Proproteinska konvertaza 2
| Proproteinska konvertaza 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.94 | ||||||||
| CAS broj | 130960-94-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| Ontologija gena | AmiGO / EGO | ||||||||
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Proproteinska konvertaza 2 (PC2), (prohormonska konvertaza 2, neuroendokrinska konvertaza 2 (NEC2)) je serinska proteaza i proproteinska konvertaza PC2. Poput proproteinske konvertaze 1 (PC1), to je enzim odgovoran za prvi korak u maturaciji mnogih neuroendokrinih peptida iz njihovih prekurzora, kao što je konverzija proinsulina u insulinske međuprodukte. Da bi se generisala bioaktivna forma insulina (i mnogih drugih peptida), sekundarni korak koji se sastoji od uklanjanja C-terminalnih baznih ostataka je neophodan. Taj korak je posredovan karboksipeptidazama E i/ili D. PC2 ima samo manju ulogu u prvom koraku biosinteze insulina, dok je njegova uloga značajnija u prvom stepenu biosinteze glukagona u poređenju sa PC1. PC2 se vezuje za neuroendokrini protein 7B2, i ako taj protein nije prisutan, proPC2 ne može da postane enzimatski aktivan. 7B2 takođe inhibira PC2 dejstvo dok se 7B2 ne ispreseca u manje neaktivne forme. Stoga je 7B2 aktivator i inhibitor PC2 enzima.
Kod čoveka, proproteinska konvertaza 2 je kodirana PCSK2 genom.[1] On je srodan sa bakterijskim enzimom subtilisinom. Sve zajedno postoji devet različitih subtilisinu-sličnih gena kod sisara: furin, PACE4, PC4, PC5/6, PC7/8, PCSK9 i SKI1/S1P.
Reference
[уреди | уреди извор]- ^ Seidah NG, Mattei MG, Gaspar L, Benjannet S, Mbikay M, Chrétien M (1991). „Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region)”. Genomics. 11 (1): 103—7. PMID 1765368. doi:10.1016/0888-7543(91)90106-O.
Literatura
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- {{cite journal |vauthors=Zhu X, Lindberg I |title=7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity. |journal=J Cell Biol. |volume=129 |issue= 6 |pages= 1641–50 |year= 1995 |pmid= 7790360| pmc=2291188|
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Spoljašnje veze
[уреди | уреди извор]- Proprotein+convertase+2 на US National Library of Medicine Medical Subject Headings (MeSH)
