OPN1LW

Opsin 1, senzitivan na dugačke talasne dužine
Opsin 1, senzitivan na dugačke talasne dužine
Identifikatori
Simboli	OPN1LW; CBP; CBBM; RCP
Vanjski ID	OMIM: 303900 MGI: 1097692 HomoloGene: 68064 GeneCards: OPN1LW Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • fotoreceptorska aktivnost;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • vizuelna percepcija; • fototransdukcija; • protein-hromofor veza; • respons na stimulus;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	5956
Ensembl	ENSG00000102076
UniProt	P04000
RefSeq (mRNA)	NM_020061
RefSeq (protein)	NP_064445
Lokacija (UCSC)	Chr X:; 153.06 - 153.08 Mb
PubMed pretraga	[1]

OPN1LW, crveno-senzitivni opsin, je protein koji je kod ljudi kodiran OPN1LW genom.^[1]

Ovaj gen kodira pigment iz familije opsina koji apsorbuje svetlost. On se naziva crveni fotopigment kupastih ćelija, ili opsin senzitivan na dugačke talasne dužine. Opsini su grupa G-protein spregnutih receptora sa sedam transmembranskih domena, ekstracelularnim N-terminusnim domenom, i citosolnim C-terminusom. Ovaj gen i opsinski geni srednjih-talasnih dužina su grupisani na X hromozomu. Česte neravnomerne rekombinacije i konverzije gena se mogu javiti između tih sekvenci. X hromozomi mogu da imaju spajanja gena opsina srednje i duge talasne dužine, ili višestruke kopije tih gena. Defekti ovog gena su uzrok parcijalne slepoće za boje.^[1]

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Opsin

Literatura

^ ^а ^б „Entrez Gene: OPN1LW opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)”.

Dodatna literatura

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Voegel JJ; Heine MJ; Tini M; et al. (1998). „The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.”. EMBO J. 17 (2): 507—19. PMC 1170401 . PMID 9430642. doi:10.1093/emboj/17.2.507.
Zhao Z, Hewett-Emmett D, Li WH (1998). „Frequent gene conversion between human red and green opsin genes.”. J. Mol. Evol. 46 (4): 494—6. PMID 9541545. doi:10.1007/PL00013147.
Nakayama TA, Zhang W, Cowan A, Kung M (1999). „Mutagenesis studies of human red opsin: trp-281 is essential for proper folding and protein-retinal interactions.”. Biochemistry. 37 (50): 17487—94. PMID 9860863. doi:10.1021/bi982077u.
John SK, Smith JE, Aguirre GD, Milam AH (2000). „Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa.”. Mol. Vis. 6: 204—15. PMID 11063754.
Ueyama H; Kuwayama S; Imai H; et al. (2002). „Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies.”. Biochem. Biophys. Res. Commun. 294 (2): 205—9. PMID 12051694. doi:10.1016/S0006-291X(02)00458-8.
Fitzgerald KA; Rowe DC; Barnes BJ; et al. (2003). „LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.”. J. Exp. Med. 198 (7): 1043—55. PMC 2194210 . PMID 14517278. doi:10.1084/jem.20031023.
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[entrez-1] а ^б „Entrez Gene: OPN1LW opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)”.

[1]