Jararhagin
| Jararhagin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.73 | ||||||||
| CAS broj | 160477-79-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Jararhagin (EC 3.4.24.73, HF2-proteinaza, JF1) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza -His10-Leu-, -Ala14-Leu-, -Tyr16-Leu- i -Phe24-Phe- veza u insulinskom B lancu
Ova hemoragička endopeptidaza je prisutna u venumu zmije Bothrops jararaca.
Reference
[уреди | уреди извор]- ^ Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). „Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca”. Ур.: Ohsaka, A., Hayashi, K. and Sawai, Y. Animal, Plant and Microbial Toxins. New York: Plenum Press. стр. 111—121.
- ^ Assakura, M.T., Reichl, A.P. and Mandelbaum, F.R. (1986). „Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)”. Toxicon. 24: 943—946. PMID 3810664.
- ^ Paine, M.J.I., Desmond, H.P., Theakston, R.D.G. and Crampton, J.M. (1992). „Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family”. J. Biol. Chem. 267: 22869—22876. PMID 1385408.
Литература
[уреди | уреди извор]- Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). „Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca”. Ур.: Ohsaka, A., Hayashi, K. and Sawai, Y. Animal, Plant and Microbial Toxins. New York: Plenum Press. стр. 111—121.
Spoljašnje veze
[уреди | уреди извор]- Jararhagin на US National Library of Medicine Medical Subject Headings (MeSH)
