GNA13

Guanin nukleotid-vezujući protein (G protein), alfa 13
PDB prikaz baziran na 1zcb.
Dostupne strukture
1zcb​
Identifikatori
Simboli	GNA13; G13; MGC46138
Vanjski ID	OMIM: 604406 MGI: 95768 HomoloGene: 55976 GeneCards: GNA13 Gene
Ontologija gena Molekularna funkcija • vezivanje nukleotida • aktivnost GTPaze • aktivnost receptora signalnih proteina • vezivanje proteina • GTP vezivanje Celularna komponenta • membrana Biološki proces • obrazovaje krvnih sudova • in utero embrionski razvoj • ćelijska motilnost • prenos signala • signalni put G-protein spregnutog receptora • kaskada protein kinaza • Ro protein signalna transdukcija • regulacija ćelijskog oblika • ćelijska diferencijacija • aktivacija trombocita • regulacija ćelijske migracije
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	10672	14674
Ensembl	ENSG00000120063	ENSMUSG00000020611
UniProt	Q14344	Q3UE40
RefSeq (mRNA)	NM_006572	NM_010303
RefSeq (protein)	NP_006563	NP_034433
Lokacija (UCSC)	Chr 17: 60.44 - 60.48 Mb	Chr 11: 109.18 - 109.21 Mb
PubMed pretraga	[1]	[2]

GNA13, Guanin nukleotid-vezujući protein alfa 13 je protein koji je kod ljudi kodiran GNA13 genom.^[1][2]

Interactions

Za GNA12 je bilo pokazano da interaguje sa ARHGEF1,^[3][4] AKAP3,^[5] RIC8A,^[6] Radixin^[7] i ARHGEF12.^[8][9]

Reference

1. Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (1995). „Expression of GTP-binding protein alpha subunits in human thymocytes”. Mol Cell Biochem. 144 (1): 45—51. PMID 7791744. doi:10.1007/BF00926739. 
2. „Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13”. 
3. Bhattacharyya, Raja; Wedegaertner Philip B (2003). „Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment”. FEBS Lett. Netherlands. 540 (1-3): 211—6. ISSN 0014-5793. PMID 12681510. doi:10.1016/S0014-5793(03)00267-9. 
4. Hart, M J; Jiang X; et al. (1998). „Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13”. Science. UNITED STATES. 280 (5372): 2112—4. ISSN 0036-8075. PMID 9641916. doi:10.1126/science.280.5372.2112. 
5. Niu, J; Vaiskunaite R; et al. (2001). „Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation”. Curr. Biol. England. 11 (21): 1686—90. ISSN 0960-9822. PMID 11696326. doi:10.1016/S0960-9822(01)00530-9. 
6. Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200. 
7. Vaiskunaite, R; Adarichev V; et al. (2000). „Conformational activation of radixin by G13 protein alpha subunit”. J. Biol. Chem. UNITED STATES. 275 (34): 26206—12. ISSN 0021-9258. PMID 10816569. doi:10.1074/jbc.M001863200. 
8. Fukuhara, S; Chikumi H; Gutkind J S (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. NETHERLANDS. 485 (2-3): 183—8. ISSN 0014-5793. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9. 
9. Suzuki, Nobuchika; Nakamura Susumu; et al. (2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (2): 733—8. ISSN 0027-8424. PMC 141065 . PMID 12515866. doi:10.1073/pnas.0234057100. 

Literatura

• Ruppel KM; Willison D; Kataoka H; Wang A; Zheng YW; Cornelissen I; Liya Yin; Xu SM & Coughlin SR (2005). „Essential role for Galpha 13 in endothelial cells during embryonic development.”. Proc. Natl. Acad. Sci. U.S.A. 102 (22): 8281—8286. PMC 1149452 . PMID 15919816. doi:10.1073/pnas.0503326102. 
• Downes GB, Gautam N (2000). „The G protein subunit gene families.”. Genomics. 62 (3): 544—52. PMID 10644457. doi:10.1006/geno.1999.5992. 
• Offermanns S, Laugwitz KL, Spicher K, Schultz G (1994). „G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.”. Proc. Natl. Acad. Sci. U.S.A. 91 (2): 504—8. PMC 42977 . PMID 8290554. doi:10.1073/pnas.91.2.504. 
• Laugwitz KL; Allgeier A; Offermanns S; et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116—20. PMC 40189 . PMID 8552586. doi:10.1073/pnas.93.1.116. 
• Offermanns S, Hu YH, Simon MI (1996). „Galpha12 and galpha13 are phosphorylated during platelet activation.”. J. Biol. Chem. 271 (42): 26044—8. PMID 8824244. doi:10.1074/jbc.271.42.26044. 
• Offermanns S, Mancino V, Revel JP, Simon MI (1997). „Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency.”. Science. 275 (5299): 533—6. PMID 8999798. doi:10.1126/science.275.5299.533. 
• Macrez-Leprêtre N; Kalkbrenner F; Morel JL; et al. (1997). „G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes.”. J. Biol. Chem. 272 (15): 10095—102. PMID 9092554. doi:10.1074/jbc.272.15.10095. 
• Hart MJ; Jiang X; Kozasa T; et al. (1998). „Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.”. Science. 280 (5372): 2112—4. PMID 9641916. doi:10.1126/science.280.5372.2112. 
• Fukuhara S; Murga C; Zohar M; et al. (1999). „A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.”. J. Biol. Chem. 274 (9): 5868—79. PMID 10026210. doi:10.1074/jbc.274.9.5868. 
• Becker KP, Garnovskaya M, Gettys T, Halushka PV (1999). „Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling.”. Biochim. Biophys. Acta. 1450 (3): 288—96. PMID 10395940. doi:10.1016/S0167-4889(99)00068-3. 
• Windh RT; Lee MJ; Hla T; et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”. J. Biol. Chem. 274 (39): 27351—8. PMID 10488065. doi:10.1074/jbc.274.39.27351. 
• Brydon L; Roka F; Petit L; et al. (2000). „Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.”. Mol. Endocrinol. 13 (12): 2025—38. PMID 10598579. doi:10.1210/me.13.12.2025. 
• Bhattacharyya R, Wedegaertner PB (2000). „Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding.”. J. Biol. Chem. 275 (20): 14992—9. PMID 10747909. doi:10.1074/jbc.M000415200. 
• Vaiskunaite R; Adarichev V; Furthmayr H; et al. (2000). „Conformational activation of radixin by G13 protein alpha subunit.”. J. Biol. Chem. 275 (34): 26206—12. PMID 10816569. doi:10.1074/jbc.M001863200. 
• Shi CS; Sinnarajah S; Cho H; et al. (2000). „G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription.”. J. Biol. Chem. 275 (32): 24470—6. PMID 10821841. doi:10.1074/jbc.M908449199. 
• Ponimaskin E; Behn H; Adarichev V; et al. (2000). „Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.”. FEBS Lett. 478 (1-2): 173—7. PMID 10922491. doi:10.1016/S0014-5793(00)01845-7. 
• Jin S, Exton JH (2000). „Activation of RhoA by association of Galpha(13) with Dbl.”. Biochem. Biophys. Res. Commun. 277 (3): 718—21. PMID 11062019. doi:10.1006/bbrc.2000.3744. 
• Fukuhara S, Chikumi H, Gutkind JS (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.”. FEBS Lett. 485 (2-3): 183—8. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9. 
• Meigs TE, Fields TA, McKee DD, Casey PJ (2001). „Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.”. Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519—24. PMC 14619 . PMID 11136230. doi:10.1073/pnas.021350998. 

Vidi još

• G protein