ERCC2

ERCC2
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген ERCC2[d][1]
Молекуляр функция ДНК-связывающий[d][2][2], 4 iron, 4 sulfur cluster binding[d][2], protein kinase activity[d][3], ATP-dependent activity, acting on DNA[d][4][3], нуклеотид-связывающий[d][2], helicase activity[d][2][2], protein N-terminus binding[d][5], iron-sulfur cluster binding[d][2], DNA helicase activity[d][6], связывание с ионом металла[d][2], hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides[d][2], protein C-terminus binding[d][7], связывание с белками плазмы[d][8][5][9][…], nucleic acid binding[d][2], RNA polymerase II CTD heptapeptide repeat kinase activity[d][10], 5'-3' DNA helicase activity[d][9][4], гидролазная активность[d][2], АТФ-связанные[d][2][2], damaged DNA binding[d][11], DNA helicase activity[d][2][11], RNA polymerase II CTD heptapeptide repeat kinase activity[d][3][11], protein-macromolecule adaptor activity[d][9] һәм 5'-3' DNA helicase activity[d][11]
Күзәнәк компоненты цитоплазма[2][8][12], cyclin-dependent protein kinase activating kinase holoenzyme complex[d][13][14], веретено деления[d][2][12], transcription factor TFIIH holo complex[d][15][3], transcription factor TFIIH core complex[d][2], цитоскелет[d][2], төш[6][6][6][…], MMXD complex[d][12], нуклеоплазма[d][2][2], transcription factor TFIID complex[d][16], цитозоль[d][2], төш[2][2][2][…] һәм CAK-ERCC2 complex[d][17][9]
Биологик процесс termination of RNA polymerase I transcription[d][2], regulation of mitotic cell cycle phase transition[d][18], bone mineralization[d][2], hair cycle process[d][2], response to hypoxia[d][2], ДНК-зависимая регуляция транскрипции[d][6], embryonic cleavage[d][2], hair follicle maturation[d][2], multicellular organism growth[d][2], chromosome segregation[d][12][2], transcription initiation from RNA polymerase I promoter[d][2], transcription elongation from RNA polymerase II promoter[d][2], hair cell differentiation[d][19][2], старение человека[d][2], extracellular matrix organization[d][2], in utero embryonic development[d][2], 7-methylguanosine mRNA capping[d][2], transcription by RNA polymerase II[d][20][6][10], post-embryonic development[d][2], response to oxidative stress[d][21][6], транскрипция, ДНК-зависимая[d][6], cellular response to DNA damage stimulus[d][2], ДНК-зависимая позитивная регуляция транскрипции[d][14], global genome nucleotide-excision repair[d][2], hematopoietic stem cell differentiation[d][2], арка мие үсеше[d][2], УФ-защита[d][22][2], positive regulation of DNA binding[d][2], central nervous system myelin formation[d][2], transcription-coupled nucleotide-excision repair[d][2][4], transcription initiation from RNA polymerase II promoter[d][2], пролиферация[d][2], nucleotide-excision repair, DNA incision[d][6][23], nucleobase-containing compound metabolic process[d][2], response to UV[d][6], положительная регуляция транскрипции РНК полимеразой II промотор[d][24], развитие кожи[d][2], erythrocyte maturation[d][2], апоптоз[d][25], Эксцизионная репарация нуклеотидов[d][26][22][2][…], nucleotide-excision repair, preincision complex stabilization[d][2], репарация ДНК[d][2][2], вирусный процесс[d][2], фосфорилация белка[d][2], nucleotide-excision repair, preincision complex assembly[d][2], nucleotide-excision repair, DNA incision, 5'-to lesion[d][2], развитие эмбрионического органа[d][2], DNA duplex unwinding[d][6], regulation of mitotic recombination[d][11], nucleotide-excision repair, DNA duplex unwinding[d][27], transcription by RNA polymerase II[d][4][2][3][…], response to oxidative stress[d][28][2][11], response to UV[d][2][11], nucleotide-excision repair, DNA incision[d][2][24][11], ДНК-зависимая позитивная регуляция транскрипции[d][17][11], positive regulation of mitotic recombination[d][11], nucleotide-excision repair, DNA duplex unwinding[d][2][11], nucleotide-excision repair, DNA incision, 3'-to lesion[d][2] һәм transcription elongation from RNA polymerase I promoter[d][2]
Изображение Gene Atlas

ERCC2 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[29][30]

