HAS3

HAS3
Identifikatori
Alijasi	HAS3
Spoljašnji ID	OMIM: 602428 MGI: 109599 HomoloGene: 68461 GeneCards: HAS3
Genska lokacija (miš) Hr. Chromosome 8 (mouse)[1] Band 8 D3|8 53.28 cM Start 107,596,874 bp[1] Kraj 107,611,198 bp[1]
Genska ontologija Molecular function • transferase activity • glycosyltransferase activity • hyaluronan synthase activity • GO:0001948, GO:0016582 везивање за протеине плазме • identical protein binding Cellular component • цитоплазма • саставни део мембране • ћелијска мембрана • hyaluranon cable • integral component of plasma membrane • мембрана Biological process • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • Ćelijska adhezija • hyaluronan biosynthetic process • extracellular matrix assembly • positive regulation of hyaluranon cable assembly • extracellular polysaccharide biosynthetic process • Метаболизам угљених хидрата Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	3038	15118
Ensembl	ENSG00000103044	ENSMUSG00000031910
UniProt	O00219	O08650
RefSeq (mRNA)	NM_001199280 NM_005329 NM_138612	NM_008217 NM_001331048
RefSeq (protein)	NP_001186209 NP_005320 NP_619515	NP_001317977 NP_032243
Location (UCSC)	n/a	Chr 8: 107.6 – 107.61 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Hijaluronanska sintaza 3 je enzim koji je kod ljudi kodiran genom HAS3.^[4][5][6]

Reference

1. GRCm38: Ensembl release 89: ENSMUSG00000031910 - Ensembl, May 2017
2. „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
3. „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (јул 1997). „Chromosomal localization of the human and mouse hyaluronan synthase genes”. Genomics. 41 (3): 493—7. PMID 9169154. doi:10.1006/geno.1997.4696. CS1 одржавање: Формат датума (веза)
5. Spicer AP, Olson JS, McDonald JA (мај 1997). „Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase”. J Biol Chem. 272 (14): 8957—61. PMID 9083017. doi:10.1074/jbc.272.14.8957 . CS1 одржавање: Формат датума (веза)
6. „Entrez Gene: HAS3 hyaluronan synthase 3”. 

Literatura

• Jacobson A, Brinck J, Briskin MJ, et al. (2000). „Expression of human hyaluronan synthases in response to external stimuli.”. Biochem. J. 348. Pt 1 (1): 29—35. PMC 1221032 . PMID 10794710. doi:10.1042/0264-6021:3480029. 
• Simpson MA, Reiland J, Burger SR, et al. (2001). „Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells.”. J. Biol. Chem. 276 (21): 17949—57. PMID 11278609. doi:10.1074/jbc.M010064200 . 
• Kuroda K, Utani A, Hamasaki Y, Shinkai H (2001). „Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts.”. J. Dermatol. Sci. 26 (2): 156—60. PMID 11378333. doi:10.1016/S0923-1811(00)00155-9. 
• Liu N, Gao F, Han Z, et al. (2001). „Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.”. Cancer Res. 61 (13): 5207—14. PMID 11431361. 
• Simpson MA, Wilson CM, Furcht LT, et al. (2002). „Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.”. J. Biol. Chem. 277 (12): 10050—7. PMID 11790779. doi:10.1074/jbc.M110069200 . 
• Sayo T, Sugiyama Y, Takahashi Y, et al. (2002). „Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes.”. J. Invest. Dermatol. 118 (1): 43—8. PMID 11851874. doi:10.1046/j.0022-202x.2001.01613.x . 
• Chagnon P, Michaud J, Mitchell G, et al. (2003). „A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.”. Am. J. Hum. Genet. 71 (6): 1443—9. PMC 378590 . PMID 12417987. doi:10.1086/344580. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 . 
• Bullard KM, Kim HR, Wheeler MA, et al. (2004). „Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth.”. Int. J. Cancer. 107 (5): 739—46. PMID 14566823. S2CID 24405794. doi:10.1002/ijc.11475 . 
• Suzuki K, Yamamoto T, Usui T, et al. (2004). „Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.”. Jpn. J. Ophthalmol. 47 (6): 557—64. PMID 14636845. doi:10.1016/j.jjo.2003.09.001. 
• Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). „Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells.”. Biochim. Biophys. Acta. 1760 (6): 890—5. PMID 16564133. doi:10.1016/j.bbagen.2006.02.002. 
• Campo GM, Avenoso A, Campo S, et al. (2007). „TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.”. Mol. Cell. Biochem. 292 (1–2): 169—78. PMID 16786194. S2CID 37598580. doi:10.1007/s11010-006-9230-7.