Terizidon

Terizidon

Klinički podaci
Drugs.com	Monografija
Identifikatori
CAS broj	25683-71-0^Y
ATC kod	J04AK03 (WHO)
PubChem	CID 65720
ChemSpider	59144^Y
UNII	1199LEX5N8^Y
KEGG	D07247^Y
Sinonimi	4-[({4-[N-(3-oxo-1,2-oxazolidin-4-yl)carboximidoyl]phenyl}methylidene)amino]-1,2-oxazolidin-3-one
Hemijski podaci
Formula	C14H14N4O4
Molarna masa	302,285
SMILES OC1=NOCC1\N=C\c2ccc(\C=N\C3CON=C3O)cc2
InChI InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+^Y Key:ODKYYBOHSVLGNU-IAGONARPSA-N^Y

Terizidon je organsko jedinjenje, koje sadrži 14 atoma ugljenika i ima molekulsku masu od 302,285 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	8
Broj donora vodonika	2
Broj rotacionih veza	4
Particioni koeficijent[1] (ALogP)	1,0
Rastvorljivost[2] (logS, log(mol/L))	-3,7
Polarna površina[3] (PSA, Å^2)	108,4

Reference

1. Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
2. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
3. Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

• Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803. 
• Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799. 

Spoljašnje veze

• Terizidone

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