CD33 |
|
Нинди таксонда бар |
H. sapiens[d][1] |
Кодлаучы ген |
CD33[d][1] |
Молекуляр функция |
связывание с белками плазмы[d][2][3][4][…], связывание углеводов[d][5], signaling receptor activity[d][6], protein phosphatase binding[d][7] һәм sialic acid binding[d][8][9] |
Күзәнәк компоненты |
мембрана өлеше[d][5], күзәнәк мембранасы өлеше[d][10], мембрана[d][5], наружная сторона клеточной мембраны[d][11], төш[5], күзәнәк мембранасы[d][5][10][5][…], specific granule membrane[d][5], tertiary granule membrane[d][5], пероксисома[d][5] һәм Гольджи аппараты[12] |
Биологик процесс |
передача сигнала между клетками[d][6], агрегация клеток[d][6][5], передача сигнала[d][6], негативная регуляция пролиферации клеток[d][6], regulation of immune response[d][5], neutrophil degranulation[d][5], immune response-inhibiting signal transduction[d][7], positive regulation of protein secretion[d][13], negative regulation of interleukin-1 beta production[d][8], negative regulation of interleukin-8 production[d][8], negative regulation of tumor necrosis factor production[d][8], negative regulation of calcium ion transport[d][14], cell-cell adhesion[d][9][15], positive regulation of protein tyrosine phosphatase activity[d][14] һәм negative regulation of monocyte activation[d][8] |
Тәэсир итешә |
Tenomodulin[d][16], Thrombospondin type 1 domain containing 7A[d], Stearoyl-CoA desaturase[d], cytochrome b5 type B[d] һәм Emerin[d] |
CD33 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[17][18]
- ↑ 1,0 1,1 UniProt
- ↑ Son M., Volpe B. T., Santiago-Schwarz F. et al. Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression // Sci. Rep. — Macmillan Publishers, NPG, 2017. — ISSN 2045-2322 — doi:10.1038/S41598-017-00290-W — PMID:28325905
- ↑ Dricot A., Barabási A., Tavernier J. et al. A proteome-scale map of the human interactome network // Cell — Cell Press, Elsevier BV, 2014. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2014.10.050 — PMID:25416956
- ↑ Walter R. B. ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2 // J. Leukoc. Biol. / L. Montaner — Wiley-Blackwell, 2007. — ISSN 0741-5400; 1938-3673 — doi:10.1189/JLB.0607388 — PMID:17947393
- ↑ 5,00 5,01 5,02 5,03 5,04 5,05 5,06 5,07 5,08 5,09 5,10 5,11 GOA
- ↑ 6,0 6,1 6,2 6,3 6,4 C Romagnani, M Vitale Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1999. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.96.26.15091 — PMID:10611343
- ↑ 7,0 7,1 SP P., LS T., EK S. et al. Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2 // Blood — American Society of Hematology, Elsevier BV, 2000. — ISSN 0006-4971; 1528-0020 — PMID:10887109
- ↑ 8,0 8,1 8,2 8,3 8,4 Lajaunias F., Dayer J., Chizzolini C. Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling // Eur. J. Immunol. — Wiley-Blackwell, 2005. — ISSN 0014-2980; 1521-4141 — doi:10.1002/EJI.200425273 — PMID:15597323
- ↑ 9,0 9,1 SD F., Kelm S, EK B. et al. Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules // Blood — American Society of Hematology, Elsevier BV, 1995. — 8 p. — ISSN 0006-4971; 1528-0020 — PMID:7718872
- ↑ 10,0 10,1 D Simmons, B Seed Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells // J. Immunol. — Baltimore: 1988. — ISSN 0022-1767; 1550-6606 — PMID:3139766
- ↑ Rao D. S., Baltimore D. MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2010. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.1009798107 — PMID:20660734
- ↑ Pérez-Oliva A. B., Martínez-Esparza M., Miguel R. C. et al. Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells // Glycobiology / R. S. Haltiwanger — OUP, 2011. — ISSN 0959-6658; 1460-2423 — doi:10.1093/GLYCOB/CWQ220 — PMID:21278227
- ↑ Huttunen H. J., Uronen R., Haapasalo A. FRMD4A-cytohesin signaling modulates the cellular release of tau. // J. Cell Sci. — The Company of Biologists, 2016. — ISSN 0021-9533; 1477-9137 — doi:10.1242/JCS.180745 — PMID:27044754
- ↑ 14,0 14,1 T Ulyanova, J Blasioli, Woodford-Thomas T. A. et al. The sialoadhesin CD33 is a myeloid-specific inhibitory receptor // Eur. J. Immunol. — Wiley-Blackwell, 1999. — ISSN 0014-2980; 1521-4141 — <3440::AID-IMMU3440>3.0.CO;2-C doi:10.1002/(SICI)1521-4141(199911)29:11<3440::AID-IMMU3440>3.0.CO;2-C — PMID:10556798
- ↑ Cody A. J., Freeman S. D. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1999. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.274.17.11505 — PMID:10206955
- ↑ Lambourne L., Spirohn K., Yadav A. et al. A reference map of the human binary protein interactome // Nature / M. Skipper — NPG, Springer Science+Business Media, 2020. — ISSN 1476-4687; 0028-0836 — doi:10.1038/S41586-020-2188-X — PMID:32296183
- ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
- ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
- Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
- Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)