GNAI1

Guanin nukleotid-vezujući protein (G protein), alfa inhibirajući polipeptid 1
PDB prikaz baziran na 1agr.
Dostupne strukture
1agr​, 1as0​, 1as2​, 1as3​, 1bh2​, 1bof​, 1cip​, 1gdd​, 1gfi​, 1gg2​, 1gia​, 1gil​, 1git​, 1gp2​, 1kjy​, 1svk​, 1svs​, 1y3a​, 2g83​, 2gtp​, 2hlb​, 2ihb​, 2ik8​, 2ode​
Identifikatori
Simboli	GNAI1; Gi
Vanjski ID	OMIM: 139310 MGI: 95771 HomoloGene: 74417 GeneCards: GNAI1 Gene
Ontologija gena Molekularna funkcija • vezivanje nukleotida • aktivnost GTPaze • aktivnost prenosnika signala • vezivanje proteina • GTP vezivanje Celularna komponenta • heterotrimerni G-proteinski kompleks • membrana plazme Biološki proces • prenos signala • signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2770	14677
Ensembl	ENSG00000127955	ENSMUSG00000057614
UniProt	P63096	n/a
RefSeq (mRNA)	NM_002069	NM_010305
RefSeq (protein)	NP_002060	NP_034435
Lokacija (UCSC)	Chr 7: 79.6 - 79.69 Mb	Chr 5: 17.78 - 17.87 Mb
PubMed pretraga	[1]	[2]

GNAI1, Guanin nukleotid-vezujući protein G(i), alfa-1 podjedinica, je protein koji je kod ljudi kodiran GNAI1 genom.^[1][2]

Interaktivna mapa signalnih puteva

Kliknite na linkove gena, proteina i metabolita da prikažete članke.^[3]

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|{{{bSize}}}px|alt=Nikotin na dopaminergijskim neuronima uredi]]

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Nikotin na dopaminergijskim neuronima uredi

Interakcije

Za GNAI1 je bilo pokazano da ostvaruje interakcije sa GPR143,^[4] RGS14,^[5][6] RIC8A,^[7] S1PR1,^[8] RGS12^[5] i RGS19.^[9][10]

Reference

1. Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (1987). „Human cDNA clones for an alpha subunit of Gi signal-transduction protein”. Proc Natl Acad Sci U S A. 84 (15): 5115—9. PMC 298804 . PMID 3110783. doi:10.1073/pnas.84.15.5115. 
2. „Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1”. 
3. The interactive pathway map can be edited at WikiPathways: „NicotineDopaminergic_WP1602”. 
4. Schiaffino, M V; d'Addio M; et al. (1999). „Ocular albinism: evidence for a defect in an intracellular signal transduction system”. Nat. Genet. UNITED STATES. 23 (1): 108—12. ISSN 1061-4036. PMID 10471510. doi:10.1038/12715. 
5. Kimple, R J; De Vries L; et al. (2001). „RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. J. Biol. Chem. United States. 276 (31): 29275—81. ISSN 0021-9258. PMID 11387333. doi:10.1074/jbc.M103208200. 
6. Kimple, Randall J; Kimple Michelle E; et al. (2002). „Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits”. Nature. England. 416 (6883): 878—81. ISSN 0028-0836. PMID 11976690. doi:10.1038/416878a. 
7. Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200. 
8. Lee, M J; Evans M; Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. J. Biol. Chem. UNITED STATES. 271 (19): 11272—9. ISSN 0021-9258. PMID 8626678. doi:10.1074/jbc.271.19.11272. 
9. Woulfe, D S; Stadel J M (1999). „Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP”. J. Biol. Chem. UNITED STATES. 274 (25): 17718—24. ISSN 0021-9258. PMID 10364213. doi:10.1074/jbc.274.25.17718. 
10. De Vries, L; Elenko E; et al. (1996). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (26): 15203—8. ISSN 0027-8424. PMC 26381 . PMID 8986788. doi:10.1073/pnas.93.26.15203. 

Literatura

• Sidhu A, Niznik HB (2000). „Coupling of dopamine receptor subtypes to multiple and diverse G proteins.”. Int. J. Dev. Neurosci. 18 (7): 669—77. PMID 10978845. doi:10.1016/S0736-5748(00)00033-2. 
• Brown EJ, Frazier WA (2001). „Integrin-associated protein (CD47) and its ligands.”. Trends Cell Biol. 11 (3): 130—5. PMID 11306274. doi:10.1016/S0962-8924(00)01906-1. 
• Raymond JR; Mukhin YV; Gelasco A; et al. (2002). „Multiplicity of mechanisms of serotonin receptor signal transduction.”. Pharmacol. Ther. 92 (2-3): 179—212. PMID 11916537. doi:10.1016/S0163-7258(01)00169-3. 
• Jiang M, Pandey S, Tran VT, Fong HK (1991). „Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.”. Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907—11. PMC 51562 . PMID 1902575. doi:10.1073/pnas.88.9.3907. 
• Gennity JM, Siess W (1991). „Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets.”. Biochem. J. 279 ( Pt 3): 643—50. PMC 1151493 . PMID 1953657. 
• Itoh H; Toyama R; Kozasa T; et al. (1988). „Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.”. J. Biol. Chem. 263 (14): 6656—64. PMID 2834384. 
• Bloch DB; Bloch KD; Iannuzzi M; et al. (1988). „The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus.”. Am. J. Hum. Genet. 42 (6): 884—8. PMC 1715192 . PMID 3130752. 
• Nagata K; Katada T; Tohkin M; et al. (1988). „GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin.”. FEBS Lett. 237 (1-2): 113—7. PMID 3139448. doi:10.1016/0014-5793(88)80182-0. 
• Kagimoto S; Yamada Y; Kubota A; et al. (1994). „Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.”. Biochem. Biophys. Res. Commun. 202 (2): 1188—95. PMID 7914078. doi:10.1006/bbrc.1994.2054. 
• Nitta K; Uchida K; Kawashima A; et al. (1994). „Identification of GTP-binding proteins in human glomeruli.”. Nippon Jinzo Gakkai shi. 36 (1): 9—12. PMID 8107314. 
• Law SF; Zaina S; Sweet R; et al. (1994). „Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.”. Mol. Pharmacol. 45 (4): 587—90. PMID 8183236. 
• Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (1993). „Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.”. Endocrinology. 132 (6): 2484—90. PMID 8504751. doi:10.1210/en.132.6.2484. 
• Laugwitz KL; Allgeier A; Offermanns S; et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116—20. PMC 40189 . PMID 8552586. doi:10.1073/pnas.93.1.116. 
• Andersson B; Wentland MA; Ricafrente JY; et al. (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138. 
• Lee MJ, Evans M, Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.”. J. Biol. Chem. 271 (19): 11272—9. PMID 8626678. doi:10.1074/jbc.271.19.11272. 
• De Vries L; Elenko E; Hubler L; et al. (1997). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.”. Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203—8. PMC 26381 . PMID 8986788. doi:10.1073/pnas.93.26.15203. 
• Yu W; Andersson B; Worley KC; et al. (1997). „Large-scale concatenation cDNA sequencing.”. Genome Res. 7 (4): 353—8. PMC 139146 . PMID 9110174. 
• Popov S, Yu K, Kozasa T, Wilkie TM (1997). „The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.”. Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7216—20. PMC 23796 . PMID 9207071. doi:10.1073/pnas.94.14.7216. 
• Shuey DJ; Betty M; Jones PG; et al. (1998). „RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells.”. J. Neurochem. 70 (5): 1964—72. PMID 9572280. doi:10.1046/j.1471-4159.1998.70051964.x.