SCARB1

SCARB1
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген SCARB1[d][1]
Молекуляр функция apolipoprotein binding[d][2][3], гомодимеризация белка[d][3], virus receptor activity[d][3], transporter activity[d][4], high-density lipoprotein particle receptor activity[d][5][4], phosphatidylserine binding[d][3][3], apolipoprotein A-I binding[d][2][6], lipopolysaccharide binding[d][6], low-density lipoprotein particle binding[d][4], 1-phosphatidylinositol binding[d][4], связывание с белками плазмы[d][7][8][8], high-density lipoprotein particle binding[d][3], lipopolysaccharide immune receptor activity[d][6], amyloid-beta binding[d][3] һәм scavenger receptor activity[d][9]
Күзәнәк компоненты цитоплазма[3], мембрана өлеше[d][3][3], endocytic vesicle membrane[d][3], intracellular membrane-bounded organelle[d][3], мембрана[d][3][3], күзәнәк мембранасы[d][3][3][4], күзәнәк мембранасы өлеше[d][3], күзәнәк өслеге[d][10][3], lysosomal membrane[d][11], Кавеола[d][6][3][3], экзосома[d][12], microvillus membrane[d][3], lysosomal membrane[d][13] һәм экзосома[d][14]
Биологик процесс cholesterol import[d][15][16][5][…], positive regulation of triglyceride biosynthetic process[d][3][3], regulation of phosphatidylcholine catabolic process[d][3][3], recognition of apoptotic cell[d][3][4], lipid transport[d][3], low-density lipoprotein particle clearance[d][3][3], blood vessel endothelial cell migration[d][3], positive regulation of cholesterol storage[d][4], phospholipid transport[d][3][3], cholesterol transport[d][3], Заживление ран[d][17], cholesterol catabolic process[d][3], рецепторно-опосредованный эндоцитоз[d][3], high-density lipoprotein particle remodeling[d][3][3], positive regulation of endothelial cell migration[d][17], androgen biosynthetic process[d][3], vitamin transmembrane transport[d][5], positive regulation of nitric-oxide synthase activity[d][18], endothelial cell proliferation[d][3], lipopolysaccharide transport[d][6], cholesterol efflux[d][15][19][3], phagocytosis, recognition[d][3], viral entry into host cell[d][3], intestinal absorption[d][3], cholesterol homeostasis[d][3][3], regulation of phagocytosis[d][3][4], adhesion of symbiont to host[d][20], вирусный процесс[d][3], detection of lipopolysaccharide[d][6], triglyceride homeostasis[d][3][3], reverse cholesterol transport[d][4][3], lipopolysaccharide-mediated signaling pathway[d][3] һәм high-density lipoprotein particle clearance[d][3][4]
Тәэсир итешә Viroporin 3a[d][21]

SCARB1 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[22][23]

Искәрмәләр

[үзгәртү | вики-текстны үзгәртү]
  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 Fruchart J. C., S Lestavel Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake // Arteriosclerosis, Thrombosis, and Vascular Biology — Lippincott Williams & Wilkins, 2000. — ISSN 1079-5642; 1524-4636 — doi:10.1161/01.ATV.20.4.1074 — PMID:10764676
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 3,12 3,13 3,14 3,15 3,16 3,17 3,18 3,19 3,20 3,21 3,22 3,23 3,24 3,25 3,26 3,27 3,28 3,29 3,30 3,31 3,32 3,33 3,34 3,35 3,36 3,37 3,38 3,39 3,40 3,41 3,42 3,43 3,44 3,45 3,46 3,47 3,48 3,49 3,50 3,51 GOA
  4. ↑ 4,00 4,01 4,02 4,03 4,04 4,05 4,06 4,07 4,08 4,09 K. Murao, V. Terpstra, Green S. R. et al. Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.272.28.17551 — PMID:9211901
  5. ↑ 5,0 5,1 5,2 D Goti, A Hrzenjak, S Levak-Frank et al. Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E // J. Neurochem. — Wiley-Blackwell, 2001. — ISSN 0022-3042; 1471-4159 — doi:10.1046/J.1471-4159.2001.00100.X — PMID:11208913
  6. ↑ 6,0 6,1 6,2 6,3 6,4 6,5 Vishnyakova T. G., Remaley A. T. Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2003. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M211032200 — PMID:12651854
  7. ↑ Dricot A., Barabási A., Tavernier J. et al. A proteome-scale map of the human interactome network // Cell — Cell Press, Elsevier BV, 2014. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2014.10.050 — PMID:25416956
  8. ↑ 8,0 8,1 Scarselli E. The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus // EMBO J. — NPG, 2002. — ISSN 0261-4189; 1460-2075 — doi:10.1093/EMBOJ/CDF529 — PMID:12356718
  9. ↑ Husemann J, JD L., Kodama T et al. Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid // J. Neuroimmunol. — Elsevier BV, 2001. — ISSN 0165-5728; 1872-8421 — doi:10.1016/S0165-5728(01)00239-9 — PMID:11240025
  10. ↑ Ji A., Meyer J. M., Cai L. et al. Scavenger receptor SR-BI in macrophage lipid metabolism // Atherosclerosis — Elsevier BV, 2011. — ISSN 0021-9150; 1879-1484 — doi:10.1016/J.ATHEROSCLEROSIS.2011.03.017 — PMID:21481393
  11. ↑ Schröder B., Wrocklage C., Pan C. et al. Integral and associated lysosomal membrane proteins // Traffic — Wiley-Blackwell, 2007. — ISSN 1398-9219; 1600-0854 — doi:10.1111/J.1600-0854.2007.00643.X — PMID:17897319
  12. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  13. ↑ Schröder B., Wrocklage C., Pan C. et al. Integral and associated lysosomal membrane proteins // Traffic — Wiley-Blackwell, 2007. — ISSN 1398-9219; 1600-0854 — doi:10.1111/J.1600-0854.2007.00643.X — PMID:17897319
  14. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  15. ↑ 15,0 15,1 Phillips M. C. Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2004. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M311718200 — PMID:14718538
  16. ↑ Deloukas P., Trompet S., Salomaa V. et al. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease // Science / H. Thorp — Northern America: AAAS, 2016. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.AAD3517 — PMID:26965621
  17. ↑ 17,0 17,1 Mineo C., Shaul P. W. Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair // Trends in Cardiovascular Medicine — Elsevier BV, 2007. — ISSN 1050-1738; 1873-2615 — doi:10.1016/J.TCM.2007.03.005 — PMID:17574123
  18. ↑ Li X., Titlow W. B., Jackson B. A. et al. High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M110985200 — PMID:11792700
  19. ↑ Panzenboeck U., Balazs Z., Sovic A. et al. ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M207601200 — PMID:12202492
  20. ↑ Seyec J. L. Entry of pseudotyped hepatitis C virus into primary human hepatocytes depends on the scavenger class B type I receptor // Journal of Viral Hepatitis — Wiley-Blackwell, 2008. — ISSN 1352-0504; 1365-2893; 1345-2533 — doi:10.1111/J.1365-2893.2008.01048.X — PMID:19087225
  21. ↑ BioGRID
  22. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  23. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

[үзгәртү | вики-текстны үзгәртү]
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


Миоглобин молекуласы
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