J, Pericak-Vance MA, Klintworth GK (јул 1996). „Linkage of a gene for macular corneal dystrophy to chromosome 16”. Am J Hum Genet. 58 (4): 757—62. PMC 1914688 . PMID 8644739. CS1 одржавање: Формат датума (веза)
5. Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN (новембар 2000). „Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene”. Nat Genet. 26 (2): 237—41. PMID 11017086. S2CID 25547752. doi:10.1038/79987. CS1 одржавање: Формат датума (веза)
6. „Entrez Gene: CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6”. 
7. „HUGO Gene Nomenclature Commitee, HGNC:6938” (на језику: англ.). Приступљено 11. 09. 2017. CS1 одржавање: Непрепознат језик (веза)^{[мртва веза]}
8. „UniProt, Q9GZX3” (на језику: англ.). Архивирано из оригинала 17. 01. 2016. г. Приступљено 07. 06. 2024. CS1 одржавање: Непрепознат језик (веза)

Literatura

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• Shilatifard A, Merkle RK, Helland DE, et al. (1993). „Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.”. J. Virol. 67 (2): 943—52. PMC 237448 . PMID 8419650. doi:10.1128/JVI.67.2.943-952.1993. 
• Uchimura K, Fasakhany F, Kadomatsu K, et al. (2000). „Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities.”. Biochem. Biophys. Res. Commun. 274 (2): 291—6. PMID 10913333. doi:10.1006/bbrc.2000.3141. 
• Spiro MJ, Spiro RG (2001). „Sulfation of the N-linked oligosaccharides of influenza virus hemagglutinin: temporal relationships and localization of sulfotransferases.”. Glycobiology. 10 (11): 1235—42. PMID 11087716. doi:10.1093/glycob/10.11.1235 . 
• Liu NP, Dew-Knight S, Rayner M, et al. (2001). „Mutations in corneal carbohydrate sulfotransferase 6 gene (CHST6) cause macular corneal dystrophy in Iceland.”. Mol. Vis. 6: 261—4. PMID 11139648. 
• Hemmerich S, Lee JK, Bhakta S, et al. (2001). „Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family.”. Glycobiology. 11 (1): 75—87. PMID 11181564. doi:10.1093/glycob/11.1.75 . 
• Akama TO, Nakayama J, Nishida K, et al. (2001). „Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate.”. J. Biol. Chem. 276 (19): 16271—8. PMID 11278593. doi:10.1074/jbc.M009995200 . 
• Bartes A, Bhakta S, Hemmerich S (2001). „Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta).”. Biochem. Biophys. Res. Commun. 282 (4): 928—33. PMID 11352640. doi:10.1006/bbrc.2001.4668. 
• El-Ashry MF, Abd El-Aziz MM, Wilkins S, et al. (2002). „Identification of novel mutations in the carbohydrate sulfotransferase gene (CHST6) causing macular corneal dystrophy.”. Invest. Ophthalmol. Vis. Sci. 43 (2): 377—82. PMID 11818380. 
• Akama TO, Misra AK, Hindsgaul O, Fukuda MN (2003). „Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.”. J. Biol. Chem. 277 (45): 42505—13. PMID 12218059. doi:10.1074/jbc.M207412200 . 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 . 
• Niel F, Ellies P, Dighiero P, et al. (2003). „Truncating mutations in the carbohydrate sulfotransferase 6 gene (CHST6) result in macular corneal dystrophy.”. Invest. Ophthalmol. Vis. Sci. 44 (7): 2949—53. PMID 12824236. doi:10.1167/iovs.02-0740. 
• Iida-Hasegawa N, Furuhata A, Hayatsu H, et al. (2003). „Mutations in the CHST6 gene in patients with macular corneal dystrophy: immunohistochemical evidence of heterogeneity.”. Invest. Ophthalmol. Vis. Sci. 44 (8): 3272—7. PMID 12882769. doi:10.1167/iovs.02-0910. 
• Ha NT, Chau HM, Cung le X, et al. (2003). „Mutation analysis of the carbohydrate sulfotransferase gene in Vietnamese with macular corneal dystrophy.”. Invest. Ophthalmol. Vis. Sci. 44 (8): 3310—6. PMID 12882775. doi:10.1167/iovs.03-0031. 
• Ha NT, Chau HM, Cung le X, et al. (2003). „Identification of novel mutations of the CHST6 gene in Vietnamese families affected with macular corneal dystrophy in two generations.”. Cornea. 22 (6): 508—11. PMID 12883341. S2CID 25039164. doi:10.1097/00003226-200308000-00004. 
• Warren JF, Aldave AJ, Srinivasan M, et al. (2003). „Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India.”. Arch. Ophthalmol. 121 (11): 1608—12. PMID 14609920. doi:10.1001/archopht.121.11.1608. 
• Sultana A, Sridhar MS, Jagannathan A, et al. (2004). „Novel mutations of the carbohydrate sulfotransferase-6 (CHST6) gene causing macular corneal dystrophy in India.”. Mol. Vis. 9: 730—4. PMID 14735064. 
• Abbruzzese C, Kuhn U, Molina F, et al. (2004). „Novel mutations in the CHST6 gene causing macular corneal dystrophy.”. Clin. Genet. 65 (2): 120—5. PMID 14984470. S2CID 32667901. doi:10.1111/j.0009-9163.2004.00191.x.