VHL |
Нинди таксонда бар |
H. sapiens[d][1] |
Кодлаучы ген |
VHL[d][1] |
Молекуляр функция |
ubiquitin protein ligase activity[d][2], transcription factor binding[d][3][4], ubiquitin-protein transferase activity[d][5], связывание с белками плазмы[d][6][4][7][…], enzyme binding[d][4] һәм ubiquitin protein ligase activity[d][8][9] |
Күзәнәк компоненты |
цитоплазма[5], цитозоль[d][5][10], VCB complex[d][9], мембрана[d][5], нуклеоплазма[d][5][5], эндоплазматик челтәр[7], митохондрия[7], төш[11][12] һәм төш[10][5][9] |
Биологик процесс |
ДНК-зависимая регуляция транскрипции[d][13], protein stabilization[d][7], негативная регуляция апоптоза[d][7], negative regulation of transcription by RNA polymerase II[d][3], протеолиз[d][14], ДНК-зависимая позитивная регуляция транскрипции[d][15], positive regulation of cell differentiation[d][7], cell morphogenesis[d][7], regulation of transcription from RNA polymerase II promoter in response to hypoxia[d][5], negative regulation of transcription from RNA polymerase II promoter in response to hypoxia[d][4], негативная регуляция пролиферации клеток[d][16][17], negative regulation of gene expression[d][17], protein ubiquitination[d][12][18][12][…], посттрансляционная модификация[d][5], negative regulation of receptor signaling pathway via JAK-STAT[d][17], protein ubiquitination[d][18][12][2][…] һәм protein ubiquitination[d][5][7][5][…] |
|
VHL (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[19][20]
- ↑ 1,0 1,1 UniProt
- ↑ 2,0 2,1 Rousseaux M., Aleyasin H., Figeys D. et al. Regulation of the VHL/HIF-1 pathway by DJ-1 // J. Neurosci. / M. Picciotto — Society for Neuroscience, 2014. — ISSN 0270-6474; 1529-2401 — doi:10.1523/JNEUROSCI.1244-13.2014 — PMID:24899725
- ↑ 3,0 3,1 Duan D. R., A. Pause, Burgess W. H. et al. Inhibition of transcription elongation by the VHL tumor suppressor protein, Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein // Science / H. Thorp — Northern America: AAAS, 1995. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.7660122 — PMID:7660122
- ↑ 4,0 4,1 4,2 4,3 Semenza G. L. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity // Genes Dev. — Cold Spring Harbor Laboratory Press, 2001. — ISSN 0890-9369; 1549-5477 — doi:10.1101/GAD.924501 — PMID:11641274
- ↑ 5,00 5,01 5,02 5,03 5,04 5,05 5,06 5,07 5,08 5,09 5,10 GOA
- ↑ Li Z., Na X., Wang D. et al. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M108269200 — PMID:11739384
- ↑ 7,0 7,1 7,2 7,3 7,4 7,5 7,6 7,7 Cohen H. T. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M205040200 — PMID:12169691
- ↑ Rousseaux M., Aleyasin H., Figeys D. et al. Regulation of the VHL/HIF-1 pathway by DJ-1 // J. Neurosci. / M. Picciotto — Society for Neuroscience, 2014. — ISSN 0270-6474; 1529-2401 — doi:10.1523/JNEUROSCI.1244-13.2014 — PMID:24899725
- ↑ 9,0 9,1 9,2 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
- ↑ 10,0 10,1 Gnarra J. R. Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1995. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.92.14.6459 — PMID:7604013
- ↑ Gnarra J. R. Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1995. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.92.14.6459 — PMID:7604013
- ↑ 12,0 12,1 12,2 12,3 GOA
- ↑ Banks R. E., Johnson C. M., Maher E. R. Identification of novel VHL target genes and relationship to hypoxic response pathways // Oncogene — NPG, 2005. — ISSN 0950-9232; 1476-5594 — doi:10.1038/SJ.ONC.1208649 — PMID:15824735
- ↑ Ratcliffe P. J., Pugh C. W. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis // Nature / M. Skipper — NPG, Springer Science+Business Media, 1999. — ISSN 1476-4687; 0028-0836 — doi:10.1038/20459 — PMID:10353251
- ↑ Ivanov S. Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours // J. Pathol. — Wiley, 2008. — ISSN 0022-3417; 1096-9896 — doi:10.1002/PATH.2252 — PMID:17973242
- ↑ Kaelin W. G. Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C, Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C // Science / H. Thorp — Northern America: AAAS, 1995. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.7660130 — PMID:7660130
- ↑ 17,0 17,1 17,2 Kanno H., Sato H., Yokoyama T. et al. The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathway // Int. J. Oncol. / D. Spandidos — Spandidos Publishing, 2013. — ISSN 1019-6439; 1791-2423 — doi:10.3892/IJO.2013.1773 — PMID:23338840
- ↑ 18,0 18,1 Cohen H. T. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M205040200 — PMID:12169691
- ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
- ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
- Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
- Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)