CD59

CD59
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген CD59[d][1]
Молекуляр функция связывание с белками плазмы[d][2][3], complement binding[d][4][4] һәм complement binding[d][5]
Күзәнәк компоненты везикула[d][6], endoplasmic reticulum membrane[d][7], мембрана[d][8][7], фокальные контакты[d][9], Golgi membrane[d][7], күзәнәк мембранасы[d][4][10][4][…], күзәнәк тышындагы өлкә[d][7], күзәнәк өслеге[d][11], compact myelin[d][4], anchored component of external side of plasma membrane[d][12], ER to Golgi transport vesicle membrane[d][7], anchored component of membrane[d][7], Сарколемма[d][4], экзосома[d][13][14][15][…], endoplasmic reticulum-Golgi intermediate compartment membrane[d][7], күзәнәк тышындагы мохит[d][4][16], specific granule membrane[d][7], tertiary granule membrane[d][7], transport vesicle[d][7], күзәнәк тышындагы мохит[d][17], күзәнәк мембранасы[d][7][8][7][…], фокальные контакты[d][18], күзәнәк өслеге[d][19][5], везикула[d][20] һәм экзосома[d][21][22][23][…]
Биологик процесс cвёртывание крови[d][8], негативная регуляция апоптоза[d][4], negative regulation of activation of membrane attack complex[d][7], endoplasmic reticulum to Golgi vesicle-mediated transport[d][7], cell surface receptor signaling pathway[d][24], COPII vesicle coating[d][7], positive regulation of T cell proliferation[d][4], regulation of complement activation[d][4][4], cell activation[d][4], neutrophil degranulation[d][7], regulation of complement activation[d][7], regulation of complement activation[d][7][25], regulation of complement-dependent cytotoxicity[d][25] һәм negative regulation of activation of membrane attack complex[d][7][5]
Изображение Gene Atlas
 CD59 Викиҗыентыкта

CD59 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[26][27]

  1. 1,0 1,1 UniProt
  2. Ni B. Hepatitis B virus core protein interacts with CD59 to promote complement-mediated liver inflammation during chronic hepatitis B virus infection // FEBS LettersElsevier BV, 2013. — ISSN 0014-5793; 1873-3468doi:10.1016/J.FEBSLET.2013.08.044PMID:24036449
  3. Bonnon C., Wendeler M. W., Paccaud J. et al. Selective export of human GPI-anchored proteins from the endoplasmic reticulum // J. Cell Sci.The Company of Biologists, 2010. — ISSN 0021-9533; 1477-9137doi:10.1242/JCS.062950PMID:20427317
  4. 4,00 4,01 4,02 4,03 4,04 4,05 4,06 4,07 4,08 4,09 4,10 4,11 GOA
  5. 5,0 5,1 5,2 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  6. Pickles R. J. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense // FASEB J.FASEB, 2009. — ISSN 0892-6638; 1530-6860doi:10.1096/FJ.08-119131PMID:19190083
  7. 7,00 7,01 7,02 7,03 7,04 7,05 7,06 7,07 7,08 7,09 7,10 7,11 7,12 7,13 7,14 7,15 7,16 7,17 7,18 GOA
  8. 8,0 8,1 8,2 Petranka J. G., Fleenor D. E., K. Sykes et al. Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 1992. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.89.17.7876PMID:1381503
  9. Waterman C. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol.NPG, 2011. — ISSN 1465-7392; 1476-4679doi:10.1038/NCB2216PMID:21423176
  10. Petranka J. G., Fleenor D. E., K. Sykes et al. Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 1992. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.89.17.7876PMID:1381503
  11. Jian-Hua T., Xiao-Jie Z., Yi-Dan W. et al. Effect of glycosylphosphatidylinositol specific phospholipase D gene expression levels on complement mediated killing of leukemic cells in patients with chronic myeloid leukemia // Clin. Chim. ActaElsevier BV, 2005. — ISSN 0009-8981; 1873-3492doi:10.1016/J.CCCN.2005.03.045PMID:15907827
  12. Maeda Y, Tomita S, Watanabe R et al. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate // EMBO J.NPG, 1998. — ISSN 0261-4189; 1460-2075doi:10.1093/EMBOJ/17.17.4920PMID:9724629
  13. Farina A., Lane L., Lescuyer P. et al. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine // Journal of ProteomicsElsevier BV, 2013. — ISSN 1874-3919; 0165-022Xdoi:10.1016/J.JPROT.2013.01.012PMID:23376485
  14. Pisitkun T., Tchapyjnikov D., Knepper M. A. Large-scale proteomics and phosphoproteomics of urinary exosomes // Journal of the American Society of Nephrology / J. BriggsAmerican Society of Nephrology, 2008. — ISSN 1046-6673; 1533-3450doi:10.1681/ASN.2008040406PMID:19056867
  15. Gonzalez-Begne M., Lu B., Han X. et al. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT) // J. Proteome Res. / J. YatesACS, 2009. — ISSN 1535-3893; 1535-3907doi:10.1021/PR800658CPMID:19199708
  16. Palmer D. J., Kelly V. C., Smit A. et al. Human colostrum: identification of minor proteins in the aqueous phase by proteomics // Proteomics / L. StimsonWiley, 2006. — ISSN 1615-9853; 1615-9861doi:10.1002/PMIC.200500558PMID:16502470
  17. Palmer D. J., Kelly V. C., Smit A. et al. Human colostrum: identification of minor proteins in the aqueous phase by proteomics // Proteomics / L. StimsonWiley, 2006. — ISSN 1615-9853; 1615-9861doi:10.1002/PMIC.200500558PMID:16502470
  18. Waterman C. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol.NPG, 2011. — ISSN 1465-7392; 1476-4679doi:10.1038/NCB2216PMID:21423176
  19. Jian-Hua T., Xiao-Jie Z., Yi-Dan W. et al. Effect of glycosylphosphatidylinositol specific phospholipase D gene expression levels on complement mediated killing of leukemic cells in patients with chronic myeloid leukemia // Clin. Chim. ActaElsevier BV, 2005. — ISSN 0009-8981; 1873-3492doi:10.1016/J.CCCN.2005.03.045PMID:15907827
  20. Pickles R. J. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense // FASEB J.FASEB, 2009. — ISSN 0892-6638; 1530-6860doi:10.1096/FJ.08-119131PMID:19190083
  21. Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell BiologyWiley, 2010. — ISSN 0818-9641; 1440-1711doi:10.1038/ICB.2010.64PMID:20458337
  22. Sinha A., Kislinger T. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine // Proteomics / L. StimsonWiley, 2013. — ISSN 1615-9853; 1615-9861doi:10.1002/PMIC.201200561PMID:23533145
  23. Gonzalez-Begne M., Lu B., Han X. et al. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT) // J. Proteome Res. / J. YatesACS, 2009. — ISSN 1535-3893; 1535-3907doi:10.1021/PR800658CPMID:19199708
  24. Heyningen V. v. Colocalization of the human CD59 gene to 11p13 with the MIC11 cell surface antigen // Genomics / A. EngelAcademic Press, Elsevier BV, 1993. — ISSN 0888-7543; 1089-8646doi:10.1006/GENO.1993.1293PMID:7691713
  25. 25,0 25,1 Mori M., Ohara O. Circulating AIM Prevents Hepatocellular Carcinoma through Complement Activation // Cell ReportsCell Press, Elsevier BV, 2014. — ISSN 2211-1247; 2639-1856doi:10.1016/J.CELREP.2014.08.058PMID:25284781
  26. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  27. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)