DTX1

DTX1
Identifikatorlar
Nomenklatura	DTX1, hDx-1, deltex 1, deltex E3 ubiquitin ligase 1, RNF140
Tashqi IDlar	OMIM: 602582 MGI: 1352744 HomoloGene: 74522 GeneCards: DTX1
Gen joylashuvi (odam) Xr. Chromosome 12 (human)[1] Lokus 12q24.13 Bosh. 113,056,730 bp[1] Oxir. 113,098,028 bp[1]
Gen joylashuvi (sichqon) Xr. Chromosome 5 (mouse)[2] Lokus 5 F|5 60.64 cM Bosh. 120,818,267 bp[2] Oxir. 120,849,992 bp[2]
RNK ekspressiyasi profili Bgee Odam Sichqon (ortolog) Top expressed in Taloq right frontal lobe cingulate gyrus anterior cingulate cortex right hemisphere of cerebellum nucleus accumbens Brodmann area 9 Amigdala ganglionic eminence prefrontal cortex Top expressed in entorhinal cortex mesenteric lymph nodes perirhinal cortex dentate gyrus of hippocampal formation granule cell primary visual cortex Motor neyron superior colliculus cerebellar cortex lumbar subsegment of spinal cord Rostral migratory stream More reference expression data BioGPS More reference expression data
Gen ontologiyasi Molecular function SH3 domain binding transcription coactivator activity zinc ion binding protein binding ubiquitin protein ligase binding metal ion binding Notch binding transferase activity Cellular component Sitoplazma Hujayra yadrosi nucleoplasm cytosol nuclear body Biological process Notch signaling pathway cell surface receptor signaling pathway glial cell differentiation transcription by RNA polymerase II regulation of Notch signaling pathway negative regulation of T cell differentiation negative regulation of neuron differentiation protein ubiquitination transcription, DNA-templated cellular response to leukemia inhibitory factor positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Ortologiya Turlar Odam Sichqon Entrez 1840 14357 Ensembl ENSG00000135144 ENSMUSG00000029603 UniProt Q86Y01 Q61010 RefSeq (mRNK) NM_004416 NM_008052 RefSeq (protein) NP_004407 NP_032078 Location (UCSC) Chr 12: 113.06 – 113.1 Mb Chr 5: 120.82 – 120.85 Mb PubMed [3] [4]
Vikimaʼlumotlar
koʻrish/tahrirlash (odam) koʻrish/tahrirlash (sichqon)

Protein deltex-1 - bu odamlarda DTX1 geni tomonidan kodlangan oqsil^[5][6].

Xususiyati

Drosophilada olib borilgan tadqiqotlar, bu genni, tish signalizatsiya yoʻlining ijobiy regulyatorini kodlash sifatida aniqladi. Inson geni nomaʼlum funksiyali oqsilni kodlaydi. Lekin u asosiy spiral-loop-spiral transkripsiya omili faoliyatida rol oʻynashi mumkin^[6].

Oʻzaro taʼsirlari

DTX1 EP300 bilan oʻzaro aloqada boʻlishi koʻrsatilgan^[7].

Manbalar

1. GRCh38: Ensembl release 89: ENSG00000135144 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029603 - Ensembl, May 2017
3. „Human PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. „Mouse PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. „Human deltex is a conserved regulator of Notch signalling“. Nature Genetics. 19-jild, № 1. 1998-yil may. 74–8-bet. doi:10.1038/ng0598-74. PMID 9590294. {{cite magazine}}: sana kiritilishi kerak boʻlgan parametrga berilgan qiymatni tekshirish lozim: |date= (yordam)
6. „Entrez Gene: DTX1 deltex homolog 1 (Drosophila)“. Manba xatosi: Invalid <ref> tag; name "entrez" defined multiple times with different content
7. „Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor“. The Journal of Biological Chemistry. 276-jild, № 48. 2001-yil noyabr. 45031–40-bet. doi:10.1074/jbc.M105245200. PMID 11564735. {{cite magazine}}: sana kiritilishi kerak boʻlgan parametrga berilgan qiymatni tekshirish lozim: |date= (yordam)

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