UGT2B4

UGT2B4
Identifikatori
Alijasi	UGT2B4
Spoljašnji ID	OMIM: 600067 MGI: 1919023 HomoloGene: 130717 GeneCards: UGT2B4
Genska lokacija (miš)
Hr.	Chromosome 5 (mouse)
Kraj	87,074,389 bp
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• glycosyltransferase activity; • transferase activity; • glucuronosyltransferase activity; • retinoic acid binding; • hexosyltransferase activity; • UDP-glycosyltransferase activity;
Cellular component	• саставни део мембране; • organelle membrane; • endoplasmic reticulum membrane; • intracellular membrane-bounded organelle; • ендоплазматични ретикулум; • мембрана;
Biological process	• Glukuronidacija; • метаболизам;
	Sources:Amigo / QuickGO
Ortolozi
	7363
	71773
	ENSG00000156096
	ENSMUSG00000035836
	P06133
	Q8R084
	NM_001297615; NM_001297616; NM_021139
	NM_152811
	NP_001284544; NP_001284545; NP_066962
	NP_690024
	Wikidata
View/Edit Human	View/Edit Mouse

UDP glukuronoziltransferaza 2 familija, polipeptid B4, takođe poznata kao UGT2B4, je enzim koji je kod ljudi kodiran genom UGT2B4.^[4]^[5]^[6]

Function

UGT2B4 je uglavnom uključen u glukuronidaciju hiodezoksiholne kiseline, žučne kiseline i katehol-estrogena, kao što su 17-epiestriol i 4-hidroksi-estron.^[7]

Izražavanje enzima UGT2B4 pojačava farnezoidni X receptor (FXR), nuklearni receptor koji se aktivira žučnim kiselinama.^[8] Ove iste žučne kiseline su supstrati za enzim UGT2B4. Otuda povećanje regulacije UGT2B4 aktiviranim FXR-om obezbeđuje mehanizam za detekciju, konjugaciju i naknadnu eliminaciju toksičnih žučnih kiselina.

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000035836 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Entrez Gene: UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4”.
^ Jackson MR, McCarthy LR, Harding D, Wilson S, Coughtrie MW, Burchell B (март 1987). „Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA”. Biochem. J. 242 (2): 581—8. PMC 1147744 . PMID 3109396. doi:10.1042/bj2420581.
^ Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (септембар 1994). „Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13”. Genomics. 23 (2): 496—9. PMID 7835904. doi:10.1006/geno.1994.1531.
^ Barre L, Fournel-Gigleux S, Finel M, Netter P, Magdalou J, Ouzzine M (март 2007). „Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33”. FEBS J. 274 (5): 1256—64. PMID 17263731. S2CID 27151203. doi:10.1111/j.1742-4658.2007.05670.x .
^ Barbier O, Torra IP, Sirvent A, Claudel T, Blanquart C, Duran-Sandoval D, Kuipers F, Kosykh V, Fruchart JC, Staels B (јун 2003). „FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity”. Gastroenterology. 124 (7): 1926—40. PMID 12806625. doi:10.1016/S0016-5085(03)00388-3.

Literatura

Mackenzie PI, Owens IS, Burchell B, et al. (1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001.
Kadlubar FF, Miller JA, Miller EC (1977). „Hepatic microsomal N-glucuronidation and nucleic acid binding of N-hydroxy arylamines in relation to urinary bladder carcinogenesis”. Cancer Res. 37 (3): 805—14. PMID 13929.
Ritter JK, Chen F, Sheen YY, et al. (1992). „Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives”. Biochemistry. 31 (13): 3409—14. PMID 1554722. doi:10.1021/bi00128a015.
Fournel-Gigleux S, Jackson MR, Wooster R, Burchell B (1989). „Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture”. FEBS Lett. 243 (2): 119—22. PMID 2492950. S2CID 36610635. doi:10.1016/0014-5793(89)80111-5 .
Jackson MR, McCarthy LR, Harding D, et al. (1987). „Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA”. Biochem. J. 242 (2): 581—8. PMC 1147744 . PMID 3109396. doi:10.1042/bj2420581.
Monaghan G, Clarke DJ, Povey S, et al. (1995). „Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13”. Genomics. 23 (2): 496—9. PMID 7835904. doi:10.1006/geno.1994.1531.
Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (1993). „cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily”. Biochem. Biophys. Res. Commun. 194 (1): 496—503. PMID 8333863. doi:10.1006/bbrc.1993.1847.
Babu SR, Lakshmi VM, Huang GP, et al. (1996). „Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver”. Biochem. Pharmacol. 51 (12): 1679—85. PMID 8687483. doi:10.1016/0006-2952(96)00165-7.
Monaghan G, Burchell B, Boxer M (1997). „Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase”. Mamm. Genome. 8 (9): 692—4. PMID 9271674. S2CID 31839619. doi:10.1007/s003359900539.
King CD, Rios GR, Assouline JA, Tephly TR (1999). „Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate”. Arch. Biochem. Biophys. 365 (1): 156—62. PMID 10222050. doi:10.1006/abbi.1999.1155.
Lévesque E, Beaulieu M, Hum DW, Bélanger A (1999). „Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene”. Pharmacogenetics. 9 (2): 207—16. PMID 10376768.
Strassburg CP, Kneip S, Topp J, et al. (2000). „Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine”. J. Biol. Chem. 275 (46): 36164—71. PMID 10748067. doi:10.1074/jbc.M002180200 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Barbier O, Torra IP, Sirvent A, et al. (2003). „FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity”. Gastroenterology. 124 (7): 1926—40. PMID 12806625. doi:10.1016/S0016-5085(03)00388-3.
Barbier O, Duran-Sandoval D, Pineda-Torra I, et al. (2003). „Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme”. J. Biol. Chem. 278 (35): 32852—60. PMID 12810707. doi:10.1074/jbc.M305361200 .
Saeki M, Saito Y, Jinno H, et al. (2005). „Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population”. Drug Metab. Dispos. 32 (9): 1048—54. PMID 15319348.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55—65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Barre L, Fournel-Gigleux S, Finel M, et al. (2007). „Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33”. FEBS J. 274 (5): 1256—64. PMID 17263731. S2CID 27151203. doi:10.1111/j.1742-4658.2007.05670.x .

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000035836 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] „Entrez Gene: UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4”.

[pmid3109396-5] Jackson MR, McCarthy LR, Harding D, Wilson S, Coughtrie MW, Burchell B (март 1987). „Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA”. Biochem. J. 242 (2): 581—8. PMC 1147744 . PMID 3109396. doi:10.1042/bj2420581.

[pmid7835904-6] Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (септембар 1994). „Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13”. Genomics. 23 (2): 496—9. PMID 7835904. doi:10.1006/geno.1994.1531.

[pmid17263731-7] Barre L, Fournel-Gigleux S, Finel M, Netter P, Magdalou J, Ouzzine M (март 2007). „Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33”. FEBS J. 274 (5): 1256—64. PMID 17263731. S2CID 27151203. doi:10.1111/j.1742-4658.2007.05670.x .

[pmid12806625-8] Barbier O, Torra IP, Sirvent A, Claudel T, Blanquart C, Duran-Sandoval D, Kuipers F, Kosykh V, Fruchart JC, Staels B (јун 2003). „FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity”. Gastroenterology. 124 (7): 1926—40. PMID 12806625. doi:10.1016/S0016-5085(03)00388-3.

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