Receptor insulinu sličnog faktora rasta 1

Receptor insulinu sličnog faktora rasta 1‎‎
Prva tri domena receptora insulinu sličnog faktora rasta 1‎‎. PDB prikaz baziran na 1igr​.
Dostupne strukture
1IGR​, 1JQH​, 1K3A​, 1M7N​, 1P4O​, 2OJ9​, 2ZM3​, 3D94​, 3F5P​, 3I81​, 3LVP​, 3LW0​, 3NW5​, 3NW6​, 3NW7​, 3O23​, 3QQU​
Identifikatori
Simboli	IGF1R; CD221; IGFIR; IGFR; JTK13
Vanjski ID	OMIM: 147370 MGI: 96433 HomoloGene: 30997 GeneCards: IGF1R Gene
EC broj	2.7.10.1
Ontologija gena Molekularna funkcija • aktivnost proteinske tirozinske kinaze • aktivnost receptora insulinu sličnog faktora rasta • vezivanje insulinskog receptora Celularna komponenta • integralno sa ćelijskom membranom • kaveola • membrana Biološki proces • imunski respons • prenos signala • aksonogeneza
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	3480	16001
Ensembl	ENSG00000140443	ENSMUSG00000005533
UniProt	P08069	Q60751
RefSeq (mRNA)	NM_000875.3	NM_010513.2
RefSeq (protein)	NP_000866.1	NP_034643.2
Lokacija (UCSC)	Chr 15: 99.19 - 99.51 Mb	Chr 7: 67.95 - 68.23 Mb
PubMed pretraga	[1]	[2]

Receptor insulinu sličnog faktora rasta 1 je protein koji je prisutan na površini ljudskih ćelija. On je transmembranski receptor koji se aktivira IGF-1 hormonom (insulinu sličan faktor rasta 1) i srodnim hormonom IGF-2. On pripada velikoj klasi tirozinsko kinaznih receptora. Ovaj receptor posreduje dejstvo IGF-1, koji je polipeptidni proteinski hormon sličan insulinu. IGF-1 utiče na razviće i nastavlja da vrši anaboličko dejstvo kod odraslih. On može da indukuje hipertroifju skeletalnih mišića i drugih ciljnih tkiva. Miševi bez IGF-1 receptora umiru u kasnijem periodu razvića, i manifestuju dramatičnu redukcu telesne mase, što potvrđuje jak uticaj ovog receptora. Miševi sa samo jednom funkcionalnom kopijom IGF1R su normalni, ali ispoljavaju ~15% umanjenje telesne mase.

Interakcije

Receptor insulinu sličnog faktora rasta 1 formira interakcije sa SOCS3,^[1] PTPN11,^[2][3] SOCS2,^[4] GRB10,^[5][6][7][8] PIK3R3,^[9] C-src tirosinska kinaza,^[10] EHD1,^[11] Cbl genom,^[12] RAS p21 proteinskim aktivatorom 1,^[3] IRS1,^[2][6][13] ARHGEF12,^[14] YWHAE,^[15] Mdm2,^[12] SHC1^[6][13][16] i NEDD4.^[5][12]

Regulacija

Postoji evidencija da je IGF1R negativno regulisan dejstvom mikroRNK miR-7.^[17]

Vidi još

• Insulinski receptor
• Linzitinib, inhibitor IGF-1 u kliničkim ispitivanje za tretman kancera

