Faktor licenciranja DNK replikacije MCM7 je protein koji je kod ljudi kodiran MCM7genom.[4]
Protein kodiran ovim genom je jedan od visoko konzerviranih proteina mini-hromozomskog održavanja (MCM) koji su esencijalni za inicijaciju replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prireplikacionog kompleksa (pre-RC) i može da učestuje u formiranju replikacionih viljuški i regrutovanju drugih proteina vezanih za DNK replikaciju. MCM kompleks se sastoji od ovog proteina i MCM2, dok 4 i 6 proteini poseduju DNK helikaznu aktivnost, i mogu da deluju kao enzimi DNK odmotavanja. Utvrđeno je da je ciklin D1-zavisna kinaza, CDK4, asocirana sa ovim proteinom, i da može da reguliše vezivanje ovog proteina sa proteinom supresije tumora RB1/RB. Poznate su alternativno splajsovane transkriptne varijante koje kodiraju distinktne izoforme.[5]
^„Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^„Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nakatsuru S, Sudo K, Nakamura Y (1995). „Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication”. Cytogenet Cell Genet. 68 (3-4): 226—30. PMID7842741. doi:10.1159/000133918.
^ абвгдђежзијклKneissl M, Pütter V, Szalay AA, Grummt F (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. 327 (1): 111—28. PMID12614612. doi:10.1016/s0022-2836(03)00079-2.
^Kukimoto I, Igaki H, Kanda T (1999). „Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha”. Eur. J. Biochem. 265 (3): 936—43. PMID10518787. doi:10.1046/j.1432-1327.1999.00791.x.
^ абFujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation”. J. Biol. Chem. 274 (36): 25927—32. PMID10464337. doi:10.1074/jbc.274.36.25927.
^ абвгдFujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. 272 (16): 10928—35. PMID9099751. doi:10.1074/jbc.272.16.10928.
^ абвYabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (2003). „Mammalian Mcm2/4/6/7 complex forms a toroidal structure”. Genes Cells. 8 (5): 413—21. PMID12694531. doi:10.1046/j.1365-2443.2003.00645.x.
^ абвYou Z, Ishimi Y, Masai H, Hanaoka F (2002). „Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex”. J. Biol. Chem. 277 (45): 42471—9. PMID12207017. doi:10.1074/jbc.M205769200.
^Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (2002). „Nuclear organization of DNA replication initiation proteins in mammalian cells”. J. Biol. Chem. 277 (12): 10354—61. PMID11779870. doi:10.1074/jbc.M111398200.
^Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. 271 (39): 24115—22. PMID8798650. doi:10.1074/jbc.271.39.24115.
^Wang Y, Xu F, Hall FL (2000). „The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor”. FEBS Lett. 484 (1): 17—21. PMID11056214. doi:10.1016/s0014-5793(00)02117-7.
^Kühne C, Banks L (1998). „E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box”. J. Biol. Chem. 273 (51): 34302—9. PMID9852095. doi:10.1074/jbc.273.51.34302.
Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (1991). „Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle.”. Biochem. Biophys. Res. Commun. 177 (1): 395—400. PMID1710453. doi:10.1016/0006-291X(91)91996-P.
Musahl C, Schulte D, Burkhart R, Knippers R (1995). „A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins.”. Eur. J. Biochem. 230 (3): 1096—101. PMID7601140. doi:10.1111/j.1432-1033.1995.tb20660.x.
Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (1994). „The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21.”. Cytogenet. Cell Genet. 65 (4): 276—7. PMID8258304. doi:10.1159/000133647.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107—13. PMID8619474. doi:10.1006/abio.1996.0138.
Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1996). „hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase.”. J. Biol. Chem. 271 (8): 4349—54. PMID8626784. doi:10.1074/jbc.271.8.4349.
Schulte D, Richter A, Burkhart R, Musahl C, Knippers R (1996). „Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins.”. Eur. J. Biochem. 235 (1-2): 144—51. PMID8631321. doi:10.1111/j.1432-1033.1996.00144.x.
Kiyono T, Fujita M, Hayashi Y, Ishibashi M (1996). „Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family.”. Biochim. Biophys. Acta. 1307 (1): 31—4. PMID8652665. doi:10.1016/0167-4781(96)00057-7.
Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). „Binding of human minichromosome maintenance proteins with histone H3.”. J. Biol. Chem. 271 (39): 24115—22. PMID8798650. doi:10.1074/jbc.271.39.24115.
Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.”. J. Biol. Chem. 272 (16): 10928—35. PMID9099751. doi:10.1074/jbc.272.16.10928.
Ishimi Y (1997). „A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.”. J. Biol. Chem. 272 (39): 24508—13. PMID9305914. doi:10.1074/jbc.272.39.24508.
Suzuki S, Adachi A, Hiraiwa A, Ohashi M, Ishibashi M, Kiyono T (1998). „Cloning and characterization of human MCM7 promoter.”. Gene. 216 (1): 85—91. PMID9714754. doi:10.1016/S0378-1119(98)00323-0.
Kühne C, Banks L (1999). „E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box.”. J. Biol. Chem. 273 (51): 34302—9. PMID9852095. doi:10.1074/jbc.273.51.34302.
Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.”. J. Biol. Chem. 274 (36): 25927—32. PMID10464337. doi:10.1074/jbc.274.36.25927.
Freeman A, Morris LS, Mills AD, Stoeber K, Laskey RA, Williams GH, Coleman N (1999). „Minichromosome maintenance proteins as biological markers of dysplasia and malignancy.”. Clin. Cancer Res. 5 (8): 2121—32. PMID10473096.
Kukimoto I, Igaki H, Kanda T (1999). „Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.”. Eur. J. Biochem. 265 (3): 936—43. PMID10518787. doi:10.1046/j.1432-1327.1999.00791.x.