FOXE1 |
Нинди таксонда бар |
H. sapiens[d][1] |
Кодлаучы ген |
FOXE1[d][1] |
Молекуляр функция |
DNA-binding transcription factor activity[d][2][3], sequence-specific DNA binding[d][4][5][6][…], ДНК-связывающий[d][2][2], DNA-binding transcription factor activity, RNA polymerase II-specific[d][7][7][8][…] һәм DNA-binding transcription factor activity, RNA polymerase II-specific[d][9][9][2][…] |
Күзәнәк компоненты |
төш[8][10][11] һәм төш[2][5][3][…] |
Биологик процесс |
ДНК-зависимая позитивная регуляция транскрипции[d][3], soft palate development[d][6], hair follicle morphogenesis[d][2][2], thyroid hormone generation[d][2][2], развитие щитовидной железы[d][3][12][2], negative regulation of transcription, DNA-templated[d][2], pharynx development[d][12], negative regulation of transcription by RNA polymerase II[d][13][2][2], миграция клеток[d][2][2], embryonic organ morphogenesis[d][2][2], ДНК-зависимая регуляция транскрипции[d][2], hard palate development[d][6], транскрипция, ДНК-зависимая[d][8], тимус үсеше[d][12], roof of mouth development[d][2], cranial skeletal system development[d][2], regulation of transcription by RNA polymerase II[d][14][15][10][…], морфогенез анатомической структуры[d][13][16], дифференцировка клеток[d][16] һәм regulation of transcription by RNA polymerase II[d][4][5][6][…] |
FOXE1 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[17][18]
- ↑ 1,0 1,1 UniProt
- ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 GOA
- ↑ 3,0 3,1 3,2 3,3 Clifton-Bligh R. J., Lazarus J., Ludgate M. Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia // Nature Genetics / M. Axton, T. Faial — NPG, 1998. — ISSN 1061-4036; 1546-1718 — doi:10.1038/1294 — PMID:9697705
- ↑ 4,0 4,1 I. Baris, Arisoy A. E., A. Smith et al. A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis // J. Clin. Endocrinol. Metab. / R. Paul Robertson — Endocrine Society, 2006. — ISSN 0021-972X; 1945-7197; 0096-7173; 0368-1610 — doi:10.1210/JC.2006-0405 — PMID:16882747
- ↑ 5,0 5,1 5,2 Venza I., Visalli M., Parrillo L. et al. MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1 // Human Molecular Genetics — OUP, 2011. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/DDQ547 — PMID:21177256
- ↑ 6,0 6,1 6,2 6,3 Lyonnet S., Pelet A. A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate // Human Molecular Genetics — OUP, 2002. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/11.17.2051 — PMID:12165566
- ↑ 7,0 7,1 Vaquerizas J. M., Teichmann S., Kummerfeld S. K. A census of human transcription factors: function, expression and evolution // Nature reviews. Genetics — United Kingdom: NPG, 2009. — ISSN 1471-0056; 1471-0064 — doi:10.1038/NRG2538 — PMID:19274049
- ↑ 8,0 8,1 8,2 GOA
- ↑ 9,0 9,1 Vaquerizas J. M., Teichmann S., Kummerfeld S. K. A census of human transcription factors: function, expression and evolution // Nature reviews. Genetics — United Kingdom: NPG, 2009. — ISSN 1471-0056; 1471-0064 — doi:10.1038/NRG2538 — PMID:19274049
- ↑ 10,0 10,1 Venza I., Visalli M., Parrillo L. et al. MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1 // Human Molecular Genetics — OUP, 2011. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/DDQ547 — PMID:21177256
- ↑ Clifton-Bligh R. J., Lazarus J., Ludgate M. Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia // Nature Genetics / M. Axton, T. Faial — NPG, 1998. — ISSN 1061-4036; 1546-1718 — doi:10.1038/1294 — PMID:9697705
- ↑ 12,0 12,1 12,2 Attié-Bitach T., Vekemans M., Etchevers H. PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations // J. Clin. Endocrinol. Metab. / R. Paul Robertson — Endocrine Society, 2005. — ISSN 0021-972X; 1945-7197; 0096-7173; 0368-1610 — doi:10.1210/JC.2004-1358 — PMID:15494458
- ↑ 13,0 13,1 Chadwick B. P., F Obermayr, Frischauf A. M. FKHL15, a new human member of the forkhead gene family located on chromosome 9q22 // Genomics / A. Engel — Academic Press, Elsevier BV, 1997. — ISSN 0888-7543; 1089-8646 — doi:10.1006/GENO.1997.4692 — PMID:9169137
- ↑ Mallya U. Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism // J. Clin. Endocrinol. Metab. / R. Paul Robertson — Endocrine Society, 2010. — ISSN 0021-972X; 1945-7197; 0096-7173; 0368-1610 — doi:10.1210/JC.2010-0275 — PMID:20484477
- ↑ Lyonnet S., Pelet A. A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate // Human Molecular Genetics — OUP, 2002. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/11.17.2051 — PMID:12165566
- ↑ 16,0 16,1 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
- ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
- ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
- Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
- Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)