References

1. Dey, B R; Furlanetto R W; Nissley P (2000). „Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor”. Biochem. Biophys. Res. Commun. UNITED STATES. 278 (1): 38—43. ISSN 0006-291X. PMID 11071852. doi:10.1006/bbrc.2000.3762. 
2. Mañes, S; Mira E; et al. (1999). „Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility”. Mol. Cell. Biol. UNITED STATES. 19 (4): 3125—35. ISSN 0270-7306. PMC 84106 . PMID 10082579.  Недостаје |last2= у Authors list (помоћ)
3. Seely, B L; Reichart D R; et al. (1995). „Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein”. J. Biol. Chem. UNITED STATES. 270 (32): 19151—7. ISSN 0021-9258. PMID 7642582. doi:10.1074/jbc.270.32.19151.  Недостаје |last2= у Authors list (помоћ)
4. Dey, B R; Spence S L; et al. (1998). „Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor”. J. Biol. Chem. UNITED STATES. 273 (37): 24095—101. ISSN 0021-9258. PMID 9727029. doi:10.1074/jbc.273.37.24095. 
5. Vecchione, Andrea; Marchese Adriano; et al. (2003). „The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor”. Mol. Cell. Biol. United States. 23 (9): 3363—72. ISSN 0270-7306. PMC 153198 . PMID 12697834. doi:10.1128/MCB.23.9.3363-3372.2003. 
6. Dey, B R; Frick K; et al. (1996). „Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10”. Mol. Endocrinol. UNITED STATES. 10 (6): 631—41. ISSN 0888-8809. PMID 8776723. doi:10.1210/me.10.6.631. 
7. He, W; Rose D W; et al. (1998). „Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains”. J. Biol. Chem. UNITED STATES. 273 (12): 6860—7. ISSN 0021-9258. PMID 9506989. doi:10.1074/jbc.273.12.6860. 
8. Morrione, A; Valentinis B; et al. (1996). „Grb10: A new substrate of the insulin-like growth factor I receptor”. Cancer Res. UNITED STATES. 56 (14): 3165—7. ISSN 0008-5472. PMID 8764099. 
9. Mothe, I; Delahaye L; et al. (1997). „Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins”. Mol. Endocrinol. UNITED STATES. 11 (13): 1911—23. ISSN 0888-8809. PMID 9415396. doi:10.1210/me.11.13.1911. 
10. Arbet-Engels, C; Tartare-Deckert S; Eckhart W (1999). „C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor”. J. Biol. Chem. UNITED STATES. 274 (9): 5422—8. ISSN 0021-9258. PMID 10026153. doi:10.1074/jbc.274.9.5422. 
11. Rotem-Yehudar, R; Galperin E; Horowitz M (2001). „Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29”. J. Biol. Chem. United States. 276 (35): 33054—60. ISSN 0021-9258. PMID 11423532. doi:10.1074/jbc.M009913200. 
12. Sehat, Bita; Andersson Sandra; et al. (2008). „Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis”. Cancer Res. United States. 68 (14): 5669—77. PMID 18632619. doi:10.1158/0008-5472.CAN-07-6364.  Недостаје |last2= у Authors list (помоћ)
13. Tartare-Deckert, S; Sawka-Verhelle D; et al. (1995). „Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system”. J. Biol. Chem. UNITED STATES. 270 (40): 23456—60. ISSN 0021-9258. PMID 7559507. doi:10.1074/jbc.270.40.23456. 
14. Taya, S; Inagaki N; et al. (2001). „Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF”. J. Cell Biol. United States. 155 (5): 809—20. ISSN 0021-9525. PMC 2150867 . PMID 11724822. doi:10.1083/jcb.200106139. 
15. Craparo, A; Freund R; Gustafson T A (1997). „14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner”. J. Biol. Chem. UNITED STATES. 272 (17): 11663—9. ISSN 0021-9258. PMID 9111084. doi:10.1074/jbc.272.17.11663. 
16. Santen, R J; Song R X; et al. (2005). „Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity”. Endocr. Relat. Cancer. 12. England. Suppl 1 (Supplement_1): S61—73. ISSN 1351-0088. PMID 16113100. doi:10.1677/erc.1.01018. 
17. Jiang, Lu; Liu, Xiqiang; Chen, Zujian; Jin, Yi; Heidbreder, Caroline E.; Kolokythas, Antonia; Wang, Anxun; Dai, Yang; Zhou, Xiaofeng (2010). „MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells”. Biochemical Journal. 432 (1): 199—205. PMID 20819078. doi:10.1042/BJ20100859. 

Literatura

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• Butler AA; Yakar S; Gewolb IH; et al. (1999). „Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology.”. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 121 (1): 19—26. PMID 9972281. doi:10.1016/S0305-0491(98)10106-2. 
• Zhang X, Yee D (2001). „Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.”. Breast Cancer Res. 2 (3): 170—5. PMC 138771 . PMID 11250706. doi:10.1186/bcr50. 
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Spoljašnje veze

• IGF-1+Receptor на US National Library of Medicine Medical Subject Headings (MeSH)