CCL11

CCL11
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген CCL11[d][1]
Молекуляр функция cytokine activity[d][2], связывание с белками плазмы[d][3][4][5][…], chemokine activity[d][6][6][7], CCR3 chemokine receptor binding[d][8], protein dimerization activity[d][9], receptor ligand activity[d][8], chemokine activity[d][2][2][10][…] һәм CCR chemokine receptor binding[d][11]
Күзәнәк компоненты күзәнәк тышындагы өлкә[d][2][2][2][…], күзәнәк тышындагы мохит[d][2][2][11] һәм внутренний компонент клетки[d][6]
Биологик процесс G protein-coupled receptor signaling pathway[d][11], positive regulation of endothelial cell proliferation[d][12], positive regulation of actin filament polymerization[d][12], response to interleukin-4[d][2], branching involved in mammary gland duct morphogenesis[d][2], monocyte chemotaxis[d][11], actin filament organization[d][2], positive regulation of cell migration[d][12], chemokine-mediated signaling pathway[d][11], response to interleukin-13[d][2], cellular response to tumor necrosis factor[d][11], response to virus[d][13], cellular calcium ion homeostasis[d][14], mast cell chemotaxis[d][2], neutrophil chemotaxis[d][11], positive regulation of angiogenesis[d][2], mammary duct terminal end bud growth[d][2], хемотаксис[d][15][2], фосфорилация белка[d][15], positive regulation of GTPase activity[d][16], агрегация клеток[d][17], cytoskeleton organization[d][10], cellular response to interleukin-1[d][11], иммун җавап[d][2], positive regulation of ERK1 and ERK2 cascade[d][11], regulation of cell shape[d][10], cellular response to interferon-gamma[d][11], lymphocyte chemotaxis[d][11], response to radiation[d][18], воспалительная реакция[d][19][6], chronic inflammatory response[d][2], передача сигнала[d][15], eosinophil chemotaxis[d][6][7], antimicrobial humoral immune response mediated by antimicrobial peptide[d][20], regulation of signaling receptor activity[d][2], cytokine-mediated signaling pathway[d][2], ERK1 and ERK2 cascade[d][2], воспалительная реакция[d][18][2][11], positive regulation of GTPase activity[d][12][11] һәм eosinophil chemotaxis[d][2][10][11]
Изображение Gene Atlas

CCL11 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[21][22]

  1. 1,0 1,1 UniProt
  2. 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 GOA
  3. Hundelshausen P. V., Grommes J., Weber C. et al. Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation // Sci. Transl. Med.AAAS, 2017. — ISSN 1946-6234; 1946-6242doi:10.1126/SCITRANSLMED.AAH6650PMID:28381538
  4. Smet F. D., Bock K. D., Georgiadou M. et al. Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties // Cancer CellCell Press, Elsevier BV, 2013. — ISSN 1535-6108; 1878-3686doi:10.1016/J.CCR.2013.02.019PMID:23597562
  5. Gorrell M. D. Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α // FEBS J.Wiley-Blackwell, 2011. — ISSN 1742-464X; 0014-2956; 1742-4658; 1432-1033doi:10.1111/J.1742-4658.2011.08051.XPMID:21314817
  6. 6,0 6,1 6,2 6,3 6,4 GOA
  7. 7,0 7,1 Pease J. E. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways // J. Immunol.Baltimore: 1999. — ISSN 0022-1767; 1550-6606PMID:10072545
  8. 8,0 8,1 J Ye, Mayer K. L., Mayer M. R. et al. NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3 // Biochemistry / A. SchepartzACS, 2001. — ISSN 0006-2960; 1520-4995; 1943-295Xdoi:10.1021/BI010252SPMID:11425309
  9. Crump M. P. Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1998. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.273.35.22471PMID:9712872
  10. 10,0 10,1 10,2 10,3 Pease J. E. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways // J. Immunol.Baltimore: 1999. — ISSN 0022-1767; 1550-6606PMID:10072545
  11. 11,00 11,01 11,02 11,03 11,04 11,05 11,06 11,07 11,08 11,09 11,10 11,11 11,12 11,13 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  12. 12,0 12,1 12,2 12,3 Nozaki M., Smith J., Humbles A. A. et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy // Nature / M. SkipperNPG, Springer Science+Business Media, 2009. — ISSN 1476-4687; 0028-0836doi:10.1038/NATURE08151PMID:19525930
  13. Fauci A. S., M Dybul, AS F. et al. Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry // J. Immunol.Baltimore: 1998. — ISSN 0022-1767; 1550-6606PMID:9558100
  14. RS K., KC W., Alvarez-Hernandez X et al. Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS // J. Immunol.Baltimore: 1999. — ISSN 0022-1767; 1550-6606PMID:10415069
  15. 15,0 15,1 15,2 Kampen G. T., S Stafford, T Adachi et al. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases // BloodAmerican Society of Hematology, Elsevier BV, 2000. — ISSN 0006-4971; 1528-0020PMID:10706854
  16. Nozaki M., Smith J., Humbles A. A. et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy // Nature / M. SkipperNPG, Springer Science+Business Media, 2009. — ISSN 1476-4687; 0028-0836doi:10.1038/NATURE08151PMID:19525930
  17. T Jinquan, S Quan, G Feili et al. Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4 // J. Immunol.Baltimore: 1999. — ISSN 0022-1767; 1550-6606PMID:10201960
  18. 18,0 18,1 Huber M. A., N Kraut, T Addicks et al. Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation // Biochem. Biophys. Res. Commun.Academic Press, Elsevier BV, 2000. — ISSN 0006-291X; 1090-2104doi:10.1006/BBRC.2000.2287PMID:10708591
  19. Huber M. A., N Kraut, T Addicks et al. Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation // Biochem. Biophys. Res. Commun.Academic Press, Elsevier BV, 2000. — ISSN 0006-291X; 1090-2104doi:10.1006/BBRC.2000.2287PMID:10708591
  20. Yang D., Chen Q., Hoover D. M. et al. Many chemokines including CCL20/MIP-3alpha display antimicrobial activity. // J. Leukoc. Biol. / L. MontanerWiley-Blackwell, 2003. — ISSN 0741-5400; 1938-3673doi:10.1189/JLB.0103024PMID:12949249
  21. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  22. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)