B3GAT3

B3GAT3
Uygun yapılar PDB Ortolog araması: PDBe RCSB PDB kimlik kodlarının listesi 1FGG, 1KWS, 3CU0
Tanımlayıcılar
Başka adlar	B3GAT3
Dış kimlikler	OMIM: 606374 MGI: 1919977 HomoloGene: 56554 GeneCards: B3GAT3
Gen yerleşimi (İnsan) Krom. 11. Kromozom (insan)[1] Bant 11q12.3 Başlangıç 62,615,296 bç[1] Bitiş 62,622,154 bç[1]
RNA ekspresyonu deseni Daha çok ekspresyon verisi başvurusu
Gen ontolojisi Moleküler işlevi • transferase activity • protein phosphatase activator activity • glucuronosyltransferase activity • metal ion binding • GO:0001948, GO:0016582 protein bağlanması • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Hücresel bileşeni • integral component of membrane • Golgi aygıtı • membrane • cis-Golgi network • extracellular exosome • Golgi membrane Biyolojik süreci • positive regulation of intracellular protein transport • glycosaminoglycan metabolic process • heparan sulfate proteoglycan biosynthetic process • GO:0048554 positive regulation of catalytic activity • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • glycosaminoglycan biosynthetic process • chondroitin sulfate proteoglycan biosynthetic process • dermatan sulfate proteoglycan biosynthetic process • chondroitin sulfate metabolic process • carbohydrate metabolic process • regulation of phosphoprotein phosphatase activity Kaynaklar:Amigo / QuickGO
Ortologlar
Türler	İnsan	Fare
Entrez	26229	72727
Ensembl	ENSG00000149541	ENSMUSG00000071649
UniProt	O94766	P58158
RefSeq (mRNA)	NM_001288721 NM_001288722 NM_001288723 NM_012200	NM_024256
RefSeq (protein)	NP_001275650 NP_001275651 NP_001275652 NP_036332	NP_077218
Yerleşim (UCSC)	Krom. 11: 62.62 – 62.62 Mb	n/a
PubMed araması	[2]	[3]
Vikiveri
İnsan'ı Gör/Düzenle Fare'yi Gör/Düzenle

Galaktozilgalaktozilksilozilprotein 3-beta-glukuronoziltransferaz 3, insanlarda B3GAT3 geni tarafından kodlanan bir enzimdir.^[4][5]

Protein, glukuroniltransferaz gen ailesinin üyesi olan bu gen tarafından kodlanmıştır; sıkı alıcı özgüllüğü sergileyen enzimler, indirgenmeyen terminal şekerleri ve bunların anomerik bağlantılarını tanır. Bu gen ürünü, proteoglikanların bağlantı bölgesinin biyosentezinin son aşamasında bir glukuronil transfer reaksiyonu yoluyla glikozaminoglikan-protein bağlantısının oluşumunu katalizler.^[5]

Kaynakça

1. ^ GRCh38: Ensembl release 89: ENSG00000149541 - Ensembl, May 2017
2. "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
3. "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
4. "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J Biol Chem. 273 (12). Apr 1998. ss. 6615-8. 
5. ^ "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)". 5 Aralık 2010 tarihinde kaynağından arşivlendi. 

Dış bağlantılar

• Human B3GAT330 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genome location and B3GAT3 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O947667 Temmuz 2019 tarihinde Wayback Machine sitesinde arşivlendi. (Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)) at the PDBe-KB.

Konuyla ilgili yayınlar

• "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). 2005. ss. 1173-8. 
• "Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: A strategy to promote cartilage repair". Proc. Natl. Acad. Sci. U.S.A. 101 (52). 2005. ss. 18087-92. 
• "Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J. Biol. Chem. 280 (2). 2005. ss. 1417-25. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). 2004. ss. 2121-7. 
• "The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif". J. Biol. Chem. 278 (34). 2003. ss. 32219-26. 
• "Generation and initial analysis of more than 15.000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). 2003. ss. 16899-903. 
• "Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization". Biochem. J. 358 (Pt 3). 2001. ss. 539-46. 
• "Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I". J. Biol. Chem. 275 (44). 2000. ss. 34580-5. 
• "Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues". J. Biol. Chem. 275 (36). 2000. ss. 28254-60. 
• "Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". FEBS Lett. 459 (3). 1999. ss. 415-20. 
• "Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway". Proc. Natl. Acad. Sci. U.S.A. 96 (3). 1999. ss. 974-9.