Hipofizni adenilat ciklazno aktivirajući peptid

Hipofizni adenilat ciklazno aktivirajući peptid
Hipofizni adenilat ciklazno aktivirajući peptid
	PDB prikaz baziran na 2d2p.
Dostupne strukture
	1GEA, 2D2P, 2JOD
Identifikatori
Simboli	ADCYAP1; PACAP
Vanjski ID	OMIM: 102980 MGI: 105094 HomoloGene: 869 GeneCards: ADCYAP1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptorskog signalnog proteina; • receptorskog vezivanje; • neuropeptidna hormonska aktivnost; • aktivnost hipofizno adenilat ciklazno aktivirajućeg peptida;
Celularna komponenta	• ekstracelularni region; • rastvorna frakcija;
Biološki proces	• signalni put tirozinsko kinaznog transmembranskog receptora; • aktivacija adenilat ciklaze; • međućelijska signalizacija; • trudnoća;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	116
Ensembl	ENSG00000141433
UniProt	P18509
RefSeq (mRNA)	NM_001099733.1
RefSeq (protein)	NP_001093203.1
Lokacija (UCSC)	Chr 18:; 0.9 - 0.91 Mb
PubMed pretraga	[1]

Hipofizni adenilat ciklazno aktivirajući peptid (PACAP) je protein koji je kod ljudi kodiran ADCYAP1 genom.^[1]^[2] PACAP je sličan sa vazoaktivnim intestinalnim peptidom. Jedan od njegovih efekata je stimulacija enterohromafinu sličnih ćelija. On se vezuje za receptor vazoaktivnog intestinalnog peptida.

Funkcija

Posredstvom hipofiznog adenilat ciklazno aktivirajućeg polipeptidnog receptor tipa I, ovaj polipeptid stimuliše adenilat ciklazu i naknadno povišava nivoe cAMP u ciljnim ćelijama. Adenilat ciklazno aktivirajući peptid 1 nije samo hipofiziotropni hormon, nego takođe funkcioniše kao neurotransmiter i neuromodulator. Osim toga on učestvuje u parakrinoj i autokrinoj regulacije pojedinih tipova ćelija. Ovaj gen se sastoji of pet eksona. Eksoni 1 i 2 kodiraju 5' UTR i signalni peptid, respektivno; ekson 4 kodira peptid srodan adenilat ciklazno aktivirajućem polipeptidu; i ekson 5 kodira maturisani peptid i 3' UTR. Ovaj gen kodira tri različita peptida, uključujući dva izotipa: kratku i dugačku formu.^[2]

Interakcije

Hipofizni adenilat ciklazno aktivirajući peptid formira interakcije sa sektretinskim receptorom.^[3]

Reference

^ Hosoya M; Kimura C; Ogi K; Ohkubo S; Miyamoto Y; Kugoh H; Shimizu M; Onda H; Oshimura M; Arimura A; et al. (1992). „Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene”. Biochim Biophys Acta. 1129 (2): 199—206. PMID 1730060.
^ ^а ^б „Entrez Gene: ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)”.
^ Felley, C P; Qian J M; et al. (1992). „Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release”. Am. J. Physiol. UNITED STATES. 263 (6 Pt 1): G901—7. ISSN 0002-9513. PMID 1335692.

Literatura

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Spoljašnje veze

Pituitary+adenylate+cyclase-activating+polypeptide на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid1730060-1] Hosoya M; Kimura C; Ogi K; Ohkubo S; Miyamoto Y; Kugoh H; Shimizu M; Onda H; Oshimura M; Arimura A; et al. (1992). „Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene”. Biochim Biophys Acta. 1129 (2): 199—206. PMID 1730060.

[entrez-2] а ^б „Entrez Gene: ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)”.

[pmid1335692-3] Felley, C P; Qian J M; et al. (1992). „Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release”. Am. J. Physiol. UNITED STATES. 263 (6 Pt 1): G901—7. ISSN 0002-9513. PMID 1335692.

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