Faktor licenciranja DNK replikacije MCM4 je protein koji je kod ljudi kodiran MCM4genom.[4]
Protein kodiran ovim genom je jedan od visoko konzerviranjih proteina održavanja mini-hromozoma (MCM) koji učestvuju u inicijaciji replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prereplikacionog kompleksa (pre-RC). On učestuje u formiranju replikacionih viljuški i regrutaciji drugih srodnih proteina replikacije DNK. Ovaj protein formira kompleks sa MCM2, 6, i 7, i pokazano je da reguliše helikaznu aktivnost kompleksa. Smatra se da deluje kao enzim odvijanja DNK. Fosforilacija ovog proteina posredstvom CDC2 kinaze redukuje DNK helikaznu aktivnost i hromatinsko vezivanje MCM kompleksa. Ovaj gen je mapiran na region hromozoma 8 pored PRKDC/DNA-PK, DNK-aktivirane proteinske kinaze koja učestvuje u popravci prekida dvolančane DNK. Alternativno splajsovane transkriptne varijante kodiraju isti protein.[5]
^„Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^„Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
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^ абYou, Zhiying; Ishimi Yukio; Masai Hisao; Hanaoka Fumio (2002). „Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex”. J. Biol. Chem. United States. 277 (45): 42471—9. ISSN0021-9258. PMID12207017. doi:10.1074/jbc.M205769200.
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Ishimi Y; Ichinose S; Omori A; et al. (1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. 271 (39): 24115—22. PMID8798650. doi:10.1074/jbc.271.39.24115.
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Ishimi Y, Komamura-Kohno Y (2001). „Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity”. J. Biol. Chem. 276 (37): 34428—33. PMID11454864. doi:10.1074/jbc.M104480200.
You Z, Ishimi Y, Masai H, Hanaoka F (2003). „Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex”. J. Biol. Chem. 277 (45): 42471—9. PMID12207017. doi:10.1074/jbc.M205769200.
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