  1. 1,0 1,1 UniProt
  2. 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 2,29 2,30 2,31 2,32 2,33 2,34 2,35 2,36 2,37 2,38 2,39 2,40 2,41 2,42 2,43 2,44 2,45 2,46 2,47 2,48 2,49 2,50 2,51 2,52 2,53 2,54 2,55 2,56 2,57 2,58 2,59 2,60 2,61 2,62 2,63 2,64 2,65 2,66 2,67 2,68 GOA
  3. 3,0 3,1 3,2 3,3 3,4 E Kershnar, Wu S. Y., Chiang C. M. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1998. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.273.51.34444PMID:9852112
  4. 4,0 4,1 4,2 4,3 Egly J., Hoeijmakers J. H., T Seroz A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1996. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.271.27.15898PMID:8663148
  5. 5,0 5,1 N Iyer, Reagan M. S., Wu K. J. et al. Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein // Biochemistry / A. SchepartzACS, 1996. — ISSN 0006-2960; 1520-4995; 1943-295Xdoi:10.1021/BI9524124PMID:8652557
  6. 6,00 6,01 6,02 6,03 6,04 6,05 6,06 6,07 6,08 6,09 6,10 GOA
  7. Egly J. M., O Gileadi Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2000. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M002578200PMID:10801852
  8. 8,0 8,1 Seki M., Takeda Y., Iwai K. et al. IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2013. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M112.416602PMID:23585563
  9. 9,0 9,1 9,2 9,3 Egly J. M. A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2001. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M105570200PMID:11445587
  10. 10,0 10,1 E Kershnar, Wu S. Y., Chiang C. M. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1998. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.273.51.34444PMID:9852112
  11. 11,00 11,01 11,02 11,03 11,04 11,05 11,06 11,07 11,08 11,09 11,10 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  12. 12,0 12,1 12,2 12,3 Hirano Y., Kuraoka I., Hiraoka Y. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation // Mol. CellCell Press, Elsevier BV, 2010. — ISSN 1097-2765; 1097-4164doi:10.1016/J.MOLCEL.2010.07.029PMID:20797633
  13. Egly J. M. A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2001. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M105570200PMID:11445587
  14. 14,0 14,1 Drapkin R. Human cyclin-dependent kinase-activating kinase exists in three distinct complexes // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 1996. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.93.13.6488PMID:8692842
  15. Egly J., L. Schaeffer, V. Moncollin et al. p53 modulation of TFIIH-associated nucleotide excision repair activity, p53 modulation of TFIIH–associated nucleotide excision repair activity // Nature Genetics / M. Axton, T. FaialNPG, 1995. — ISSN 1061-4036; 1546-1718doi:10.1038/NG0695-188PMID:7663514
  16. Nogales E., Tjian R. Near-atomic resolution visualization of human transcription promoter opening // Nature / M. SkipperNPG, Springer Science+Business Media, 2016. — ISSN 1476-4687; 0028-0836doi:10.1038/NATURE17970PMID:27193682
  17. 17,0 17,1 Drapkin R. Human cyclin-dependent kinase-activating kinase exists in three distinct complexes // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 1996. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.93.13.6488PMID:8692842
  18. Marini F., Giannattasio M., Plevani P. et al. DNA nucleotide excision repair-dependent signaling to checkpoint activation // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 2006. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.0605446103PMID:17088560
  19. Egly J. Trichothiodystrophy, a transcription syndrome // Trends in GeneticsElsevier BV, 2001. — ISSN 0168-9525; 1362-4555doi:10.1016/S0168-9525(01)02280-6PMID:11335038
  20. Egly J., Hoeijmakers J. H., T Seroz A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1996. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.271.27.15898PMID:8663148
  21. Kirsch-Volders M., Roelants M. Genetic susceptibility of newborn daughters to oxidative stress // Toxicol. Lett.Elsevier BV, 2007. — ISSN 0378-4274; 1879-3169doi:10.1016/J.TOXLET.2007.05.014PMID:17614221
  22. 22,0 22,1 Weber C. A., Salazar E. P., Stewart S. A. et al. Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells // Mol. Cell. Biol.ASM, 1988. — ISSN 0270-7306; 1098-5549; 1067-8824doi:10.1128/MCB.8.3.1137PMID:2835663
  23. Sancar A. Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 1996. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.93.13.6482PMID:8692841
  24. 24,0 24,1 Sancar A. Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 1996. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.93.13.6482PMID:8692841
  25. Hoeijmakers J. H. The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway // Genes Dev.Cold Spring Harbor Laboratory Press, 1996. — ISSN 0890-9369; 1549-5477doi:10.1101/GAD.10.10.1219PMID:8675009
  26. CA W., EP S., SA S. et al. ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3 // EMBO J.NPG, 1990. — ISSN 0261-4189; 1460-2075doi:10.1002/J.1460-2075.1990.TB08260.XPMID:2184031
  27. Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  28. Kirsch-Volders M., Roelants M. Genetic susceptibility of newborn daughters to oxidative stress // Toxicol. Lett.Elsevier BV, 2007. — ISSN 0378-4274; 1879-3169doi:10.1016/J.TOXLET.2007.05.014PMID:17614221
  29. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  30. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
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