HTR3A

5-hidroksitriptaminski (serotoninski) receptor 3A, jonotropni
Identifikatori
Simboli HTR3A; 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3
Vanjski ID OMIM: 182139 MGI: 96282 HomoloGene: 671 IUPHAR: 5-HT3A GeneCards: HTR3A Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3359 15561
Ensembl ENSG00000166736 ENSMUSG00000032269
UniProt P46098 P23979
RefSeq (mRNA) NM_000869 NM_001099644
RefSeq (protein) NP_000860 NP_001093114
Lokacija (UCSC) Chr 11:
113.85 - 113.86 Mb		 Chr 9:
48.9 - 48.91 Mb
PubMed pretraga [1] [2]

5-hidroksitriptaminski receptor 3A je protein koji je kod čoveka kodiran HTR3A genom.[1][2]

Produkt ovog gena pripada receptorskoj familiji ligandom konstrolisanih jonskih kanala. Ovaj gen kodira podjedinicu A tipa 3 receptora za 5-hidroksitriptamin (serotonin), biogeni hormon koji deluje kao neurotransmiter, hormon, i mitogen. Ovaj receptor uzrokujue brze, depolaricione response u neuronima nakon aktivacije. Heteromerna kombinacija A i B podjedinica je neophodna da bi se formirao potpuno funkcionalni receptor. Homomerni receptor bilo koja podjednice imaju veoma nisku provodnost i malu amplitudu responsa. Alternativno splajsovane transkriptne varijante koje kodiraju različite izoforme su poznate.[3]

Vidi još

[уреди | уреди извор]

Reference

[уреди | уреди извор]
  1. ^ Weiss B, Mertz A, Schrock E, Koenen M, Rappold G (1996). „Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2”. Genomics. 29 (1): 304—5. PMID 8530095. doi:10.1006/geno.1995.1254. 
  2. ^ Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (2003). „A cytoplasmic region determines single-channel conductance in 5-HT3 receptors”. Nature. 424 (6946): 321—4. PMID 12867984. doi:10.1038/nature01788. 
  3. ^ „Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A”. 

Literatura

[уреди | уреди извор]
  • Miyake A, Mochizuki S, Takemoto Y, Akuzawa S (1995). „Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.”. Mol. Pharmacol. 48 (3): 407—16. PMID 7565620. 
  • Uetz P; Abdelatty F; Villarroel A; et al. (1994). „Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11.”. FEBS Lett. 339 (3): 302—6. PMID 8112471. doi:10.1016/0014-5793(94)80435-4. 
  • Belelli D; Balcarek JM; Hope AG; et al. (1996). „Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.”. Mol. Pharmacol. 48 (6): 1054—62. PMID 8848005. 
  • Brüss M, Göthert M, Hayer M, Bönisch H (1999). „Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs.”. Ann. N. Y. Acad. Sci. 861: 234—5. PMID 9928262. doi:10.1111/j.1749-6632.1998.tb10196.x. 
  • Davies PA; Pistis M; Hanna MC; et al. (1999). „The 5-HT3B subunit is a major determinant of serotonin-receptor function.”. Nature. 397 (6717): 359—63. PMID 9950429. doi:10.1038/16941. 
  • Brüss M, Eucker T, Göthert M, Bönisch H (2000). „Exon-intron organization of the human 5-HT3A receptor gene.”. Neuropharmacology. 39 (2): 308—15. PMID 10670426. doi:10.1016/S0028-3908(99)00116-1. 
  • Marazziti D; Betti L; Giannaccini G; et al. (2002). „Distribution of [3H]GR65630 binding in human brain postmortem.”. Neurochem. Res. 26 (3): 187—90. PMID 11495540. doi:10.1023/A:1010939530412. 
  • Spier AD, Lummis SC (2003). „Immunological characterization of 5-HT3 receptor transmembrane topology.”. J. Mol. Neurosci. 18 (3): 169—78. PMID 12059035. doi:10.1385/JMN:18:3:169. 
  • Boyd GW; Low P; Dunlop JI; et al. (2002). „Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins.”. Mol. Cell. Neurosci. 21 (1): 38—50. PMID 12359150. doi:10.1006/mcne.2002.1160. 
  • Hapfelmeier G; Haseneder R; Lampadius K; et al. (2003). „Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics.”. Neurosci. Lett. 335 (1): 44—8. PMID 12457738. doi:10.1016/S0304-3940(02)01156-4. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Pick H; Preuss AK; Mayer M; et al. (2003). „Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells”. Biochemistry. 42 (4): 877—84. PMID 12549905. doi:10.1021/bi026576d. 
  • Choi S; Lee JH; Oh S; et al. (2003). „Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes”. Mol. Cells. 15 (1): 108—13. PMID 12661769. 
  • Boyd GW; Doward AI; Kirkness EF; et al. (2003). „Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal”. J. Biol. Chem. 278 (30): 27681—7. PMID 12750374. doi:10.1074/jbc.M304938200. 
  • Sun H; Hu XQ; Moradel EM; et al. (2003). „Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C”. J. Biol. Chem. 278 (36): 34150—7. PMID 12791692. doi:10.1074/jbc.M303584200. 
  • Maksay G, Bikádi Z, Simonyi M (2004). „Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models”. J. Recept. Signal Transduct. Res. 23 (2–3): 255—70. PMID 14626451. doi:10.1081/RRS-120025568. 
  • Kaiser R; Tremblay PB; Sezer O; et al. (2004). „Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists”. Pharmacogenetics. 14 (5): 271—8. PMID 15115912. doi:10.1097/00008571-200405000-00001. 
  • Panicker S; Cruz H; Arrabit C; et al. (2004). „Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor”. J. Biol. Chem. 279 (27): 28149—58. PMID 15131114. doi:10.1074/jbc.M403545200. 

Spoljašnje veze

[уреди | уреди извор]