SPN |
Нинди таксонда бар |
H. sapiens[d][1] |
Кодлаучы ген |
Лейкосиалин[d][1] |
Молекуляр функция |
transmembrane signaling receptor activity[d][2], Hsp70 protein binding[d][3] һәм heat shock protein binding[d][3][4] |
Күзәнәк компоненты |
мембрана өлеше[d][4], мембрана[d][4][5], күзәнәк мембранасы[d][4], күзәнәк мембранасы өлеше[d][6][4], базаль мембрана[d][4], күзәнәк өслеге[d][7], uropod[d][4], экзосома[d][8], наружная сторона клеточной мембраны[d][4] һәм күзәнәк тышындагы мохит[d][9] |
Биологик процесс |
negative regulation of cell adhesion[d][10][4], positive regulation of protein phosphorylation[d][4], negative regulation of type IV hypersensitivity[d][4], response to protozoan[d][4], T cell costimulation[d][4], negative thymic T cell selection[d][4], хемотаксис[d][10], establishment or maintenance of cell polarity[d][10], cellular defense response[d][2], cell surface receptor signaling pathway[d][4], negative regulation of T cell proliferation[d][4], defense response to bacterium[d][4][9], иммун җавап[d][6], positive regulation of T cell proliferation[d][4], regulation of immune response[d][4], apoptotic signaling pathway[d][4], regulation of defense response to virus[d][4], negative regulation of T cell activation[d][4], leukocyte migration[d][4] һәм передача сигнала[d][6] |
SPN (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[11][12]
- ↑ 1,0 1,1 UniProt
- ↑ 2,0 2,1 Burakoff S. J., Bierer B. E., Hahn W. C. CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1 // Nature / M. Skipper — NPG, Springer Science+Business Media, 1991. — ISSN 1476-4687; 0028-0836 — doi:10.1038/354233A0 — PMID:1683685
- ↑ 3,0 3,1 Tyler B M Hickey, Ziltener H. J., Speert D. P. et al. Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface // Cellular Microbiology — Wiley-Blackwell, 2010. — ISSN 1462-5814; 1462-5822 — doi:10.1111/J.1462-5822.2010.01496.X — PMID:20633027
- ↑ 4,00 4,01 4,02 4,03 4,04 4,05 4,06 4,07 4,08 4,09 4,10 4,11 4,12 4,13 4,14 4,15 4,16 4,17 4,18 4,19 4,20 4,21 4,22 GOA
- ↑ Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom. — Wiley, 2010. — ISSN 1076-5174; 1096-9888 — doi:10.1002/JMS.1696 — PMID:19946888
- ↑ 6,0 6,1 6,2 Burakoff S. J., Bierer B. E., E Remold-O'Donnell Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome // Nature / M. Skipper — NPG, Springer Science+Business Media, 1991. — ISSN 1476-4687; 0028-0836 — doi:10.1038/350706A0 — PMID:2023632
- ↑ Dohmae N. The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association // J. Cell Sci. — The Company of Biologists, 2010. — ISSN 0021-9533; 1477-9137 — doi:10.1242/JCS.066266 — PMID:20605918
- ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
- ↑ 9,0 9,1 C Fratazzi, N Manjunath, Arbeit R. D. et al. A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43 // J. Exp. Med. — Rockefeller University Press, 2000. — ISSN 0022-1007; 1540-9538 — doi:10.1084/JEM.192.2.183 — PMID:10899905
- ↑ 10,0 10,1 10,2 Seveau S, Keller H, FR M. et al. Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule // Blood — American Society of Hematology, Elsevier BV, 2000. — ISSN 0006-4971; 1528-0020 — PMID:10753822
- ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
- ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
- Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
- Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)