NF2

NF2
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген Мерлин[d][1]
Молекуляр функция cytoskeletal protein binding[d][2], связывание с белками плазмы[d][3][4][5][…] һәм actin binding[d][2]
Күзәнәк компоненты цитоплазма[2][2][6], cell body[d][2], cell projection[d][2], мембрана[d][7][8], filopodium[d][2], ruffle[d][2], Адгезионные контакты[d][2], күзәнәк мембранасы[d][2][2][9][…], apical part of cell[d][2], ruffle membrane[d][2], early endosome[d][10], ядрышко[d][6], cortical actin cytoskeleton[d][2], perinuclear region of cytoplasm[d][2][11], neuron projection[d][2], cleavage furrow[d][2], цитоскелет[d][12][2][2][…], төш[2][2][13][…], lamellipodium[d][2], filopodium membrane[d][2], цитозоль[d][2] һәм мембрана[d][2][14]
Биологик процесс negative regulation of receptor signaling pathway via JAK-STAT[d][15], regulation of gliogenesis[d][2], cell-cell junction organization[d][2], regulation of protein stability[d][2], negative regulation of cell-cell adhesion[d][11], negative regulation of protein kinase activity[d][2], mesoderm formation[d][2], ectoderm development[d][2], negative regulation of DNA replication[d][16], Schwann cell proliferation[d][17], regulation of neural precursor cell proliferation[d][2], regulation of protein localization to nucleus[d][2], negative regulation of cell-matrix adhesion[d][11], odontogenesis of dentin-containing tooth[d][2], развитие мозга[d][2], negative regulation of cell migration[d][11], lens fiber cell differentiation[d][2], regulation of cell population proliferation[d][2], positive regulation of cell differentiation[d][2], negative regulation of MAPK cascade[d][2], regulation of hippo signaling[d][18], развитие гиппокампа[d][2], regulation of stem cell proliferation[d][2], regulation of neurogenesis[d][2], actin cytoskeleton organization[d][6], positive regulation of stress fiber assembly[d][6], негативная регуляция пролиферации клеток[d][11][2][13][…], negative regulation of tyrosine phosphorylation of STAT protein[d][15], regulation of apoptotic process[d][5] һәм regulation of cell cycle[d][5]
Изображение Gene Atlas

NF2 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[19][20]

Искәрмәләр

[үзгәртү | вики-текстны үзгәртү]
  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 2,29 2,30 2,31 2,32 2,33 2,34 2,35 2,36 2,37 2,38 2,39 2,40 2,41 2,42 GOA
  3. ↑ Bolino A., Chishti A. H. Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin // Exp. Biol. Med. — SAGE Publishing, Frontiers Media, 2009. — ISSN 1535-3702; 1535-3699 — doi:10.3181/0809-RM-275 — PMID:19144871
  4. ↑ Morales F. C., Takahashi Y., Momin S. et al. NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands // Mol. Cell. Biol. — ASM, 2007. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.01372-06 — PMID:17242191
  5. ↑ 5,0 5,1 5,2 Mei L. Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus, Moesin–ezrin–radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus // Int. J. Biochem. Cell Biol. — Elsevier, 2010. — ISSN 1357-2725; 0020-711X; 1878-5875 — doi:10.1016/J.BIOCEL.2010.12.011 — PMID:21167305
  6. ↑ 6,0 6,1 6,2 6,3 Scoles D. R., Huynh D. P., Morcos P. A. et al. Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin, Neurofibromatosis 2 tumour suppressor schwannomin interacts with βII-spectrin // Nature Genetics / M. Axton, T. Faial — NPG, 1998. — ISSN 1061-4036; 1546-1718 — doi:10.1038/NG0498-354 — PMID:9537418
  7. ↑ GOA
  8. ↑ Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom. — Wiley, 2010. — ISSN 1076-5174; 1096-9888 — doi:10.1002/JMS.1696 — PMID:19946888
  9. ↑ B Schmucker, Y Tang, M Kressel Novel alternatively spliced isoforms of the neurofibromatosis type 2 tumor suppressor are targeted to the nucleus and cytoplasmic granules // Human Molecular Genetics — OUP, 1999. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/8.8.1561 — PMID:10401006
  10. ↑ Scoles D. R., Huynh D. P., Chen M. S. et al. The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate // Human Molecular Genetics — OUP, 2000. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/9.11.1567 — PMID:10861283
  11. ↑ 11,0 11,1 11,2 11,3 11,4 Lee H., Kim D., Dan H. C. et al. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein // Mol. Cell. Biol. — ASM, 2007. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.00572-06 — PMID:17210637
  12. ↑ C Desmaze Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2 // Nature / M. Skipper — NPG, Springer Science+Business Media, 1993. — ISSN 1476-4687; 0028-0836 — doi:10.1038/363515A0 — PMID:8379998
  13. ↑ 13,0 13,1 Erdjument-Bromage H., Tempst P., Li W. et al. Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus // Cell — Cell Press, Elsevier, 2010. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2010.01.029 — PMID:20178741
  14. ↑ Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom. — Wiley, 2010. — ISSN 1076-5174; 1096-9888 — doi:10.1002/JMS.1696 — PMID:19946888
  15. ↑ 15,0 15,1 Morrison H., Gutmann D. H. Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling // Human Molecular Genetics — OUP, 2002. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/11.25.3179 — PMID:12444102
  16. ↑ Lee H., Kim D., Dan H. C. et al. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein // Mol. Cell. Biol. — ASM, 2007. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.00572-06 — PMID:17210637
  17. ↑ McLaughlin M. E., Pepin S. M., Maccollin M. et al. Ocular pathologic findings of neurofibromatosis type 2 // JAMA Ophthalmology — AMA, 2007. — ISSN 0003-9950; 1538-3601; 2168-6165; 2168-6173 — doi:10.1001/ARCHOPHT.125.3.389 — PMID:17353411
  18. ↑ Yu J., Zheng Y., Dong J. et al. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded // Developmental Cell — Elsevier, 2010. — ISSN 1534-5807; 1878-1551 — doi:10.1016/J.DEVCEL.2009.12.012 — PMID:20159598
  19. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  20. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

[үзгәртү | вики-текстны үзгәртү]
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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